Výsledky vyhledávání - "Brian Winther"

Evaluation of Serum Carnitine Levels for Pediatric Patients Receiving Carnitine-Free and Carnitine-Supplemented Parenteral Nutrition

Autor: Cecilia W. Mulroy, Brian Winther, Daniel Jackson, Mark MacKay

Purpose Carnitine is a carrier molecule transporting long-chain fatty acids (LCFAs) into the mitochondria for fatty acid β-oxidation. The purpose of this study is to evaluate the role of carnitine supplementation in parenteral nutrition (PN) within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe55ed8f03e9f79c70dc784c6ccfe68
https://europepmc.org/articles/PMC4062735/

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High-Efficiency Retrovirus-Mediated Gene Transfer into the Livers of Mice

Autor: Leonard Meuse, André Lieber, Gijsbert A. Patijn, Brian Winther, Mark A. Kay

Publikováno v: Human Gene Therapy. 9:1449-1456

Recombinant retroviral vectors represent an attractive means of transferring genes into the liver because they integrate in the host cell genome and result in permanent gene expression. However, efficient gene transfer is limited by the requirement o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830680f8d496aa495348f846183ef2ab
https://doi.org/10.1089/hum.1998.9.10-1449

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Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

Autor: Leonard Meuse, Allen M. Gown, D Nagy, L. K. Cohen, Richard O. Snyder, Olivier Danos, Arthur R. Thompson, Carol H. Miao, Mark A. Kay, Brian Winther, Gijsbert A. Patijn, S. K. Spratt

Publikováno v: Nature Genetics. 16:270-276

Haemophilia B, or factor IX deficiency, is a X-linked recessive disorder that occurs in about one in 25,000 males, and severely affected people are at risk for spontaneous bleeding into numerous organs. Bleeding can be life-threatening or lead to chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec3c141f54da4f210bcce5fe528a42b
https://doi.org/10.1038/ng0797-270

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Physical and chemical stability of iron sucrose in parenteral nutrition

Autor: Gwendolyn A. McMillin, William Rusho, Brian Winther, Mark MacKay, Daniel Jackson

Publikováno v: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 24(6)

Current literature supports iron dextran as the only iron preparation compatible with parenteral nutrition (PN). Iron sucrose has been used for iron replacement therapy because of its lower rate of adverse events. The purpose of this study is to dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a75a19b462e98e1a7211399ae115ff1
https://pubmed.ncbi.nlm.nih.gov/19955552

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The kinetics of rAAV integration in the liver

Autor: Brian A. Donahue, David B. Schowalter, Richard O. Snyder, Gijsbert A. Patijn, Carol H. Miao, Mark A. Kay, Brian Winther

Publikováno v: Nature Genetics. 19:13-15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadc562c42c4123ea4a06e85adae3f0e
https://doi.org/10.1038/ng0598-13

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Implication of interfering antibody formation and apoptosis as two different mechanisms leading to variable duration of adenovirus-mediated transgene expression in immune-competent mice

Autor: Mark A. Kay, Christopher B. Wilson, Brian Winther, David B. Schowalter, Charis L. Himeda

Publikováno v: Journal of virology. 73(6)

This study explores the genetic and immunologic factors involved in the differences in duration of transgene expression following in vivo transduction with recombinant adenoviruses. Different strains of mice (C3H/HeJ [C3H], C57BL/6J [B6], BALB/cJ [Ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981cc6cb496a735032dc0cb47c10b402
https://pubmed.ncbi.nlm.nih.gov/10233936

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The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors

Autor: André Lieber, Leonard Meuse, Cheng Yi He, Irina Kirillova, David B. Schowalter, Mark A. Kay, Brian Winther

Publikováno v: Journal of virology. 71(11)

Systemic application of first-generation adenovirus induces pathogenic effects in the liver. To begin unraveling the mechanisms underlying early liver toxicity after adenovirus infusion, particularly the role of macrophage activation and expression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ebaebbbabc2565beb5ba8892e0b60f
https://pubmed.ncbi.nlm.nih.gov/9343240

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Pseudotransduction of hepatocytes by using concentrated pseudotyped vesicular stomatitis virus G glycoprotein (VSV-G)-Moloney murine leukemia virus-derived retrovirus vectors: comparison of VSV-G and amphotropic vectors for hepatic gene transfer

Autor: Miao-Liang Liu, Brian Winther, Mark A. Kay

Publikováno v: Journal of virology. 70(4)

Recombinant retrovirus vectors are widely used for gene transfer studies. The recent development of a pseudotyped Moloney murine leukemia virus vector that contains the G envelope protein from the vesicular stomatitis virus allows for efficient conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9ba0c7f8b85dcd3718c42b52f44bc5
https://pubmed.ncbi.nlm.nih.gov/8642678

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