Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Brian W. Vogler"'
Autor:
Antonio Jimeno, Aik-Choon Tan, Marileila Varella-Garcia, Barbara A. Frederick, Francois Wilhelm, Dara L. Aisner, Sarah M. Takimoto, Daniel Sehrt, Brian W. Vogler, Gregory N. Gan, Justin Eagles-Soukup, Adrian Umpierrez, Phuong Le, J. Jason Morton, David P. Astling, Magdalena J. Glogowska, Daniel W. Bowles, Stephen B. Keysar, Ryan T. Anderson
PDF file - 64K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8e7717de4950956e210d0d4a5249dc
https://doi.org/10.1158/1535-7163.22497478
https://doi.org/10.1158/1535-7163.22497478
Autor:
Antonio Jimeno, Aik-Choon Tan, Marileila Varella-Garcia, Barbara A. Frederick, Francois Wilhelm, Dara L. Aisner, Sarah M. Takimoto, Daniel Sehrt, Brian W. Vogler, Gregory N. Gan, Justin Eagles-Soukup, Adrian Umpierrez, Phuong Le, J. Jason Morton, David P. Astling, Magdalena J. Glogowska, Daniel W. Bowles, Stephen B. Keysar, Ryan T. Anderson
The dual pathway inhibitor rigosertib inhibits phosphoinositide 3-kinase (PI3K) pathway activation as well as polo-like kinase 1 (PLK1) activity across a broad spectrum of cancer cell lines. The importance of PIK3CA alterations in squamous cell carci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36906326f4b2438531275d5ad4819da3
https://doi.org/10.1158/1535-7163.c.6535627.v1
https://doi.org/10.1158/1535-7163.c.6535627.v1
Autor:
Antonio Jimeno, Wells A. Messersmith, S. Gail Eckhardt, Manoj Maniar, Francois Wilhelm, Aik-Chook Tan, Chen Ren, Dara L. Aisner, Elizabeth Freas, Stephen B. Keysar, Brian W. Vogler, Marileila Varella-Garcia, Lia Gore, Stephen Leong, Ryan T. Anderson, David P. Astling, Colin D. Weekes, Elaine T. Lam, Jennifer R. Diamond, Daniel W. Bowles
Purpose: To determine the pharmacokinetics (PK), maximum tolerated dose (MTD), safety, and antitumor activity of an oral formulation of rigosertib, a dual phosphoinositide 3-kinase (PI3K) and polo-like kinase 1 (Plk1) pathway inhibitor, in patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5821806c41159b147bc979b7d3495244
https://doi.org/10.1158/1078-0432.c.6522141.v1
https://doi.org/10.1158/1078-0432.c.6522141.v1
Autor:
Antonio Jimeno, Wells A. Messersmith, S. Gail Eckhardt, Manoj Maniar, Francois Wilhelm, Aik-Chook Tan, Chen Ren, Dara L. Aisner, Elizabeth Freas, Stephen B. Keysar, Brian W. Vogler, Marileila Varella-Garcia, Lia Gore, Stephen Leong, Ryan T. Anderson, David P. Astling, Colin D. Weekes, Elaine T. Lam, Jennifer R. Diamond, Daniel W. Bowles
Supplemental Figure S1: Supplemental Figure 1 shows the pharmacokinetic plasma concentration curve following a single dose of oral rigosertib, revealing dose-dependent pharmacokinetics; Supplemental Table S1: This file provides individual patient cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6aba3c32b70b6fb714ad732fb1c09e2
https://doi.org/10.1158/1078-0432.22451247.v1
https://doi.org/10.1158/1078-0432.22451247.v1
Autor:
Antonio Jimeno, Xiao-Jing Wang, John I. Song, Andrew Thorburn, M. Scott Lucia, Fred R. Hirsch, Hilary Serracino, Justin R. Eagles-Soukup, Gregory N. Gan, Daniel B. Sehrt, Sarah M. Takimoto, Magdalena J. Glogowska, Pamela Fernandez, Jackie Thorburn, Brian W. Vogler, Jeramiah J. Paylor, Daniel W. Bowles, J. Jason Morton, Ryan T. Anderson, Phuong N. Le, Stephen B. Keysar
