Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Briana C, Prager"'
Autor:
Olga Meiri Chaim, Shunichiro Miki, Briana C. Prager, Jianhui Ma, Anthony Y. Jeong, Jacqueline Lara, Nancy K. Tran, Jeffrey M. Smith, Jeremy N. Rich, J. Silvio Gutkind, Shigeki Miyamoto, Frank B. Furnari, Joan Heller Brown
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract In silico interrogation of glioblastoma (GBM) in The Cancer Genome Atlas (TCGA) revealed upregulation of GNA12 (Gα12), encoding the alpha subunit of the heterotrimeric G-protein G12, concomitant with overexpression of multiple G-protein cou
Externí odkaz:
https://doaj.org/article/e419c358a7d24206a72d5cdef498840f
Autor:
Lihui Liu, Ziyang Liu, Qinghua Liu, Wei Wu, Peng Lin, Xing Liu, Yuechuan Zhang, Dongpeng Wang, Briana C. Prager, Ryan C. Gimple, Jichuan Yu, Weixi Zhao, Qiulian Wu, Wei Zhang, Erzhong Wu, Xiaomin Chen, Jianjun Luo, Jeremy N. Rich, Qi Xie, Tao Jiang, Runsheng Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Glioblastoma (GBM) ranks among the most lethal of human cancers, containing glioma stem cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is highly expressed in GSCs compared to differentiated glioma cel
Externí odkaz:
https://doaj.org/article/89d5aa57675b4f25a388ae2c629d485a
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/df949ab109db40b48263658b608ddd9c
Autor:
Ryan C. Gimple, Guoxin Zhang, Shuai Wang, Tengfei Huang, Jina Lee, Suchet Taori, Deguan Lv, Deobrat Dixit, Matthew E. Halbert, Andrew R. Morton, Reilly L. Kidwell, Zhen Dong, Briana C. Prager, Leo J.Y. Kim, Zhixin Qiu, Linjie Zhao, Qi Xie, Qiulian Wu, Sameer Agnihotri, Jeremy N. Rich
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Glioblastoma is the most malignant primary brain tumor, the prognosis of which remains dismal even with aggressive surgical, medical, and radiation therapies. Glioblastoma stem cells (GSCs) promote therapeutic resistance and cellular heterogeneity du
Externí odkaz:
https://doaj.org/article/ec0fd42d418349639d81160bf89146e0
Autor:
Davide Bernareggi, Qi Xie, Briana C. Prager, Jiyoung Yun, Luisjesus S. Cruz, Timothy V. Pham, William Kim, Xiqing Lee, Michael Coffey, Cristina Zalfa, Pardis Azmoon, Huang Zhu, Pablo Tamayo, Jeremy N. Rich, Dan S. Kaufman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Genetic alteration can render tumor cells resistant to immune cell-mediated killing. Here based on a genome-wide CRISPR screening, the authors show that expression of CHMP2A confers tumor cell resistance to NK cell-mediated cytotoxicity, mechanistica
Externí odkaz:
https://doaj.org/article/c3382b59f84941a4b245398b952b3433
Autor:
Derrick Lee, Ryan C. Gimple, Xujia Wu, Briana C. Prager, Zhixin Qiu, Qiulian Wu, Vikas Daggubati, Aruljothi Mariappan, Jay Gopalakrishnan, Matthew R. Sarkisian, David R. Raleigh, Jeremy N. Rich
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Glioblastoma ranks among the most aggressive and lethal of all human cancers. Self-renewing, highly tumorigenic glioblastoma stem cells (GSCs) contribute to therapeutic resistance and maintain cellular heterogeneity. Here, we interrogated superenhanc
Externí odkaz:
https://doaj.org/article/9e622da572424f9dad2fb6932cf79adc
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
Adults with intellectual or developmental disability (IDD) comprise 1–2% of the population worldwide. IDD is a significant risk factor for premature morbidity or mortality. This is likely due in part to preventable health conditions, which are modi
Externí odkaz:
https://doaj.org/article/287edd85f1bc4ed8a0e11d60cab31106
Autor:
Li Jiang, Yajing Hao, Changwei Shao, Qiulian Wu, Briana C. Prager, Ryan C. Gimple, Gabriele Sulli, Leo J.Y. Kim, Guoxin Zhang, Zhixin Qiu, Zhe Zhu, Xiang-Dong Fu, Jeremy N. Rich
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor, containing GBM stem cells (GSCs) that contribute to therapeutic resistance and relapse. Exposing potential GSC vulnerabilities may provide therapeutic strategies against
Externí odkaz:
https://doaj.org/article/9e343997925d42dba86e8ff866779674
Autor:
Weiwei Tao, Aili Zhang, Kui Zhai, Zhi Huang, Haidong Huang, Wenchao Zhou, Qian Huang, Xiaoguang Fang, Briana C Prager, Xiuxing Wang, Qiulian Wu, Andrew E Sloan, Manmeet S Ahluwalia, Justin D Lathia, Jennifer S Yu, Jeremy N Rich, Shideng Bao
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 12, Pp n/a-n/a (2020)
Abstract Nuclear matrix‐associated proteins (NMPs) play critical roles in regulating chromatin organization and gene transcription by binding to the matrix attachment regions (MARs) of DNA. However, the functional significance of NMPs in glioblasto
Externí odkaz:
https://doaj.org/article/a5397199295d45629c5bcb2033be3620
Autor:
Abrar Choudhury, Stephen T. Magill, Charlotte D. Eaton, Briana C. Prager, William C. Chen, Martha A. Cady, Kyounghee Seo, Calixto-Hope G. Lucas, Tim J. Casey-Clyde, Harish N. Vasudevan, S. John Liu, Javier E. Villanueva-Meyer, Tai-Chung Lam, Jenny Kan-Suen Pu, Lai-Fung Li, Gilberto Ka-Kit Leung, Danielle L. Swaney, Michael Y. Zhang, Jason W. Chan, Zhixin Qiu, Michael V. Martin, Matthew S. Susko, Steve E. Braunstein, Nancy Ann Oberheim Bush, Jessica D. Schulte, Nicholas Butowski, Penny K. Sneed, Mitchel S. Berger, Nevan J. Krogan, Arie Perry, Joanna J. Phillips, David A. Solomon, Joseph F. Costello, Michael W. McDermott, Jeremy N. Rich, David R. Raleigh
Publikováno v:
Nature genetics, vol 54, iss 5
Nat Genet
Nat Genet
Meningiomas are the most common primary intracranial tumors. There are no effective medical therapies for meningioma patients, and new treatments have been encumbered by limited understanding of meningioma biology. Here, we use DNA methylation profil