Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bridget C. Boland"'
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 38:300-309
1-Nitronaphthalene (1-NN) and ozone are cytotoxic air pollutants commonly found as components of photochemical smog. The mechanism of toxicity for 1-NN involves bioactivation by cytochrome P450s and subsequent adduction to proteins. Previous studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bd5a769088ad285aa52974e94b1c93
https://doi.org/10.1165/rcmb.2005-0416oc
https://doi.org/10.1165/rcmb.2005-0416oc
Autor:
Dexter Morin, Teresa C. Wegesser, Alan R. Buckpitt, Bridget C. Boland, Åsa M. Wheelock, Charles G. Plopper, Margaret A. Isbell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 33:130-137
The incidence of serious photochemical smog events is steadily growing in urban environments around the world. The electrophilic metabolites of 1-nitronaphthalene (1-NN), a common air pollutant in urban areas, have been shown to bind covalently to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26fb20e9f55e0d0b3f78f33a0ed203d
https://doi.org/10.1165/rcmb.2005-0047oc
https://doi.org/10.1165/rcmb.2005-0047oc
Autor:
L. S. Van Winkle, Dexter Morin, R. Baldwin, Michelle V. Fanucchi, Michael A. Shultz, Bridget C. Boland, A. Karlsson, A. Taff, K. Chan, Jay A. A. West, Alan R. Buckpitt, Charles G. Plopper, Ching-Yu Lin, Margaret A. Isbell
Publikováno v:
Drug Metabolism Reviews. 34:791-820
The lung, which is in intimate contact with the external environment, is exposed to a number of toxicants both by virtue of its large surface area and because it receives 100% of the cardiac output. Lung diseases are a major disease entity in the U.S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbca19d90ea9ba3902e64ebe940dc28e
https://doi.org/10.1081/dmr-120015694
https://doi.org/10.1081/dmr-120015694
Autor:
Lisa A. Miller, Young Jin Lee, Bridget C. Boland, Michelle Salemi, Charles G. Plopper, Dexter Morin, Ching-Yu Lin, Alan R. Buckpitt
Publikováno v:
Proteomics. 6(3)
Naphthalene and 1-nitronaphthalene are ambient air pollutants, which undergo P450-dependent bioactivation in the lung. Reactive metabolites of naphthalene and 1-nitronaphthalene covalently bind to proteins, and the formation of covalent adducts corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e858611b4aa8b73ac7779e8b0dc645
https://pubmed.ncbi.nlm.nih.gov/16453347
https://pubmed.ncbi.nlm.nih.gov/16453347
Autor:
Alan R. Buckpitt, Jack M. Presley, Margaret A. Isbell, Bridget C. Boland, Dexter Morin, Michelle Salemi
Publikováno v:
Proteomics. 5(16)
Metabolic activation of inert chemicals to electrophilic intermediates has been correlated with the incidence and severity of cytotoxicity. The current studies have identified several proteins adducted by reactive metabolites of the lung toxicant, na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724d381e17a15e5bee65fb41aece57b1
https://pubmed.ncbi.nlm.nih.gov/16206326
https://pubmed.ncbi.nlm.nih.gov/16206326
Autor:
Charles G. Plopper, Margaret A. Isbell, Alison J. Weir, Gregory L. Baker, Michelle Salemi, Alan R. Buckpitt, William T. Jewell, Michelle V. Fanucchi, Ching-Yu Lin, Bridget C. Boland, Dexter Morin
Publikováno v:
Chemical research in toxicology. 18(5)
Airway epithelial cells are a susceptible site for injury by ambient air toxicants such as naphthalene that undergo P450-dependent metabolic activation. The metabolism of naphthalene in Clara cells to reactive intermediates that bind covalently to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cf2b72cf49001fc2ab26308fa1db80
https://pubmed.ncbi.nlm.nih.gov/15892573
https://pubmed.ncbi.nlm.nih.gov/15892573
Autor:
Charles G. Plopper, Dexter Morin, Lisa A. Miller, Alan R. Buckpitt, Ching-Yu Lin, Bridget C. Boland
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 310(2)
Studies in rodents have demonstrated the importance of cytochrome P450 monooxygenases in generating reactive metabolites that produce Clara cell injury. Pulmonary P450 activities in rodents are much higher than those in primates, raising the issue of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5a2b8f93e835312a79c2acf08ca6a0
https://pubmed.ncbi.nlm.nih.gov/15082753
https://pubmed.ncbi.nlm.nih.gov/15082753