Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bridget Carr"'
Autor:
Adele E. Connor, Claire Hughes, Lea Schäfer, Lorraine McNally, Deirdre O’ Raw, Katayoun Bahramian, Bridget Carr, Ingrid Halligan Dunne, Joanne Lysaght, Sharon A. O’ Toole, Jeremy C. Simpson, Antoinette S. Perry
Publikováno v:
Research Involvement and Engagement, Vol 9, Iss 1, Pp 1-6 (2023)
Abstract Public and Patient Involvement in research is becoming a requirement on most research funding applications; this includes both healthcare and lab-based research. Whilst case studies and practical guides have been developed and are well docum
Externí odkaz:
https://doaj.org/article/e41fb5ae0ff2409bb507e1ae1ff3a10c
Autor:
Anchi Cheng, Paul T. Kim, Huihui Kuang, Joshua H. Mendez, Eugene Y. D. Chua, Kashyap Maruthi, Hui Wei, Anjelique Sawh, Mahira F. Aragon, Viacheslav Serbynovskyi, Kasahun Neselu, Edward T. Eng, Clinton S. Potter, Bridget Carragher, Tristan Bepler, Alex J. Noble
Publikováno v:
IUCrJ, Vol 10, Iss 1, Pp 77-89 (2023)
Single-particle cryo-electron microscopy (cryoEM) is a swiftly growing method for understanding protein structure. With increasing demand for high-throughput, high-resolution cryoEM services comes greater demand for rapid and automated cryoEM grid an
Externí odkaz:
https://doaj.org/article/38ddd6438e3345ae9cf649c9abb5975b
Autor:
Kotaro Kelley, Ashleigh M. Raczkowski, Oleg Klykov, Pattana Jaroenlak, Daija Bobe, Mykhailo Kopylov, Edward T. Eng, Gira Bhabha, Clinton S. Potter, Bridget Carragher, Alex J. Noble
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Here the authors describe the Waffle Method, aimed at increasing the throughput of and solves several challenges present in cryo-FIB/SEM sample preparation for cryo-ET analysis — the highest-resolution method for obtaining 3D views of native biolog
Externí odkaz:
https://doaj.org/article/e079e893c227458c8f9d1347d6358ed8
Autor:
Wenguang G. Liang, Juwina Wijaya, Hui Wei, Alex J. Noble, Jordan M. Mancl, Swansea Mo, David Lee, John V. Lin King, Man Pan, Chang Liu, Carla M. Koehler, Minglei Zhao, Clinton S. Potter, Bridget Carragher, Sheng Li, Wei-Jen Tang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Presequence protease (PreP) is essential to mitochondrial proteostasis. This study leverages advanced vitrification techniques to solve cryoEM structures of apo- and substrate-bound PreP and integrates these data with other analysis to reveal key sta
Externí odkaz:
https://doaj.org/article/d99e3402e9504dfda0d7d987246a3e86
Publikováno v:
Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science. 2:7-16
New biosurety regulations and guidelines were implemented in 2003 because of increased concern for the safety and security of biological select agents and toxins (BSAT) that may be used as weapons of mass destruction. Biosurety is defined as the comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7165b7c3f58d91b9778fd917d26a39a
https://doi.org/10.1089/153871304322964291
https://doi.org/10.1089/153871304322964291
Autor:
Kasahun Neselu, Bing Wang, William J. Rice, Clinton S. Potter, Bridget Carragher, Eugene Y.D. Chua
Publikováno v:
Journal of Structural Biology: X, Vol 7, Iss , Pp 100085- (2023)
Ice thickness is a critical parameter in single particle cryo-EM – too thin ice can break during imaging or exclude the sample of interest, while ice that is too thick contributes to more inelastic scattering that precludes obtaining high resolutio
Externí odkaz:
https://doaj.org/article/216ec6425afd4e4499642356c3da4b60
Autor:
Oleg Klykov, Daija Bobe, Mohammadreza Paraan, Jake Johnston, Clinton Potter, Bridget Carragher, Mykhailo Kopylov, Alex Noble
Publikováno v:
Bio-Protocol, Vol 12, Iss 21 (2022)
Cryo-focused ion beam (FIB) milling of vitrified specimens is emerging as a powerful method for in situ specimen preparation. It allows for the preservation of native and near-native conditions in cells, and can reveal the molecular structure of prot
Externí odkaz:
https://doaj.org/article/82aefb10e3d8473a81eecfaa299accd1
Autor:
Yong Zi Tan, José Rodrigues, James E. Keener, Ruixiang Blake Zheng, Richard Brunton, Brian Kloss, Sabrina I. Giacometti, Ana L. Rosário, Lei Zhang, Michael Niederweis, Oliver B. Clarke, Todd L. Lowary, Michael T. Marty, Margarida Archer, Clinton S. Potter, Bridget Carragher, Filippo Mancia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase B EmbB involved in mycobacterial cell wall biosynthesis provides insights into the substrate binding and reaction mechanism. Mapping of the ethambutol resistance associated mutati
Externí odkaz:
https://doaj.org/article/eeb46691fab54cb4aea7d475e6b51125
Autor:
Jessica F. Bruhn, Giovanna Scapin, Anchi Cheng, Brandon Q. Mercado, David G. Waterman, Thejusvi Ganesh, Sargis Dallakyan, Brandon N. Read, Travis Nieusma, Kyle W. Lucier, Megan L. Mayer, Nicole J. Chiang, Nicole Poweleit, Philip T. McGilvray, Timothy S. Wilson, Michael Mashore, Camille Hennessy, Sean Thomson, Bo Wang, Clinton S. Potter, Bridget Carragher
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The emerging field of microcrystal electron diffraction (MicroED) is of great interest to industrial researchers working in the drug discovery and drug development space. The promise of being able to routinely solve high-resolution crystal structures
Externí odkaz:
https://doaj.org/article/4e8f74f2a00c436abdbb1fc0f9db7a2d
Autor:
Oliver J. Harrison, Julia Brasch, Phinikoula S. Katsamba, Goran Ahlsen, Alex J. Noble, Hanbin Dan, Rosemary V. Sampogna, Clinton S. Potter, Bridget Carragher, Barry Honig, Lawrence Shapiro
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2655-2671.e7 (2020)
Summary: Non-clustered δ1- and δ2-protocadherins, close relatives of clustered protocadherins, function in cell adhesion and motility and play essential roles in neural patterning. To understand the molecular interactions underlying these functions
Externí odkaz:
https://doaj.org/article/8f90b79156da49fcad93fd395bf1ec18