Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Briana Rackley"'
Autor:
Briana Rackley, Chang-Soo Seong, Evan Kiely, Rebecca E. Parker, Manali Rupji, Bhakti Dwivedi, John M. Heddleston, William Giang, Neil Anthony, Teng-Leong Chew, Melissa Gilbert-Ross
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Rackley, Seong et al use a Drosophila model of Ras/Lkb1 mutant carcinoma to show that high levels of the KRAS oncogene drive the malignant transformation of LKB1 mutant tissue. This pathway could be used as a target for future therapies that aim to t
Externí odkaz:
https://doaj.org/article/c4b905d7cae645a3acc0a94273ef360d
Autor:
Bhakti Dwivedi, Changsoo Seong, John M. Heddleston, Teng-Leong Chew, Briana Rackley, Rebecca E. Parker, Manali Rupji, Neil R. Anthony, William Giang, Melissa Gilbert-Ross, Evan Kiely
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology
The genetic and metabolic heterogeneity of RAS-driven cancers has confounded therapeutic strategies in the clinic. To address this, rapid and genetically tractable animal models are needed that recapitulate the heterogeneity of RAS-driven cancers in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2bf9ff3d4305ac546926ff5986f7ad0
https://doaj.org/article/c4b905d7cae645a3acc0a94273ef360d
https://doaj.org/article/c4b905d7cae645a3acc0a94273ef360d
Autor:
William Giang, John M. Heddleston, Bhakti Dwivedi, Neil R. Anthony, Changsoo Seong, Rebecca E. Parker, Teng-Leong Chew, Briana Rackley, Manali Rupji, Melissa Gilbert-Ross, Evan Kiely
The genetic and metabolic heterogeneity of RAS-driven cancers has confounded therapeutic strategies in the clinic. To address this, rapid and genetically tractable animal models are needed that recapitulate the heterogeneity of RAS-driven cancers in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88eb2d76ed67128a6830f37c099566cd
https://doi.org/10.1101/2020.09.25.308080
https://doi.org/10.1101/2020.09.25.308080
Publikováno v:
Molecular Cancer Research. 18:B04-B04
Although activating mutations in the GTPase KRAS are oncogenic and implicated in various malignancies, mutations in KRAS alone are inefficient to transform epithelia. In lung adenocarcinoma, KRAS mutations occur at high frequency and co-segregate wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cab0c4ab00e6dac7fc181b3fc699b24a
https://doi.org/10.1158/1557-3125.ras18-b04
https://doi.org/10.1158/1557-3125.ras18-b04