Zobrazeno 1 - 10
of 2 787
pro vyhledávání: '"Brian Y"'
Autor:
Faris Gulamali, Pushkala Jayaraman, Ashwin S. Sawant, Jacob Desman, Benjamin Fox, Annette Chang, Brian Y. Soong, Naveen Arivazagan, Alexandra S. Reynolds, Son Q. Duong, Akhil Vaid, Patricia Kovatch, Robert Freeman, Ira S. Hofer, Ankit Sakhuja, Neha S. Dangayach, David S. Reich, Alexander W. Charney, Girish N. Nadkarni
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-7 (2024)
Abstract Increased intracranial pressure (ICP) ≥15 mmHg is associated with adverse neurological outcomes, but needs invasive intracranial monitoring. Using the publicly available MIMIC-III Waveform Database (2000–2013) from Boston, we developed a
Externí odkaz:
https://doaj.org/article/8d9fbb73568949159dfb9737079a6077
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract To facilitate inter-tissue communication and the exchange of proteins, lipoproteins, and metabolites with the circulation, hepatocytes have an intricate and efficient intracellular trafficking system regulated by small Rab GTPases. Here, we
Externí odkaz:
https://doaj.org/article/bd27f793846540b4abca69aca0dfe640
Autor:
Elena Zaikova, Brian Y. C. Cheng, Viviana Cerda, Esther Kong, Daniel Lai, Amy Lum, Cherie Bates, Wendie den Brok, Takako Kono, Sylvie Bourque, Angela Chan, Xioalan Feng, David Fenton, Anagha Gurjal, Nathalie Levasseur, Caroline Lohrisch, Sarah Roberts, Tamara Shenkier, Christine Simmons, Sara Taylor, Diego Villa, Ruth Miller, Rosalia Aguirre-Hernandez, Samuel Aparicio, Karen Gelmon
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Circulating tumour DNA (ctDNA) detection via liquid biopsy is an emerging alternative to tissue biopsy, but its potential in treatment response monitoring and prognosis in triple negative breast cancer (TNBC) is not yet well understood. Here
Externí odkaz:
https://doaj.org/article/8d2ce9df04da4b8887485568500718ae
Autor:
William Benman, Saachi Datta, David Gonzalez-Martinez, Gloria Lee, Juliette Hooper, Grace Qian, Gabrielle Leavitt, Lana Salloum, Gabrielle Ho, Sharvari Mhatre, Michael S. Magaraci, Michael Patterson, Sevile G. Mannickarottu, Saurabh Malani, Jose L. Avalos, Brian Y. Chow, Lukasz J. Bugaj
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The ability to perform sophisticated, high-throughput optogenetic experiments has been greatly enhanced by recent open-source illumination devices that allow independent programming of light patterns in single wells of microwell plates. Howe
Externí odkaz:
https://doaj.org/article/3efa70a4a8c0485dbec94aa00969e823
Publikováno v:
Journal of Cartilage & Joint Preservation, Vol 4, Iss 1, Pp 100147- (2024)
Introduction: Imaging of the articular cartilage of the extremities is a complex topic that is continually refined through advancements in imaging, surgery, and conservative management of chondral pathology. However, there are many commonly encounter
Externí odkaz:
https://doaj.org/article/84b806ccf4fa48549494157b4a982759
Autor:
Jose M. Ramos-Pittol, Isabel Fernandes-Freitas, Alexandra Milona, Stephen M. Manchishi, Kara Rainbow, Brian Y. H. Lam, John A. Tadross, Anthony Beucher, William H. Colledge, Inês Cebola, Kevin G. Murphy, Irene Miguel-Aliaga, Giles S. H. Yeo, Waljit S. Dhillo, Bryn M. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exe
Externí odkaz:
https://doaj.org/article/59195b68a82445d591a6b19294b35586
Autor:
Sherry-Ann Brown, Brian Y. Chung, Krishna Doshi, Abdulaziz Hamid, Erin Pederson, Ragasnehith Maddula, Allen Hanna, Indrajit Choudhuri, Rodney Sparapani, Mehri Bagheri Mohamadi Pour, Jun Zhang, Anai N. Kothari, Patrick Collier, Pedro Caraballo, Peter Noseworthy, Adelaide Arruda-Olson, for the Cardio-Oncology Artificial Intelligence Informatics and Precision Equity (CAIPE) Research Team Investigators
Publikováno v:
Cardio-Oncology, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Background The many improvements in cancer therapies have led to an increased number of survivors, which comes with a greater risk of consequent/subsequent cardiovascular disease. Identifying effective management strategies that can mitigate
Externí odkaz:
https://doaj.org/article/b26d5d15ae0c4ce999952205f414e93b
Autor:
Geoffrey B. Severin, Miriam S. Ramliden, Kathryne C. Ford, Andrew J. Van Alst, Ram Sanath-Kumar, Kaitlin A. Decker, Brian Y. Hsueh, Gong Chen, Soo Hun Yoon, Lucas M. Demey, Brendan J. O'Hara, Christopher R. Rhoades, Victor J. DiRita, Wai-Leung Ng, Christopher M. Waters
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT A major challenge faced by bacteria is infection by bacteriophage (phage). Abortive infection is one strategy for combating phage in which an infected cell kills itself to limit phage replication, thus protecting neighboring kin. One class o
Externí odkaz:
https://doaj.org/article/0aeb68be07a940b3b442d2253ef708df
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011195 (2023)
Toxin-antitoxin (TA) systems are ubiquitous two-gene loci that bacteria use to regulate cellular processes such as phage defense. Here, we demonstrate the mechanism by which a novel type III TA system, avcID, is activated and confers resistance to ph
Externí odkaz:
https://doaj.org/article/789b1f49a9b24a958db44b08655778ff
Autor:
John Hilton, Karen Gelmon, Philippe L. Bedard, Dongsheng Tu, Hong Xu, Anna V. Tinker, Rachel Goodwin, Scott A. Laurie, Derek Jonker, Aaron R. Hansen, Zachary W. Veitch, Daniel J. Renouf, Linda Hagerman, Hongbo Lui, Bingshu Chen, Deb Kellar, Irene Li, Sung-Eun Lee, Takako Kono, Brian Y. C. Cheng, Damian Yap, Daniel Lai, Sean Beatty, John Soong, Kathleen I. Pritchard, Isabel Soria-Bretones, Eric Chen, Harriet Feilotter, Moira Rushton, Lesley Seymour, Samuel Aparicio, David W. Cescon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
G-quadruplex stabilizers, including CX-5461, exhibit synthetic lethality with loss of BRCA1/2 in preclinical models. Here the authors report the results of a phase I study of CX-5461 in patients with solid tumors enriched for DNA-repair deficiencies.
Externí odkaz:
https://doaj.org/article/ee095627571b4e258e1890f77d3d7597