Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Brian Wolpin"'
Autor:
Sandor Spisak, David Chen, Pornlada Likasitwatanakul, Paul Doan, Zhixin Li, Pratyusha Bala, Laura Vizkeleti, Viktoria Tisza, Pushpamali De Silva, Marios Giannakis, Brian Wolpin, Jun Qi, Nilay S. Sethi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Aberrant stem cell-like activity and impaired differentiation are central to the development of colorectal cancer (CRC). To identify functional mediators of these key cellular programs, we engineer a dual endogenous reporter system by genome
Externí odkaz:
https://doaj.org/article/64f740c5a2e84b8d8be33accd3e0a80f
Autor:
Tanios Bekaii-Saab, Todd Bauer, Gina Petroni, Osama Rahma, Rawad Elias, Craig Slingluff, Mathew Katz, Brian Wolpin, Chee-Chee Stucky, Andressa Dias-Costa, Jonathan Nowak, Lenehan Patrick, Stephanie Dougan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/1e492dfb3b3045b28b3e5a504b4ff11e
Autor:
Matthew H. G. Katz, Fang-Shu Ou, Joseph M. Herman, Syed A. Ahmad, Brian Wolpin, Robert Marsh, Spencer Behr, Qian Shi, Michael Chuong, Lawrence H. Schwartz, Wendy Frankel, Eric Collisson, Eugene J. Koay, JoLeen M. Hubbard, James L. Leenstra, Jeffrey Meyerhardt, Eileen O’Reilly, for the Alliance for Clinical Trials on Oncology
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017)
Abstract Background Borderline resectable pancreatic cancers infiltrate into adjacent vascular structures to an extent that makes an R0 resection unlikely when pancreatectomy is performed de novo. In a pilot study, Alliance for Clinical Trials in Onc
Externí odkaz:
https://doaj.org/article/309dcfbae6bc4c4bbb5d12861352a1a3
Autor:
Peter Kraft, Alkes L. Price, Benjamin Neale, David J. Hunter, Christopher A. Haiman, Douglas Easton, Rosalind Eeles, Sonja Berndt, Andrew Chan, Jenny Chang-Claude, Jeroen R. Huyghe, Li Hsu, Brian Wolpin, Harvey Risch, Gloria Petersen, Alison Klein, Rachael Stolzenberg-Solomon, Laufey T. Amundadottir, Thomas A. Sellers, Ellen L. Goode, Hui-Yi Lin, Jennifer B. Permuth, David Conti, Stephen B. Gruber, Kristin Rand, Rayjean J. Hung, Christopher I. Amos, Fredrick R. Schumacher, Brendan Bulik-Sullivan, Hilary Finucane, Sara Lindström
Supplementary Table S1: Non-cancer diseases and traits included in the analysis and source of summary statistics Supplementary Table S2. Cancer-specific cumulative risks from SEER. Supplementary Table S3: Genetic correlations between cancers and 14 n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f30d535ae715a3947f886ae20ea86e
https://doi.org/10.1158/1055-9965.22436439.v1
https://doi.org/10.1158/1055-9965.22436439.v1
Autor:
Peter Kraft, Alkes L. Price, Benjamin Neale, David J. Hunter, Christopher A. Haiman, Douglas Easton, Rosalind Eeles, Sonja Berndt, Andrew Chan, Jenny Chang-Claude, Jeroen R. Huyghe, Li Hsu, Brian Wolpin, Harvey Risch, Gloria Petersen, Alison Klein, Rachael Stolzenberg-Solomon, Laufey T. Amundadottir, Thomas A. Sellers, Ellen L. Goode, Hui-Yi Lin, Jennifer B. Permuth, David Conti, Stephen B. Gruber, Kristin Rand, Rayjean J. Hung, Christopher I. Amos, Fredrick R. Schumacher, Brendan Bulik-Sullivan, Hilary Finucane, Sara Lindström
Background: Many cancers share specific genetic risk factors, including both rare high-penetrance mutations and common SNPs identified through genome-wide association studies (GWAS). However, little is known about the overall shared heritability acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4c8a899e8be2d11d7fbe71b0cf2be2
https://doi.org/10.1158/1055-9965.c.6515397.v1
https://doi.org/10.1158/1055-9965.c.6515397.v1
Autor:
