Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Brianna Rivest"'
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Akademický článek
Self-delivering RNAi immunotherapeutic PH-762 silences PD-1 to generate local and abscopal antitumor efficacy
Autor: Benjamin Cuiffo, Melissa Maxwell, Dingxue Yan, Ramdane Guemiri, Andrew Boone, Deborah Bellet, Brianna Rivest, James Cardia, Caroline Robert, Simon P. Fricker
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
ObjectiveImmunotherapeutic inhibition of PD-1 by systemically administered monoclonal antibodies is widely used in cancer treatment, but it may cause severe immune-related adverse events (irSAEs). Neoadjuvant PD-1 inhibition before surgery has shown
Externí odkaz: https://doaj.org/article/4c11e064c3e94d87ae9030c00767206b
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Abstract 5113: INTASYL self-delivering RNAi therapeutic dual targeting PD-1 and CTLA-4 provides synergistic antitumor efficacy in the treatment of murine colon cancer in vivo
Autor: Benjamin G. Cuiffo, Andrew Boone, Dingxue Yan, Melissa Maxwell, Brianna Rivest, James Cardia, Simon P. Fricker
Publikováno v: Cancer Research. 83:5113-5113
Combination immune checkpoint inhibition (ICI) with antibodies targeting PD-1 and CTLA-4 provides superior outcomes compared to either monotherapy alone. This combination has been approved for advanced melanoma, metastatic colon cancer and others. Ho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e97289b243d09aa3f4bc9a3ffbb81520
https://doi.org/10.1158/1538-7445.am2023-5113
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Abstract 4237: Local administration of BRD4-targeting self-delivering RNAi (PH-894) provides abscopal efficacy toward untreated distal tumors and potentiates the efficacy of systemic anti-PD-1 antibody therapy
Autor: Benjamin Cuiffo, Melissa Maxwell, Dingxue Yan, Shenghua Zhou, Brianna Rivest, Andrew Boone, James Cardia, Simon P. Fricker
Publikováno v: Cancer Research. 82:4237-4237
Immune checkpoint inhibitor (ICI) anti-PD-1 antibody (mAb) monotherapy represented a significant advancement in cancer treatment, however most patients will ultimately progress, signaling the need for improvement. Combination approaches with other IC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01d853985e56a13e78e98bcc368ca7d6
https://doi.org/10.1158/1538-7445.am2022-4237
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869 Locally administered immunotherapy self-delivering RNAi PH-762 results in abscopal clearance of untreated distal tumors, suggesting systemic immune response, in a murine hepatocarcinoma model
Autor: Dingxue Yan, Benjamin G. Cuiffo, Melissa Maxwell, James Cardia, Brianna Rivest, Simon Fricker
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundThe development of locally administered immune checkpoint inhibition (ICI) holds potential promise for enhanced activity and decreased systemic toxicity, but such an approach is challenging with the available ICI antibodies. We have previou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9656e2547fc8b5cecbdbd9f1a3408206
https://doi.org/10.1136/jitc-2021-sitc2021.869
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