Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Brianna M Lax"'
Autor:
Emi A Lutz, K Dane Wittrup, Joseph R Palmeri, Brianna M Lax, Josh M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, William Pinney, Bryan D Bryson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/1d4f4929a5304e66974b9d6a359dc8a4
Autor:
Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman, K. Dane Wittrup
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Monoclonal antibodies targeting the programmed cell death protein 1 (PD-1) remain the most prevalent cancer immunotherapy both as a monotherapy and in combination with additional therapies. Despite the extensive success of anti-PD-1 monoclonal antibo
Externí odkaz:
https://doaj.org/article/a3566e931b5d476ea29616b10d00f10c
Autor:
Joseph R. Palmeri, Brianna M. Lax, Joshua M. Peters, Lauren Duhamel, Jordan A. Stinson, Luciano Santollani, Emi A. Lutz, William Pinney, Bryan D. Bryson, K. Dane Wittrup
Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves antitumor immune responses in preclinical studies, clinical development has been hampered by on-target, off-tumor toxicity. Here, we report the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c9a26a29bffbde5f9ff8ba4bf52371d
https://doi.org/10.1101/2023.01.30.526116
https://doi.org/10.1101/2023.01.30.526116
Autor:
Emi A. Lutz, Yash Agarwal, Noor Momin, Sarah C. Cowles, Joseph R. Palmeri, Ellen Duong, Vladlena Hornet, Allison Sheen, Brianna M. Lax, Adrienne M. Rothschilds, Darrell J. Irvine, Stefani Spranger, K. Dane Wittrup
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Effective antitumor immunity in mice requires activation of the type I interferon (IFN) response pathway. IFNα and IFNβ therapies have proven promising in humans, but suffer from limited efficacy and high toxicity. Intratumoral IFN retention amelio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7d4f5c144fec877bd5b917769ca413
https://doi.org/10.1073/pnas.2205983119
https://doi.org/10.1073/pnas.2205983119
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2491
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98a02291519bc7ff89c9e1c02beed4f9
https://pubmed.ncbi.nlm.nih.gov/35482183
https://pubmed.ncbi.nlm.nih.gov/35482183
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2491
Yeast surface display is a powerful directed evolution method for developing and engineering protein molecules to attain desired properties. Here, updated protocols are presented for purposes of identification of lead binders and their affinity matur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78415f16e83ee3584f88603e5e9dbf27
https://pubmed.ncbi.nlm.nih.gov/35713851
https://pubmed.ncbi.nlm.nih.gov/35713851
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afb2feb0870ceb4d61be44effd1cedaa
https://doi.org/10.1007/978-1-0716-2285-8_27
https://doi.org/10.1007/978-1-0716-2285-8_27
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bce02f2a0942223dd3db83555f8b33ec
https://doi.org/10.1007/978-1-0716-2285-8_2
https://doi.org/10.1007/978-1-0716-2285-8_2
Autor:
Joseph R. Palmeri, Brianna M. Lax, Joshua M. Peters, Lauren Duhamel, Jordan A. Stinson, Luciano Santollani, Emi A. Lutz, William Pinney, Bryan D. Bryson, K. Dane Wittrup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves antitumor immune responses in preclinical studies, clinical success has been limited by on-target, off-tumor activity. Here, we report the developmen
Externí odkaz:
https://doaj.org/article/8e65e3d9cba14ba3930a59f163a199fe