Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Brianna Powell"'
Autor:
Lei Wang, XueRong Lu, Alexandra Szalad, Xian Shuang Liu, Yi Zhang, Xinli Wang, William Anthony Golembieski, Brianna Powell, Mikkala Mccann, Mei Lu, Michael Chopp, Zheng Gang Zhang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
BackgroundMicroRNAs (miRNAs) in Schwann cells (SCs) mediate peripheral nerve function. Ablating Dicer, a key gene in miRNA biogenesis, in SCs causes peripheral neuropathy. Exosomes from healthy SCs (SC-Exo) ameliorate diabetic peripheral neuropathy i
Externí odkaz:
https://doaj.org/article/856755a479e6465db1eaaeb8d785bc39
Autor:
Huanjia Gao, Xianshuang Liu, Poornima Venkat, Elizabeth Findeis, Alex Zacharek, Brianna Powell, Mikkala Mccann, Harold Kim, Zhenggang Zhang, Michael Chopp
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
BackgroundVascular dementia (VaD) is a complex neurodegenerative disorder. We previously found that treatment of VaD in middle-aged male rats subjected to multiple microinfarction (MMI) with AV-001, a Tie2 receptor agonist, significantly improves cog
Externí odkaz:
https://doaj.org/article/05305eca27ba470fb9a6167fe4c51ff9
Autor:
Li Zhang, Hao Luo, Chao Li, Hua Teng, Brianna Powell, Mei Lu, Michael Chopp, Zheng Gang Zhang
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Stroke is a leading cause of death and disability worldwide, mainly affecting the elderly. Unfortunately, current treatments for acute ischemic stroke warrant improvement. To date, tissue plasminogen activator (tPA) is of limited use in stroke patien
Externí odkaz:
https://doaj.org/article/09117ecbeab445fea2396a9258c01359
Autor:
Huanjia Gao, Elizabeth L. Findeis, Lauren Culmone, Brianna Powell, Julie Landschoot-Ward, Alex Zacharek, Trueman Wu, Mei Lu, Michael Chopp, Poornima Venkat
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundVascular Dementia (VaD) refers to dementia caused by cerebrovascular disease and/or reduced blood flow to the brain and is the second most common form of dementia after Alzheimer’s disease. We previously found that in middle-aged rats sub
Externí odkaz:
https://doaj.org/article/4d240e67735245f18c3348a404bafd5b
Autor:
Poornima Venkat, Huanjia Gao, Elizabeth L. Findeis, Zhili Chen, Alex Zacharek, Julie Landschoot-Ward, Brianna Powell, Mei Lu, Zhongwu Liu, Zhenggang Zhang, Michael Chopp
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Background and purposeNon-alcoholic fatty liver disease (NAFLD) is known to adversely affect stroke recovery. However, few studies investigate how stroke elicits liver dysfunction, particularly, how stroke in type 2 diabetes mellitus (T2DM) exacerbat
Externí odkaz:
https://doaj.org/article/c1915052457249a395e9a0f8effb75d7
Autor:
Lauren Culmone, Brianna Powell, Julie Landschoot-Ward, Alex Zacharek, Huanjia Gao, Elizabeth L. Findeis, Ayesha Malik, Mei Lu, Michael Chopp, Poornima Venkat
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Background and PurposeVascular dementia (VaD) is a complex neurodegenerative disease affecting cognition and memory. There is a lack of approved pharmacological treatments specifically for VaD. In this study, we investigate the therapeutic effects of
Externí odkaz:
https://doaj.org/article/0dcae1863447444884ed69c8aad92abb
Autor:
Min Zhou, Rongwen Li, Poornima Venkat, Yu Qian, Michael Chopp, Alex Zacharek, Julie Landschoot-Ward, Brianna Powell, Quan Jiang, Xu Cui
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Patients with type 2 diabetes mellitus (T2DM) exhibit a distinct and high risk of ischemic stroke with worse post-stroke neurovascular and white matter (WM) prognosis than the non-diabetic population. In the central nervous system, the ATP-binding ca
Externí odkaz:
https://doaj.org/article/a7d6a848c9f144ef8307e7255e5525e8
Autor:
Li Zhang, Robin Schwartz-Byrne, Steven Gertz, Matthew McGuire, Colleen Woodhouse, Brianna Powell, Min Wei, Chao Li, Clare B. Billing, Todd A. Verdoorn, Leslie Lam, Tom J. Parry, Benjamin Buller, Zheng Gang Zhang, David Poulsen, Michael Chopp
Publikováno v:
Stroke. 53:3455-3464
Background: Ischemic stroke affects about 700 000 patients per year in the United States, and to date, there are no effective pharmacological agents that promote recovery. Here, we studied the pharmacokinetics, pharmacodynamics, and efficacy of NTS-1
Autor:
Alex Zacharek, Zhili Chen, Brianna Powell, Lauren Culmone, Julie Landschoot-Ward, Elizabeth Findeis, Huanjia Gao, Mei Lu, Michael Chopp, Zhongwu Liu, Poornima Venkat
Publikováno v:
Stroke. 54
Background: Cardiac complications post-stroke are common, and diabetes exacerbates post-stroke cardiac injury. In this study, we tested whether treatment with exosomes harvested from human umbilical cord blood derived CD133+ cells (CD133+Exo) improve
Autor:
Elyse M, Talley, Charlie T, Watts, Sonia, Aboyer, Madeline G, Adamson, Harriet Ab, Akoto, Haley, Altemus, Philip J, Avella, Rebecca, Bailey, Elizabeth R, Bell, Katheryn L, Bell, Kelsey, Breneman, Jessica S, Burkhart, Logan J, Chanley, Savannah S, Cook, Mackenzie T, DesLaurier, Timothy R, Dorsey, Cassandra J, Doyle, Merris E, Egloff, Ayoola S, Fasawe, Katy K, Garcia, Nathaniel P, Graves, Tyler K, Gray, Evan M, Gustafson, Makayla J, Hall, Jaden D, Hayes, Lindsay J, Holic, Brice A, Jarvis, Piotr S, Klos, Sidney, Kritzmire, Lera, Kuzovko, Edwyna, Lainez, Shamerra, McCoy, James C, Mierendorf, Nicole A, Neri, Caley R, Neville, Kelley, Osborn, Kaitlyn, Parker, Megan E, Parks, Kylee, Peck, Robyn, Pitt, Matthew E, Platta, Brianna, Powell, Katalina, Rodriguez, Clara, Ruiz, Mariah N, Schaefer, Amanda B, Shields, Jasmine B, Smiley, Briona, Stauffer, Devan, Straub, John L, Sweeney, Kaitlyn M, Termine, Brett, Thomas, Sophia D, Toth, Taylor R, Veile, Kayla S, Walker, Paige N, Webster, Brian J, Woodard, Quentin L, Yoder, McKenzie K, Young, McKenzie L, Zeedyk, Logan N, Ziegler, Kayla L, Bieser, David P, Puthoff, Joyce, Stamm, Alysia D, Vrailas-Mortimer, Jacob D, Kagey, Julie A, Merkle
Publikováno v:
microPublication Biology
Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in Drosophila melanogaster identified growth control phenotypes in the developing eye. One mutant line from this screen, H.3.2, was phenot