Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Bridget Duvall"'
Autor:
Camilo Rojas, Reiji Tsukamoto, Daniel Bím, Tibor András Rokob, Takashi Tsukamoto, Zora Novakova, Gabriel Kabarriti, Cyril Barinka, Lubomír Rulíšek, Niyada Hin, Lucia Motlova, Dana Ferraris, Milos Budesinsky, Barbara S. Slusher, Bridget Duvall
Publikováno v:
Bioorganic & medicinal chemistry 27(2), 255-264 (2019). doi:10.1016/j.bmc.2018.11.022
Bioorganic & medicinal chemistry 27(2), 255 - 264 (2019). doi:10.1016/j.bmc.2018.11.022
A series of carbamate-based inhibitors of glutamate carboxypeptidase II (GCPII) were designed and synthesizedusing ZJ-43, N-[[[(1S)-1-carboxy-3-methylbutyl]a
A series of carbamate-based inhibitors of glutamate carboxypeptidase II (GCPII) were designed and synthesizedusing ZJ-43, N-[[[(1S)-1-carboxy-3-methylbutyl]a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d001bd0067a7fabf7a13427aebc7cb
https://doi.org/10.1016/j.bmc.2018.11.022
https://doi.org/10.1016/j.bmc.2018.11.022
Autor:
Rachel Shannon Helms, Chirag H. Patel, Robert D. Leone, Bridget Duvall, Run-Duo Gao, Takashi Tsukamoto, Barbara S. Slusher, Joel L. Pomerantz, Jonathan D Powell
Publikováno v:
The Journal of Immunology. 208:169.18-169.18
We sought to evaluate PAS domain containing kinase (PASK) inhibition during T cell differentiation using the previously described PASK inhibitor BioE-1197. Notably, CD8+, Th1, and Th2 T cells activated and expanded in the presence of BioE-1197 displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b71c1c7f93d6ce927c29a11af8432b8
https://doi.org/10.4049/jimmunol.208.supp.169.18
https://doi.org/10.4049/jimmunol.208.supp.169.18
Autor:
Rana Rais, Barbara S. Slusher, Vijayabhaskar Veeravalli, Anne Le, Run-Duo Gao, Bridget Duvall, Ajit G. Thomas, Amira Elgogary, Takashi Tsukamoto, Camilo Rojas, Sarah C. Zimmermann, Filip Kalčic
Publikováno v:
Bioorg Med Chem
A series of allosteric kidney-type glutaminase (GLS) inhibitors possessing a mercaptoethyl (-SCH(2)CH(2)-) linker were synthesized in an effort to further expand the structural diversity of chemotypes derived from bis-2-(5-phenylacetamido-1,3,4-thiad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25f973dcc7b5fdc64a0ba8e565b4d8e
https://doi.org/10.1016/j.bmc.2020.115698
https://doi.org/10.1016/j.bmc.2020.115698
Kidney-type glutaminase (GLS), the first enzyme in the glutaminolysis pathway, catalyzes the hydrolysis of glutamine to glutamate. GLS was found to be upregulated in many glutamine-dependent cancer cells. Therefore, selective inhibition of GLS has ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1500642d5af605f3c63d0024d2ad5bf4
https://europepmc.org/articles/PMC6335185/
https://europepmc.org/articles/PMC6335185/
Autor:
Edgar Schuck, Christopher Rowbottom, Camilo Rojas, Greg Delahanty, Barbara Slusher, Dana Ferraris, Bipin Mistry, Jesse Alt, Sanjeev Redkar, Bridget Duvall, Kristen Sanders, Takashi Tsukamoto, Kuan-Chun Huang
Publikováno v:
Journal of Medicinal Chemistry. 57:2582-2588
Several 2'-fluorinated tetrahydrouridine derivatives were synthesized as inhibitors of cytidine deaminase (CDA). (4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine (7a) showed enhanced acid stability over tetrahydrouridine (THU) 5 at its N-glycos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37774bf3f3512e3ee4b578687b2a33fe
https://doi.org/10.1021/jm401856k
https://doi.org/10.1021/jm401856k
Autor:
Dana Ferraris, Niyada Hin, Rana Rais, Barbara S. Slusher, Bridget Duvall, Takashi Tsukamoto, James F. Berry, Jesse Alt, Camilo Rojas
A series of 3-substituted 5-hydroxy-1,2,4-triazin-6(1H)-one derivatives were designed and synthesized as a new class of d-amino acid oxidase (DAAO) inhibitors. Some of the newly synthesized derivatives showed potent inhibitory activity against human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2e1e050caa25acef94243e83a64af2
https://europepmc.org/articles/PMC4816084/
https://europepmc.org/articles/PMC4816084/
Autor:
Jesse Alt, Bridget Duvall, Barbara S. Slusher, Dana Ferraris, Camilo Rojas, Niyada Hin, Kenji Hashimoto, Takashi Tsukamoto, Rana Rais, Ajit G. Thomas, James F. Berry
Publikováno v:
ACS Medicinal Chemistry Letters. 3:839-843
A series of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones were synthesized and evaluated for their ability to inhibit human and porcine forms of d-amino acid oxidase (DAAO). The inhibitory potency is largely dependent on the size and position of substitue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c75a618f91dea56cd237253b6224628
https://doi.org/10.1021/ml300212a
https://doi.org/10.1021/ml300212a
Autor:
Ying Wu, Krystyna M. Wozniak, Takashi Tsukamoto, Rana Rais, Dana Ferraris, Niyada Hin, Barbara S. Slusher, Camilo Rojas, Ajit G. Thomas, Jesse Alt, Bridget Duvall
Publikováno v:
Journal of Medicinal Chemistry
A series of 2-substituted 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives were synthesized as inhibitors of d-amino acid oxidase (DAAO). Many compounds in this series were found to be potent DAAO inhibitors, with IC50 values in the double-digit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f4348f54166e072d652f0005b9743d
https://pubmed.ncbi.nlm.nih.gov/26309148
https://pubmed.ncbi.nlm.nih.gov/26309148
Autor:
Bridget Duvall, William T. McElroy, Suzanne Bogacyzk, Krupa H. Shukla, Philip DeShong, Debra J. Boehmler, William A. Peterson
Publikováno v:
Organic Letters. 8:4183-4186
Palladium-catalyzed coupling of an aryl siloxane and an allylic carbonate proceeded in good yield to give an adduct that was converted to an analogue of (+/-)-7-deoxypancratistatin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032e6bda2ddca095e5b996f5f3465338
https://doi.org/10.1021/ol061070z
https://doi.org/10.1021/ol061070z
Autor:
Takashi Tsukamoto, Yao Sen Ko, Dana Ferraris, Camilo Rojas, Bridget Duvall, Kenji Hashimoto, Pavel Majer, Ajit G. Thomas
Publikováno v:
Journal of Medicinal Chemistry. 51:3357-3359
D-amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids including d-serine, a full agonist at the glycine site of the NMDA receptor. A series of benzo[ d]isoxazol-3-ol derivatives were synthesized and evaluated as DAAO inhibitors. Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3292f2d5df8d895e9f4a731c833f130e
https://doi.org/10.1021/jm800200u
https://doi.org/10.1021/jm800200u