Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Bridget C. Lear"'
Autor:
Bart van Alphen, Samuel Stewart, Marta Iwanaszko, Fangke Xu, Keyin Li, Sydney Rozenfeld, Anujaianthi Ramakrishnan, Taichi Q. Itoh, Shiju Sisobhan, Zuoheng Qin, Bridget C. Lear, Ravi Allada
Publikováno v:
PLoS Biology, Vol 20, Iss 1 (2022)
In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo remain to be elucidated. To address this question, we developed a D
Externí odkaz:
https://doaj.org/article/16b98434805446f6932d8e47ce5e0777
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
The sodium leak channel NARROW ABDOMEN (NA)/ NALCN is an important component of circadian pacemaker neuronal output. In Drosophila, rhythmic expression of the NA channel regulator Nlf-1 in a subset of adult pacemaker neurons has been proposed to cont
Externí odkaz:
https://doaj.org/article/f456283e9fc045b7b679ba6715176c68
Publikováno v:
Sleep. 45(12)
Study Objectives To develop a new publicly available software SleepMat that analyzes Drosophila Activity Monitoring system data. Methods The software is built on Matlab platform, employs an easy-to-use graphic user interface, and is highly flexible t
The TIMELESS (TIM) phosphatase, Phosphatase of Regenerating Liver-1 (PRL-1), is required for setting behavioral phase especially under short photoperiod conditions. Yet the circadian clock neurons and underlying mechanisms important for these effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f9f6579bdff915a085200b2f8dc584f
https://doi.org/10.1101/2022.03.01.482487
https://doi.org/10.1101/2022.03.01.482487
Autor:
Casey O. Diekman, Tomas Andreani, Bridget C. Lear, William L. Kath, Ravi Allada, Jack Curran, Eric C. Johnson, Chunghun Lim, Tae Hee Han, Jongbin Lee, Matthew J. Moye
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance In animals, the control of daily sleep–wake rhythms is mediated by discrete circadian clock neurons via their rhythmic activity–dependent release of neuropeptides and neurotransmitters. Here, we describe a gene, Tango10, critical for
Publikováno v:
Hum Mol Genet
Disrupted circadian rhythms are a prominent feature of multiple neurodegenerative diseases. Yet mechanisms linking Tau to rhythmic behavior remain unclear. Here, we find that expression of a phosphomimetic human Tau mutant (TauE14) in Drosophila circ
Autor:
Hee Kyung Hong, Ima Samba, Michael Rosbash, Daniel C. Levine, Da Hyun Lee, Bridget C. Lear, Joseph Bass, Elzbieta Kula-Eversole, Ravi Allada, Evrim Yildirim
Publikováno v:
Curr Biol
The timing of behavior under natural light-dark conditions is a function of circadian clocks and photic input pathways. Yet a mechanistic understanding of how these pathways collaborate in animals is lacking. Here we demonstrate in Drosophila that th
Autor:
Michael A. Schon, Daniel F. Eberl, Kevin W. Christie, Madhuparna Roy, Bridget C. Lear, Benjamin T. Aldrich, Wesley C. Smith, Elena Sivan-Loukianova
Publikováno v:
Proceedings of the National Academy of Sciences. 110:15449-15454
Noise-induced hearing loss (NIHL) is a growing health issue, with costly treatment and lost quality of life. Here we establish Drosophila melanogaster as an inexpensive, flexible, and powerful genetic model system for NIHL. We exposed flies to acoust
Publikováno v:
Current Biology. 19(23):2050-2055
SummaryCircadian clocks in the brain are organized as coupled oscillators that integrate seasonal cues such as light and temperature to time daily behaviors. In Drosophila, the PIGMENT DISPERSING FACTOR (PDF) neuropeptide-expressing morning (M) and n
Autor:
Devon L. Moose, Kimberly Aranda, Elzbieta Kula-Eversole, Aaron R. Dinner, Bridget C. Lear, Tae Hee Han, Casey O. Diekman, Indira M. Raman, Ravi Allada, Kevin P. White, Matthieu Flourakis, Alan L. Hutchison, Dejian Ren
SummaryCircadian clocks regulate membrane excitability in master pacemaker neurons to control daily rhythms of sleep and wake. Here, we find that two distinctly timed electrical drives collaborate to impose rhythmicity on Drosophila clock neurons. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f59beeda7cb0976d9da82044254e436
https://europepmc.org/articles/PMC4537776/
https://europepmc.org/articles/PMC4537776/