Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Brian Whiting"'
Publikováno v:
Pharmaceutical Research. 12:729-737
Monte Carlo simulation technique used to evaluate the effect of the arrangement of concentrations on the efficiency of estimation of population pharmacokinetic parameters in the preclinical setting is described. Although the simulations were restrict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a79a082cba3f66e0bb4be8001e30eae
https://doi.org/10.1023/a:1016267811074
https://doi.org/10.1023/a:1016267811074
Autor:
Brian Whiting, Susan Wallace
Publikováno v:
British journal of clinical pharmacology. 1(4)
1 The binding of [(3)H]-digoxin to human plasma proteins was studied using both ultrafiltration and frontal analysis, to establish a suitable method for the measurement of digoxin-protein interaction, and to assess the effect of variations in digoxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e2f02798f5124b5add40213b7ef67b
https://pubmed.ncbi.nlm.nih.gov/22454887
https://pubmed.ncbi.nlm.nih.gov/22454887
Publikováno v:
Clinical Research and Regulatory Affairs. 11:121-139
Single response population (1 sample / animal) simulation studies were carried out (assuming a 1 compartment model) to investigate the influence of inter-animal variability (in clearance (σCl) and volume (σv)) on the estimation of population pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9f7d767aa4f73a6d7fa91b6d8879da
https://doi.org/10.3109/10601339409005295
https://doi.org/10.3109/10601339409005295
Autor:
Roger Williams, Tredger Jm, Brian Whiting, A. A. Niven, J. Grevel, C M Steward, Nikolai V. Naoumov
Publikováno v:
European Journal of Clinical Pharmacology. 40:513-519
Pharmacokinetic variables were derived from cyclosporine measurements using liquid chromatography (HPLC) and radioimmunoassay with a non-selective polyclonal antibody (PARIA) in 11 orthotopic liver transplant recipients studied in paired oral and int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f737a69885787a50f9a4d4a6f4b591
https://doi.org/10.1007/bf00315232
https://doi.org/10.1007/bf00315232
Publikováno v:
Journal of travel medicine. 7(6)
Background An integral part of the training for many UK medical undergraduates involves a period of elective study abroad. There is concern about the health risks this poses to the students, and uncertainty regarding the responsibility this places on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818776e1056023a16133b9c3e81ee033
https://pubmed.ncbi.nlm.nih.gov/11305241
https://pubmed.ncbi.nlm.nih.gov/11305241
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 23(6)
A simulation study was carried out to determine the impact of various design factors on the accuracy and precision with which population pharmacokinetic parameters are estimated in preclinical pharmacokinetic studies. A drug given by intravenous bolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87202fc8dbf3c43e36d2c94011a51c4
https://pubmed.ncbi.nlm.nih.gov/8733946
https://pubmed.ncbi.nlm.nih.gov/8733946
Publikováno v:
British Journal of Clinical Pharmacology. 54:1-2
Educational reform has taken place in many Medical Schools. A traditional passive approach has been replaced by a more active, student-centred approach, founded on Problem-Based Learning. This has not been without risk because many well-structured co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edafab879d87b8b01efd587e19796aac
https://doi.org/10.1046/j.1365-2125.2002.01586.x
https://doi.org/10.1046/j.1365-2125.2002.01586.x
Publikováno v:
The Annals of pharmacotherapy. 27(9)
OBJECTIVE: To develop new approaches for evaluating results obtained from simulation studies used to determine sampling strategies for efficient estimation of population pharmacokinetic parameters. METHODS: One-compartment kinetics with intravenous b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b311953a6aa0845d0694030f8c00ee97
https://pubmed.ncbi.nlm.nih.gov/8117353
https://pubmed.ncbi.nlm.nih.gov/8117353
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 21(2)
A prospective simulation study has been carried out to evaluate the effect of potential misspecification of the absorption rate constant (ka) in population pharmacokinetic analysis when few to no concentration-time data were available in the absorpti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7442db504ce967226b6dcd7f9e46ed
https://pubmed.ncbi.nlm.nih.gov/8229681
https://pubmed.ncbi.nlm.nih.gov/8229681
Publikováno v:
Cancer chemotherapy and pharmacology. 29(5)
Population pharmacokinetic analysis of the anticancer agent epirubicin was carried out using the program NONMEM. Data were available from 36 patients aged 20–73 years, of whom 23 were women. All subjects exhibited normal liver and renal function. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc0e1cc9d2f38ad26ca6510c4d16ccf
https://pubmed.ncbi.nlm.nih.gov/1551178
https://pubmed.ncbi.nlm.nih.gov/1551178