Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Brian Y. Feng"'
Autor:
Jocelyn M. F. Ooi, Jessica M. Fairhall, Benjamin Spangler, Daniel J. W. Chong, Brian Y. Feng, Allan B. Gamble, Sarah Hook
Publikováno v:
RSC advances. 12(25)
Bioorthogonal chemistry can facilitate the development of fluorescent probes that can be used to sensitively and specifically detect the presence of biological targets. In this study, such an assay was developed to evaluate the uptake and delivery of
Autor:
Marc A. Coram, Lisha Wang, William J. Godinez, David T. Barkan, Zan Armstrong, D. Michael Ando, Brian Y. Feng
Publikováno v:
ACS infectious diseases. 8(1)
Combination therapies are common in many therapeutic contexts, including infectious diseases and cancer. A common approach for evaluating combinations
Publikováno v:
ACS Chemical Biology. 14:725-734
Compartmentalization is a crucial facet of many biological systems, and key aspects of cellular processes rely on spatial segregation within the cell. While many drug targets reside in specific intracellular compartments, the tools available for asse
Autor:
Colin K. Skepper, Robert J. Moreau, Brent A. Appleton, Bret M. Benton, Joseph E. Drumm, Brian Y. Feng, Mei Geng, Cheng Hu, Cindy Li, Andreas Lingel, Yipin Lu, Mulugeta Mamo, Wosenu Mergo, Mina Mostafavi, Christopher M. Rath, Micah Steffek, Kenneth T. Takeoka, Kyoko Uehara, Lisha Wang, Jun-Rong Wei, Lili Xie, Wenjian Xu, Qiong Zhang, Javier de Vicente
Publikováno v:
Journal of Medicinal Chemistry. 61:3325-3349
In the preceding manuscript [ Moreau et al. 2018 , 10.1021/acs.jmedchem.7b01691 ] we described a successful fragment-based lead discovery (FBLD) strategy for discovery of bacterial phosphopantetheine adenylyltransferase inhibitors (PPAT, CoaD). Follo
Autor:
Anke Blechschmidt, Brent A. Appleton, M. Geng, Jun-Rong Wei, J. de Vicente, Colin K. Skepper, Mika Lindvall, Bret Benton, Lili Xie, Brian Y. Feng, Carl J. Balibar, Qiong Zhang, Lisha Wang, Mulugeta Mamo, Valery Polyakov, Andreas Weiss, J.E. Drumm, Cindy Li, Wosenu Mergo, T.M. Smith, Kenneth T. Takeoka, Wenjian Xu, Kyoko Uehara, Yipin Lu, Robert J. Moreau, Andreas Lingel
Publikováno v:
Journal of Medicinal Chemistry. 61:3309-3324
The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a major challenge with fundamental importance to our global healthcare system. Part of our broad
Autor:
Srijan Ranjitkar, Xian Zhang, Robert Lowell Simmons, William J. Godinez, Imtiaz Hossain, Helen Chan, Brian Y. Feng, Cindy Li, Dita M. Rasper
Publikováno v:
ACS chemical biology. 14(6)
Beta-lactams comprise one of the earliest classes of antibiotic therapies. These molecules covalently inhibit enzymes from the family of penicillin-binding proteins (PBPs), which are essential in construction of the bacterial cell wall. As a result,
Autor:
Robert Lowell Simmons, Helen Chan, William J. Godinez, Dita M. Rasper, Imtiaz Hossain, Srijan Ranjitkar, Cindy Li, Brian Y. Feng, Xian Zhang
Beta-lactam antibiotics comprise one of the earliest known classes of antibiotic therapies. These molsecules covalently inhibit enzymes from the family of penicillin-binding proteins, which are essential to the construction of the bacterial cell wall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952e9b250d8acb775ccf88cd1be69e06
https://doi.org/10.1101/545335
https://doi.org/10.1101/545335
Autor:
Brian Y. Feng, Tsuyoshi Uehara, Ramadevi Prathapam, Mina Mostafavi, Pramila Tamrakar, Lisha Wang, Christopher M. Rath, William S. Sawyer, Louis E. Metzger
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 2, p e0211803 (2019)
PLoS ONE, Vol 14, Iss 2, p e0211803 (2019)
Lipopolysacharride (LPS) forms the outer leaflet of the outer membrane in Gram-negative bacteria and contributes to the permeability barrier and immune response. In this study, we established a method for monitoring the LPS biosynthetic intermediates
Autor:
Folkert Reck, Dustin Dovala, Katherine V. Thompson, David A. Six, William S. Sawyer, Benjamin Spangler, Brian Y. Feng
Publikováno v:
ACS infectious diseases. 4(9)
The Gram-negative cell envelope presents a formidable barrier to xenobiotics, and achieving sufficient compound exposure inside the cell is a key challenge for the discovery of new antibiotics. To provide insight on the molecular determinants governi
Autor:
Cindy Li, Mei Geng, Xiaoyu Shen, Joseph Drumm, Robert J. Moreau, Jun-Rong Wei, Colin K. Skepper, Bret Benton, Brian Y. Feng, Micah Steffek, Kenneth T. Takeoka, Lisha Wang, Christopher M. Rath, Wenjian Xu, Qiong Zhang, Javier de Vicente
Publikováno v:
ACS infectious diseases. 4(3)
Drug-resistant Gram-negative bacteria are of increasing concern worldwide. Novel antibiotics are needed, but their development is complicated by the requirement to simultaneously optimize molecules for target affinity and cellular potency, which can