Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Brian W. Strassle"'
Autor:
David von Schack, Michael J Agostino, B Stuart Murray, Yizheng Li, Padmalatha S Reddy, Jin Chen, Sung E Choe, Brian W Strassle, Christine Li, Brian Bates, Lynn Zhang, Huijuan Hu, Smita Kotnis, Brendan Bingham, Wei Liu, Garth T Whiteside, Tarek A Samad, Jeffrey D Kennedy, Seena K Ajit
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17670 (2011)
Neuropathic pain resulting from nerve lesions or dysfunction represents one of the most challenging neurological diseases to treat. A better understanding of the molecular mechanisms responsible for causing these maladaptive responses can help develo
Externí odkaz:
https://doaj.org/article/eb2ca94931af404d80273a0111199401
Autor:
Joan Btesh, Pranab K. Chanda, Evguenia Kouranova, Michael J. Piesla, Ying Gao, Robert H. Ring, Brendan Bingham, Lilly Mark, Garth Whiteside, Dianne Kowal, Mei-Yi Zhang, Albert J. Uveges, Brian W. Strassle, Jeffrey D. Kennedy, Tarek A. Samad, Brian Bates, David S. Garbe, Peimin Lu, Menelas N. Pangalos
Publikováno v:
Molecular Pharmacology. 78:996-1003
Endocannabinoids are lipid molecules that serve as natural ligands for the cannabinoid receptors CB1 and CB2. They modulate a diverse set of physiological processes such as pain, cognition, appetite, and emotional states, and their levels and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49815e89ef0af9c7b55236064f31c3e6
https://doi.org/10.1124/mol.110.068304
https://doi.org/10.1124/mol.110.068304
Autor:
G H Johnston, Eugene John Trybulski, John C. L. Erve, Brian W. Strassle, A. Adedoyin, Jeffrey D. Kennedy, James E. Harrison, Claudine Pulicicchio, Michael J. Piesla, Peimin Lu, Kathryn E. Rogers, Puwen Zhang, Brian J. Platt, Terri Cummons, Garth T. Whiteside, Liza Leventhal, Chad E. Beyer, Zoë A. Hughes, Darlene C. Deecher, L Manzino, Lilly Mark, Jason M. Dwyer
Publikováno v:
British Journal of Pharmacology. 160:1105-1118
Background and purpose: Antidepressants, which raise the CNS concentrations of 5-HT and noradrenaline, are frequently used in the treatment of chronic pain; however, it is not known if increasing CNS noradrenaline levels alone is sufficient for effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4f60e6b8a1f1b1cc97f891a5bd642c1
https://doi.org/10.1111/j.1476-5381.2010.00690.x
https://doi.org/10.1111/j.1476-5381.2010.00690.x
Publikováno v:
Neuroscience. 153:1008-1019
Hyperpolarization-activated cyclic nucleotide-gated channels (HCN) are responsible for the functional hyperpolarization-activated current (I(h)) in dorsal root ganglion (DRG) neurons. We studied HCN1-4 channel mRNA and protein expression and correlat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d71ec4c1cfab6ab85896752290e8c5a
https://doi.org/10.1016/j.neuroscience.2008.03.032
https://doi.org/10.1016/j.neuroscience.2008.03.032
Autor:
Garth T. Whiteside, He Y, Philip G. Jones, Shaiu-Ching Sun, Albert J. Uveges, Brian W. Strassle, Lynn Resnick, Peimin Lu, Jeffrey D. Kennedy, Valerie Smith, Brendan Bingham, Terri Cummons, James E. Harrison, Michael J. Piesla, Chlenov M, Smita Kotnis
Publikováno v:
British Journal of Pharmacology. 151:1061-1070
Background and purpose: Racemic (R,S) AM1241 is a cannabinoid receptor 2 (CB2)-selective aminoalkylindole with antinociceptive efficacy in animal pain models. The purpose of our studies was to provide a characterization of R,S-AM1241 and its resolved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892f970e87a2cd519240b4ab50d7eea6
https://doi.org/10.1038/sj.bjp.0707303
https://doi.org/10.1038/sj.bjp.0707303
Autor:
William Adams, Terri Cummons, Adedayo Adedoyin, Valerie Smith, Nicole R. Sullivan, Liza Leventhal, Taylor Spangler, Garth Whiteside, Shaiu-Ching Sun, Albert J. Uveges, James H. Harrison, Jonathan Schantz, Brian W. Strassle, Alena Barry, Rana Ramdass, Peimin Lu, Philip G. Jones, Michael J. Piesla
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:1294-1304
Here, we have investigated the in vitro pharmacology of a muscarinic agonist, (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983), and we demonstrated its activity in several models of pain. WAY-132983 had a similar a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7102703eae594820ecea62286159f5d3
https://doi.org/10.1124/jpet.106.118604
https://doi.org/10.1124/jpet.106.118604
Publikováno v:
The Journal of Comparative Neurology. 484:144-155
Potassium channels are key determinants of neuronal excitability. We recently identified KChIPs as a family of calcium binding proteins that coassociate and colocalize with Kv4 family potassium channels in mammalian brain (An et al. [2000] Nature 403
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae34acc7aaa0b7cc723197c651f7e91
https://doi.org/10.1002/cne.20443
https://doi.org/10.1002/cne.20443
Autor:
Karen I. Carroll, Lisa C. Doliveira, Michael M. Monaghan, Jie Cao, Kenneth J. Rhodes, Brian W. Strassle, Lynn Buchwalder, Milena Menegola, Sharon L. Burke, M. Amy Sung, W. Frank An, James S. Trimmer
Publikováno v:
The Journal of Neuroscience. 24:7903-7915
Voltage-gated potassium (Kv) channels from the Kv4, orShal-related, gene family underlie a major component of the A-type potassium current in mammalian central neurons. We recently identified a family of calcium-binding proteins, termed KChIPs (Kv ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22570bc0308c37cbbe1d14106f7d2159
https://doi.org/10.1523/jneurosci.0776-04.2004
https://doi.org/10.1523/jneurosci.0776-04.2004
Autor:
Zewditu Bekele-Arcuri, Kenneth J. Rhodes, Brian W. Strassle, Maria F. Matos, Louis N. Manganas, James S. Trimmer, Michael M. Monaghan
Publikováno v:
Neuropharmacology. 35:851-865
Molecular characterization of mammalian voltage-sensitive K + channel genes and their expression became possible with the cloning of the Shaker locus of Drosophila . However, analysis of the expression patterns and subunit composition of native K + c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179a5f0d7934ddf978a418efe00f00b8
https://doi.org/10.1016/0028-3908(96)00128-1
https://doi.org/10.1016/0028-3908(96)00128-1
Autor:
Brian W. Strassle, Liza Leventhal
Publikováno v:
Current Protocols in Pharmacology
Interstitial cystitis (IC) is a chronic pelvic-perineal pain syndrome of unknown etiology that mainly targets the lower urinary tract. It is characterized by urinary frequency and urgency, inflammation, stiffening of the bladder wall, and visceral pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1b457f2f7c72b51a1f12acf6a2c4a3
https://pubmed.ncbi.nlm.nih.gov/22294232
https://pubmed.ncbi.nlm.nih.gov/22294232