Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Brice Le François"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15620 (2023)
Serotonin 1A (5-HT1A) autoreceptors located on serotonin neurons inhibit their activity, and their upregulation has been implicated in depression, suicide and resistance to antidepressant treatment. Conversely, post-synaptic 5-HT1A heteroreceptors ar
Externí odkaz:
https://doaj.org/article/f202ea3e1c1444ebac44bbbce9dfb772
Autor:
Tasha M. Santiago-Rodriguez, Brice Le François, Jean M. Macklaim, Evgueni Doukhanine, Emily B. Hollister
Publikováno v:
Microorganisms, Vol 11, Iss 5, p 1222 (2023)
Skin acts as a barrier that promotes the colonization of bacteria, fungi, archaea, and viruses whose membership and function may differ depending on the various specialized niches or micro-environments of the skin. The group of microorganisms inhabit
Externí odkaz:
https://doaj.org/article/eb89edfd7eb847e5aabeb8af9817cf22
Autor:
Brice Le François, Jeremy Soo, Anne M. Millar, Mireille Daigle, Anne-Marie Le Guisquet, Samuel Leman, Frédéric Minier, Catherine Belzung, Paul R. Albert
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 332-341 (2015)
The serotonin 1A receptor (5-HT1A), a critical regulator of the brain serotonergic tone, is implicated in major depressive disorder (MDD) where it is often found to be dys-regulated. However, the extent to which stress and antidepressant treatment im
Externí odkaz:
https://doaj.org/article/4ef41eeaf68e4bb7a2ca3f5391366701
Autor:
Paul R Albert, Brice Le François
Publikováno v:
Frontiers in Neuroscience, Vol 4 (2010)
Major depression is the most common form of mental illness, and is treated with antidepressant compounds that increase serotonin (5-HT) neurotransmission. Increased 5-HT1A autoreceptor levels in the raphe nuclei act as a “brake” to inhibit the 5-
Externí odkaz:
https://doaj.org/article/184cefa08e414599b687dd927c5d9df5
Publikováno v:
Journal of Psychiatry and Neuroscience. 44:164-176
Major depression and anxiety are highly prevalent and involve chronic dysregulation of serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic, epigenetic) and posttranscriptional (microRNA, alternative splicing)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408a2989bc113a022cc7fa608e6fa1d7
https://doi.org/10.1503/jpn.180209
https://doi.org/10.1503/jpn.180209
Autor:
Eitan Friedman, Gouri Mahajan, Lei Zhang, Brice Le François, Paul R. Albert, Craig A. Stockmeier
Publikováno v:
The Journal of Neuroscience. 38:8200-8210
The serotonin-1A (5-HT1A) receptor is a key regulator of serotonergic activity and is implicated in mood and emotion. However, its post-transcriptional regulation has never been studied in humans. In the present study, we show that the “intronless
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0d7f4a9e8d92fcffab482d91ab88df
https://doi.org/10.1523/jneurosci.0902-18.2018
https://doi.org/10.1523/jneurosci.0902-18.2018
Autor:
Jonathan S. James, Amin Zahrai, Brice Le François, René Hen, Zul Merali, Mireille Daigle, Zoe R. Donaldson, Valérie Turcotte-Cardin, Tristan J. Philippe, Paul R. Albert, Faranak Vahid-Ansari
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
The 5-HT1A autoreceptor mediates feedback inhibition of serotonin (5-HT) neurons, and is implicated in major depression. The human 5-HT1A gene (HTR1A) rs6295 risk allele prevents Deaf1 binding to HTR1A, resulting in increased 5-HT1A autoreceptor tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fbb066ed3f5218443498733522886d
http://europepmc.org/articles/PMC5893553
http://europepmc.org/articles/PMC5893553
Autor:
Alan R. Prescott, Sambit K. Nanda, Karine Enesa, Mark Peggie, Brice Le François, Paul R. Albert, Philip Cohen, Alban Ordureau
Publikováno v:
The Journal of Biological Chemistry
Background: The E3 ligase Pellino1 is required for interferon (IFN) β production following infection with Sendai virus or poly(I:C). Results: The transcription factor DEAF1 interacts with Pellino1 and, like Pellino1, is needed for transcription of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c42cba043cfa924b815c71757e068e0
http://europepmc.org/articles/PMC3750155
http://europepmc.org/articles/PMC3750155
Autor:
Faranak Vahid-Ansari, Mireille Daigle, Diane C. Lagace, Jean-Claude Béïque, Brice Le François, Tristan J. Philippe, Christine Luckhart, Sean D. Geddes, Paul R. Albert
Publikováno v:
Molecular Brain
The C (-1019) G rs6295 promoter polymorphism of the serotonin-1A (5-HT1A) receptor gene is associated with major depression in several but not all studies, suggesting that compensatory mechanisms mediate resilience. The rs6295 risk allele prevents bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac5d972a902bbee889123758b346e34
https://pubmed.ncbi.nlm.nih.gov/27488351
https://pubmed.ncbi.nlm.nih.gov/27488351
Autor:
Christopher Y, Chan, Inderbir, Singh, Heather, Magnuson, Mohammad, Zohaib, Kalindi P, Bakshi, Brice, Le François, Ana, Anazco-Ayala, Eung Jeon, Lee, Andrew, Tom, Kristel, YeeMon, Andre, Ragnauth, Eitan, Friedman, Shailesh P, Banerjee
Publikováno v:
Advances in experimental medicine and biology. 803
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6a71cd39ae77e9e623f0b99539b48fd
https://pubmed.ncbi.nlm.nih.gov/25833525
https://pubmed.ncbi.nlm.nih.gov/25833525