PDF file - 1255K, Confirmation of GLI1 modulation by EGFR activation (S1); Epithelial gene expression profile and morphology predicts erlotinib sensitivity in HNSCC cell lines (S2); Zeb1 transcription factor is key driver of EGF induced EMT (S3); EGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974366581a1d358ebdce703ca2a05791
https://doi.org/10.1158/0008-5472.22397691.v1
https://doi.org/10.1158/0008-5472.22397691.v1
Autor:
Antonio Jimeno, Xiao-Jing Wang, John I. Song, Andrew Thorburn, M. Scott Lucia, Fred R. Hirsch, Hilary Serracino, Justin R. Eagles-Soukup, Gregory N. Gan, Daniel B. Sehrt, Sarah M. Takimoto, Magdalena J. Glogowska, Pamela Fernandez, Jackie Thorburn, Brian W. Vogler, Jeramiah J. Paylor, Daniel W. Bowles, J. Jason Morton, Ryan T. Anderson, Phuong N. Le, Stephen B. Keysar
PDF file - 113K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eed4e61fefdacf8cbcfedd4601c284d
https://doi.org/10.1158/0008-5472.22397694.v1
https://doi.org/10.1158/0008-5472.22397694.v1
Autor:
Antonio Jimeno, Xiao-Jing Wang, John I. Song, Andrew Thorburn, M. Scott Lucia, Fred R. Hirsch, Hilary Serracino, Justin R. Eagles-Soukup, Gregory N. Gan, Daniel B. Sehrt, Sarah M. Takimoto, Magdalena J. Glogowska, Pamela Fernandez, Jackie Thorburn, Brian W. Vogler, Jeramiah J. Paylor, Daniel W. Bowles, J. Jason Morton, Ryan T. Anderson, Phuong N. Le, Stephen B. Keysar
PDF file - 29K, EGFR dependent EMT quantified as percent Vimentin-positive cells in culture (S1); Combination therapy delays or blocks tumor re-growth in sensitive xenografts (S2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f5d776b371154deba8c0b472f98116
https://doi.org/10.1158/0008-5472.22397688
https://doi.org/10.1158/0008-5472.22397688
Publikováno v:
Algal Research. 36:152-158
As a result of a secondary endosymbiosis of a red alga, stramenopiles retained β-1,3 glucans as the primary soluble storage carbohydrate, in contrast to the starch and glycogen of green plants and animals. This storage carbohydrate has been identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f4a3a6b01e544e789ed6b1d70c184a
https://doi.org/10.1016/j.algal.2018.10.011
https://doi.org/10.1016/j.algal.2018.10.011
Publikováno v:
Algal Research. 58:102385
Nannochloropsis species have garnered significant interest for biofuel production due to their ability to accumulate high levels of triacylglycerols (TAGs), especially following nitrogen-starvation. However, the first response to nutrient starvation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42965b52cc9fa95f22ba115ba27db0f2
https://doi.org/10.1016/j.algal.2021.102385
https://doi.org/10.1016/j.algal.2021.102385
Autor:
Mark P. Stoykovich, Graham J. Henry, Brian W. Vogler, Matthew C. Posewitz, Max I. Keirn, Annika J. Denham, Kathryn L. Morrissey, Yuta Inaba
Publikováno v:
Algal Research. 11:304-312
Flocculation provides an attractive route for the primary dewatering of dilute suspensions of microalgae and cyanobacteria, however, economical harvesting and separations remain challenging. In this article, recyclable flocculants are demonstrated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad139affe84bdaf6d18b6dd31b0e03c
https://doi.org/10.1016/j.algal.2015.07.009
https://doi.org/10.1016/j.algal.2015.07.009