4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines

Autor: Pizzimenti S. 1, Briatore F. 1, Laurora S. 1, Toaldo C. 1, Maggio M. 1, De Grandi M. 1, Meaglia L. 1, Menegatti E. 2, Giglioni B. 3, Dianzani M.U. 1, Barrera G. 1

Publikováno v: Free radical biology & medicine 40 (2006): 1578–1591.
info:cnr-pdr/source/autori:Pizzimenti S. 1, Briatore F. 1, Laurora S. 1, Toaldo C. 1, Maggio M. 1, De Grandi M. 1, Meaglia L. 1, Menegatti E. 2, Giglioni B. 3, Dianzani M.U. 1, Barrera G. 1/titolo:4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines/doi:/rivista:Free radical biology & medicine/anno:2006/pagina_da:1578/pagina_a:1591/intervallo_pagine:1578–1591/volume:40

4-Hydroxynonenal (HNE), produced during oxidative stress, has an antiproliferative/differentiative effect in several tumor cells. Recently, it has been observed that oxidative stress accelerates telomere loss. The length of telomeres depends on the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::34289771d38e5c3381583e3fc9021365
http://www.cnr.it/prodotto/i/10242