Výsledky vyhledávání - "Brianne J. Ray"

Regulation of osteoclast structure and function by FAK family kinases

Autor: Cynthia Huang, Edward A. Botchwey, Michael F. Gutknecht, Amy H. Bouton, Keena S. Thomas, Brianne J. Ray

Publikováno v: Journal of Leukocyte Biology. 92:1021-1028

Regulation of distinct and overlapping functions of FAK family kinases in osteoclasts. Osteoclasts are highly specialized cells that resorb bone and contribute to bone remodeling. Diseases such as osteoporosis and osteolytic bone metastasis occur whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59b7ec81e54d601ad54a401d7392a41
https://doi.org/10.1189/jlb.0512259

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Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase

Autor: Alan F. Horwitz, Miguel Vicente-Manzanares, Brianne J. Ray, Fiona J. Pixley, J. Thomas Parsons, Amy H. Bouton, Katherine A. Owen, Keena S. Thomas, E. Richard Stanley, Hilary E. Beggs

Publikováno v: The Journal of Cell Biology

Macrophages are a key component of the innate immune system. In this study, we investigate how focal adhesion kinase (FAK) and the related kinase Pyk2 integrate adhesion signaling and growth factor receptor signaling to regulate diverse macrophage fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786c4af90cab2ab3f7c19b42471a6e43
http://europepmc.org/articles/PMC2140030

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Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density

Autor: Matthew J. Budoff, Yi-Hsiang Hsu, Thomas L. Clemens, Matthew A. Allison, Elizabeth C. Bryda, Eric Lum, Charles R. Farber, Michael H. Criqui, Larry D. Mesner, Ani Manichaikul, Clifford J. Rosen, Stephen S. Rich, Brianne J. Ray

Publikováno v: The Journal of clinical investigation, vol 124, iss 6

Patient bone mineral density (BMD) predicts the likelihood of osteoporotic fracture. While substantial progress has been made toward elucidating the genetic determinants of BMD, our understanding of the factors involved remains incomplete. Here, usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75e2b956c998214c71e2d8498047b25
https://pubmed.ncbi.nlm.nih.gov/24840320

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Abstract 3177: Cas overexpression in breast cancer confers resistance to chemotherapy by evading apoptosis and overcoming G0/G1 arrest

Autor: Amy H. Bouton, Huy Q. Ta, Brianne J. Ray

Publikováno v: Cancer Research. 70:3177-3177

Breast cancer patients treated with chemotherapy often develop resistance, resulting in highly aggressive tumors that are insensitive to drugs. Elucidating the mechanisms by which cancer cells are able to escape drug-induced apoptosis is thus paramou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2534683b9bc0068db6ddea255c0629e
https://doi.org/10.1158/1538-7445.am10-3177

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Abstract 1358: Focal adhesion kinase (FAK) regulates myeloid lineage cell activities that control murine tumor progression

Autor: Amy H. Bouton, Brianne J. Ray, Michael F. Gutknecht

Publikováno v: Cancer Research. 70:1358-1358

The tumor microenvironment is a critical regulator of tumor progression. Results from a broad spectrum of experimental models and analyses of human tumor specimens provide strong evidence that cells of the myeloid lineage have functional attributes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1feef63d6291f45d3d987525f028b670
https://doi.org/10.1158/1538-7445.am10-1358

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