Evidence that the Amyloid-β Protein Precursor Intracellular Domain, AICD, Derives From β-Secretase-Generated C-Terminal Fragment

Autor: Raphaëlle Pardossi-Piquard, Jean Sevalle, Brice Flammang, Delphine Debayle, Frédéric Checler, Anne-Sophie Dabert-Gay, Inger Lauritzen, Aurelie Thevenet

Publikováno v: Journal of Alzheimer's Disease
Journal of Alzheimer's Disease, IOS Press, 2012, 30 (1), pp.145-53. ⟨10.3233/JAD-2012-112186⟩

International audience; One of the major pathological hallmarks of brains affected with Alzheimer's disease (AD) is the senile plaque, an extracellular deposit mainly composed of a set of highly insoluble peptides of various lengths (39-43 amino acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d167f29ad373ecf6a859a86baa46c67
https://doi.org/10.3233/jad-2012-112186