A computational approach for phenotypic comparisons of cell populations in high-dimensional cytometry data

Autor: Ludovic, Platon, David, Pejoski, Guillaume, Gautreau, Brice, Targat, Roger, Le Grand, Anne-Sophie, Beignon, Nicolas, Tchitchek

Publikováno v: Methods (San Diego, Calif.). 132

Cytometry is an experimental technique used to measure molecules expressed by cells at a single cell resolution. Recently, several technological improvements have made possible to increase greatly the number of cell markers that can be simultaneously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d734ce24065c7b00f7f4c9cc76b766ff
https://pubmed.ncbi.nlm.nih.gov/28917725

In vivo expansion of naive and activated CD4 + CD25 + FOXP3 + regulatory T cell populations in interleukin-2–treated HIV patients

Autor: Matthieu Carrière, Brice Targat, Arndt Benecke, Lars Rogge, Laurence Weiss, Sylvie Maiella, Vladimira Donkova-Petrini, Yves Levy, Fabrice A. Letimier

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2010, 107 (23), pp.10632-7. ⟨10.1073/pnas.1000027107⟩
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (23), pp.10632-7. ⟨10.1073/pnas.1000027107⟩

HIV-1 infection is characterized by a progressive decline in CD4 + T cells leading to a state of profound immunodeficiency. IL-2 therapy has been shown to improve CD4 + counts beyond that observed with antiretroviral therapy. Recent phase III trials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507ac73220beaf82fe43fddca402cb32
https://doi.org/10.1073/pnas.1000027107

CDS: A Fold-change Based Statistical Test for Concomitant Identification of Distinctness and Similarity in Gene Expression Analysis

Autor: Brice Targat, Nicolas Tchitchek, Jose Felipe Golib Dzib, Sebastian Noth, Annick Lesne, Arndt Benecke

Publikováno v: Genomics, Proteomics and Bioinformatics
Genomics, Proteomics and Bioinformatics, Elsevier, 2012, 10 (3), pp.127-135. ⟨10.1016/j.gpb.2012.06.002⟩
Genomics, Proteomics and Bioinformatics, 2012, 10 (3), pp.127-135. ⟨10.1016/j.gpb.2012.06.002⟩
Genomics, Proteomics & Bioinformatics

International audience; The problem of identifying differential activity such as in gene expression is a major defeat in biostatistics and bioinformatics. Equally important, however much less frequently studied, is the question of similar activity fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7466b7a8002ebe3539000ecebde2e3
https://hal.archives-ouvertes.fr/hal-01544156

TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53

Autor: Jimmy Vigneault-Edwards, Brice Targat, Mattia Frontini, Emmanuelle Wilhelm, Laszlo Tora, Brendan Bell, Mara Kornete, Arndt Benecke

Publikováno v: BMC Molecular Biology
BMC Molecular Biology, Vol 11, Iss 1, p 10 (2010)
BMC Molecular Biology, BioMed Central, 2010, 11 (1), pp.10. ⟨10.1186/1471-2199-11-10⟩
BMC Molecular Biology, 2010, 11 (1), pp.10. ⟨10.1186/1471-2199-11-10⟩

BackgroundTFIID is a multiprotein complex that plays a pivotal role in the regulation of RNA polymerase II (Pol II) transcription owing to its core promoter recognition and co-activator functions. TAF6 is a core TFIID subunit whose splice variants in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20aabfc5088d5d420680c87476091bf
https://pubmed.ncbi.nlm.nih.gov/20096117