Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bridge Hunter"'
Autor:
Richard Lieberman, Leslie K. Cortes, Grace Gao, Hyejung Park, Bing Wang, Patrick L. Jones, R. Bridge Hunter, John P. Leonard, Robert H. Barker
Publikováno v:
PLoS ONE, Vol 17, Iss 8 (2022)
Globoid cell leukodystrophy (Krabbe disease) is a fatal neurodegenerative, demyelinating disease caused by dysfunctional activity of galactosylceramidase (GALC), leading to the accumulation of glycosphingolipids including psychosine. While oligodendr
Externí odkaz:
https://doaj.org/article/00ddfe55df1b4645bbda90c529f4c8ba
Autor:
Kelly Keefe, Tanya Koellner, Michael R. Dufault, S. Pablo Sardi, Mindy Zhang, Robin J. Ziegler, Allyson Anding, Alexander Brezzani, Bridge Hunter, Kaitlyn Baranowski, Kelly George
Publikováno v:
Molecular Genetics and Metabolism. 132:S15
Autor:
Alison McVie-Wylie, Lindsay A. Quigley, Carol Dinardo, Kelly A. Keefe, Carol A. Nelson, Jennifer A. McCullough, Bruce M. Wentworth, Lorena Ceci, Nicholas P. Clayton, Stefan Girgenrath, John P. Leonard, Seng H. Cheng, William Weber, R. Bridge Hunter
Publikováno v:
The American Journal of Pathology. 178:2611-2621
Respiratory function is the main cause of mortality in patients with Duchenne muscular dystrophy (DMD). Elevated levels of TGF-β play a key role in the pathophysiology of DMD. To determine whether therapeutic attenuation of TGF-β signaling improves
Publikováno v:
American Journal of Physiology-Cell Physiology. 281:C1285-C1290
Disuse atrophy of skeletal muscle leads to an upregulation of genes encoding sarcoplasmic reticulum (SR) calcium-handling proteins. Because many of the proteins that are induced with endoplasmic reticulum (ER) stress are ER calcium-handling proteins,
Autor:
Steven J. Swoap, R. Bridge Hunter, Karyn A. Esser, Joshua M. Lang, Susan C. Kandarian, Eric J. Stevenson, Heather Mitchell Felton, Nilesh V. Kansagra
Publikováno v:
American Journal of Physiology-Cell Physiology. 279:C915-C924
To test for a role of the calcineurin-NFAT (nuclear factor of activated T cells) pathway in the regulation of fiber type-specific gene expression, slow and fast muscle-specific promoters were examined in C2C12 myotubes and in slow and fast muscle in
Publikováno v:
Journal of Biological Chemistry. 275:23005-23011
The skeletal muscle sarco(endo)plasmic reticulum calcium ATPase (SERCA1) gene is transactivated as early as 2 days after the removal of weight-bearing (Peters, D. G., Mitchell-Felton, H., and Kandarian, S. C. (1999) Am. J. Physiol. 276, C1218-C1225),
Autor:
Andrew R, Judge, Alan, Koncarevic, R Bridge, Hunter, Hsiou-Chi, Liou, Robert W, Jackman, Susan C, Kandarian
Publikováno v:
American journal of physiology. Cell physiology. 292(1)
Skeletal muscle atrophy is associated with a marked and sustained activation of nuclear factor-kappaB (NF-kappaB) activity. Previous work showed that p50 is one of the NF-kappaB family members required for this activation and for muscle atrophy. In t
Autor:
Heather Mitchell-Felton, Alan Koncarevic, R. Bridge Hunter, Susan C. Kandarian, David A. Essig, Eric J. Stevenson
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 16(6)
Although cytokine-induced nuclear factor kappaB (NF-kappaB) pathways are involved in muscle wasting subsequent to disease, their potential role in disuse muscle atrophy has not been characterized. Seven days of hind limb unloading led to a 10-fold ac
Publikováno v:
Europe PubMed Central
In the rat, denervation and hindlimb unloading are two commonly employed models used to study skeletal muscle atrophy. In these models, muscle atrophy is generally produced by a decrease in protein synthesis and an increase in protein degradation. Th
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