Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Bridget, Gollan"'
Autor:
Julian A. Rycroft, Bridget Gollan, Grzegorz J. Grabe, Alexander Hall, Angela M. Cheverton, Gerald Larrouy-Maumus, Stephen A. Hare, Sophie Helaine
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The recalcitrance of many infections to antibiotic treatment may be due to the presence of ‘persisters’, or non-growing, antibiotic-tolerant bacteria. Here, the authors study the structures and functions of aminoacyl-tRNA acetyltransferase toxins
Externí odkaz:
https://doaj.org/article/3bed1ef83f1d4e429b13f75bbb4a9545
Autor:
Dmitry Bikmetov, Alexander M J Hall, Alexei Livenskyi, Bridget Gollan, Stepan Ovchinnikov, Konstantin Gilep, Jenny Y Kim, Gerald Larrouy-Maumus, Viktor Zgoda, Sergei Borukhov, Konstantin Severinov, Sophie Helaine, Svetlana Dubiley
Publikováno v:
Nucleic acids research. 50(10)
Type II toxin–antitoxin (TA) systems are two-gene modules widely distributed among prokaryotes. GNAT toxins associated with the DUF1778 antitoxins represent a large family of type II TAs. GNAT toxins inhibit cell growth by disrupting translation vi
Autor:
Elisabeth Kugelberg, Bridget Gollan, Christopher Farrance, Holly Bratcher, Jay Lucidarme, Ana Belén Ibarz-Pavón, Martin C J Maiden, Ray Borrow, Christoph M Tang
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9413 (2010)
Previously we have shown that insertion of IS1301 in the sia/ctr intergenic region (IGR) of serogroup C Neisseria meningitidis (MenC) isolates from Spain confers increased resistance against complement-mediated killing. Here we investigate the signif
Externí odkaz:
https://doaj.org/article/1f7f5ee99f814997860ffe9701bc8f52
Publikováno v:
Annual review of microbiology. 73
Persisters are nongrowing, transiently antibiotic-tolerant bacteria within a clonal population of otherwise susceptible cells. Their formation is triggered by environmental cues and involves the main bacterial stress response pathways that allow pers
Autor:
Petr V. Sergiev, Kira S. Makarova, Sophie Helaine, Bridget Gollan, Svetlana Dubiley, Brendan Wilcox, Yuri I. Wolf, Konstantin Severinov, Sergei Borukhov, Marina V. Serebryakova, Dmitry A. Lukyanov, Natalia Morozova, Ilya A. Osterman, Ekaterina S. Komarova
Publikováno v:
Nucleic Acids Research
Prokaryotic toxin–antitoxin (TA) modules are highly abundant and are involved in stress response and drug tolerance. The most common type II TA modules consist of two interacting proteins. The type II toxins are diverse enzymes targeting various es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2ef0bfc2d26e5bca276f0ee6ec911d
http://hdl.handle.net/10044/1/65546
http://hdl.handle.net/10044/1/65546
Many bacteria can infect and persist inside their hosts for long periods of time. In this Review, Fisher, Gollan and Helaine discuss recent developments in our understanding of bacterial persisters and their potential implications for the treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da7f972f2f87f0167d6f8e104893ae6
http://hdl.handle.net/10044/1/53563
http://hdl.handle.net/10044/1/53563
Autor:
Ray Borrow, Holly B. Bratcher, Bridget Gollan, Ana Belén Ibarz-Pavón, Jay Lucidarme, Christoph M. Tang, Elisabeth Kugelberg, Christopher Farrance, Martin C. J. Maiden
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9413 (2010)
PLoS ONE
PLoS ONE
Previously we have shown that insertion of IS1301 in the sia/ctr intergenic region (IGR) of serogroup C Neisseria meningitidis (MenC) isolates from Spain confers increased resistance against complement-mediated killing. Here we investigate the signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eef250a6c247e71b6eb256d0c2e365
https://ora.ox.ac.uk/objects/uuid:e13b0da8-2b46-416e-b734-94597da39bd5
https://ora.ox.ac.uk/objects/uuid:e13b0da8-2b46-416e-b734-94597da39bd5
Autor:
Angela M, Cheverton, Bridget, Gollan, Michal, Przydacz, Chi T, Wong, Anastasia, Mylona, Stephen A, Hare, Sophie, Helaine
Publikováno v:
Molecular cell. 63(1)
The recalcitrance of many bacterial infections to antibiotic treatment is thought to be due to the presence of persisters that are non-growing, antibiotic-insensitive cells. Eventually, persisters resume growth, accounting for relapses of infection.
Autor:
Elisabeth Kugelberg, Ronald Chalmers, Christoph M. Tang, Edmund Loh, Alexander Tracy, Helen A. Ewles, Bridget Gollan, Qian Zhang, Vladimir Pelicic
Publikováno v:
Nature
Nature, Nature Publishing Group, 2013, 502 (7470), pp.237-240. ⟨10.1038/nature12616⟩
Nature, Nature Publishing Group, 2013, 502 (7470), pp.237-240. ⟨10.1038/nature12616⟩
Neisseria meningitidis has several strategies to evade complement-mediated killing, and these contribute to its ability to cause septicaemic disease and meningitis. However, the meningococcus is primarily an obligate commensal of the human nasopharyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9ecc690e2f48db7e402bf0c64e1ac3
https://hal.archives-ouvertes.fr/hal-03514360
https://hal.archives-ouvertes.fr/hal-03514360
Autor:
Raquel Abad, Roland A. Fleck, Ray Borrow, Ian M. Feavers, Rachel M. Exley, Barbara Mulloy, Julio A. Vázquez, Bridget Gollan, Angel Chan, Hannah Chan, Christoph M. Tang, Qian Zhang, Andy Yarwood, Maria Jose Uria, Yanwen Li
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
The Journal of Experimental Medicine
Instituto de Salud Carlos III (ISCIII)
The Journal of Experimental Medicine
The presence of serum bactericidal antibodies is a proven correlate of protection against systemic infection with the important human pathogen Neisseria meningitidis. We have identified three serogroup C N. meningitidis (MenC) isolates recovered from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb86a35d79118780c47284899af7d7e8
https://hdl.handle.net/20.500.12105/7446
https://hdl.handle.net/20.500.12105/7446