Jimmy A. Guo, Jennifer Su, Carina Shiau, Ananya Jambhale, Annan Yang, Westley Wu, Junning Wang, Connor Hennessey, Patrick Yu, Brendan Parent, Giselle Uribe, Julien Dilly, Laleh Abbassi, Qijia Yu, Arnav Mehta, David Ting, Brian Wolpin, William Freed-Pastor, Joseph Mancias, Tyler Jacks, William L. Hwang, Andrew J. Aguirre
Publikováno v:
Cancer Research. 83:5775-5775
Pancreatic cancer is a challenging disease which lacks a robust precision oncology framework. Prior work has demonstrated that transcriptional subtypes in pancreatic cancer can stratify patients by response to chemotherapy and overall survival. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4d6029238aabeda3bd7aa388423b8cc
https://doi.org/10.1158/1538-7445.am2023-5775
https://doi.org/10.1158/1538-7445.am2023-5775
Autor:
Kerry L. Ivey, Eric B. Rimm, Peter Kraft, Clary B. Clish, Aedin Cassidy, Jonathan Hodgson, Kevin Croft, Brian Wolpin, Liming Liang
Publikováno v:
Journal of Nutritional Science, Vol 6 (2017)
High flavonoid consumption can improve vascular health. Exploring flavonoid–metabolome relationships in population-based settings is challenging, as: (i) there are numerous confounders of the flavonoid–metabolome relationship; and (ii) the set of
Externí odkaz:
https://doaj.org/article/a6fd6e4d739d41bcb6734175c261746a
Publikováno v:
Gastroenterology. 163(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c44941f3fde4f04c6377caea3f04a0a
https://pubmed.ncbi.nlm.nih.gov/35788343
https://pubmed.ncbi.nlm.nih.gov/35788343
Autor:
Jianxin Shi, Ju-Hyun Park, Jubao Duan, Sonja T Berndt, Winton Moy, Kai Yu, Lei Song, William Wheeler, Xing Hua, Debra Silverman, Montserrat Garcia-Closas, Chao Agnes Hsiung, Jonine D Figueroa, Victoria K Cortessis, Núria Malats, Margaret R Karagas, Paolo Vineis, I-Shou Chang, Dongxin Lin, Baosen Zhou, Adeline Seow, Keitaro Matsuo, Yun-Chul Hong, Neil E Caporaso, Brian Wolpin, Eric Jacobs, Gloria M Petersen, Alison P Klein, Donghui Li, Harvey Risch, Alan R Sanders, Li Hsu, Robert E Schoen, Hermann Brenner, MGS (Molecular Genetics of Schizophrenia) GWAS Consortium, GECCO (The Genetics and Epidemiology of Colorectal Cancer Consortium), GAME-ON/TRICL (Transdisciplinary Research in Cancer of the Lung) GWAS Consortium, PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations) Consortium, PanScan Consortium, GAME-ON/ELLIPSE Consortium, Rachael Stolzenberg-Solomon, Pablo Gejman, Qing Lan, Nathaniel Rothman, Laufey T Amundadottir, Maria Teresa Landi, Douglas F Levinson, Stephen J Chanock, Nilanjan Chatterjee
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006493 (2016)
Recent heritability analyses have indicated that genome-wide association studies (GWAS) have the potential to improve genetic risk prediction for complex diseases based on polygenic risk score (PRS), a simple modelling technique that can be implement
Externí odkaz:
https://doaj.org/article/a59b3243ed1d40f794cbb7048b649f62
Autor:
Paul E. Oberstein, Osama Rahma, Nina Beri, Amy Stoll-D'Astice, Emily A. Kawaler, Igor Dolgalev, Gregor Werba, Victoire Cardo-Ruffino, Naïma Böllenrücher, Andressa Dias Costa, Saloney Nazeer, Matthew Squires, Jonathan Nowak, Dafna Bar-Sagi, Brian Wolpin, Diane M Simeone, Stephanie K Dougan
Publikováno v:
Cancer Research. 82:PR005-PR005
In preclinical work, the inflammatory cytokine IL-1β was shown to be upregulated in pancreatic cancer tumors and to contribute to activation of pancreatic stellate cells and immunosuppression (Das et al 2020). We conducted an open-label multicenter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58104e99d888c89fd24562dc3b984d47
https://doi.org/10.1158/1538-7445.panca22-pr005
https://doi.org/10.1158/1538-7445.panca22-pr005