Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Brian W. Pack"'
Publikováno v:
Hand in Hand zum Ziel – einfach.besser.messbar www.diabeteskongress.de.
Publikováno v:
Diabetes. 70
Background and Aims: Nasal glucagon is a ready-to-use, drug-device combination therapy for the treatment of severe hypoglycemia. Portability is key, as nasal glucagon should be carried by persons with diabetes at all times. In designing for portabili
Autor:
Kevin C. White, Paul A. Stroud, Brian W. Pack, David C. Sperry, Mark Schrad, Yelizaveta Babayan, Aktham Aburub
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 142:307-314
The purpose of this work was to develop a meaningful in vitro dissolution method for evacetrapib spray-dried dispersion (SDD) tablets that is discriminating for crystalline drug substance (DS) content. Justification of the method conditions included
Autor:
Boris A. Czeskis, Demetrio Ortega, Brian W. Pack, Aktham Aburub, Chris Ward, David S. Small, Ellen A. Cannady, Syeda L. Begum, William F. Annes, Jane Royalty, Qun Lin, Kenneth J. Ruterbories, Chris Hinds, Jeffrey G. Suico
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:238-244
This open-label, single-period study in healthy subjects estimated evacetrapib absolute bioavailability following simultaneous administration of a 130-mg evacetrapib oral dose and 4-h intravenous (IV) infusion of 175 µg [(13) C8 ]-evacetrapib as a t
Autor:
Anjali Agrawal, Stan Altan, Steven W. Baertschi, Chandan Bhugra, Ricardo Borjas, John Campbell, Dana Carabillo, Juan Chen, Lilan H. Chen, Donald Clancy, Elise Clement, Stephen T. Colgan, David Curran, Gena Dalziel, Mayur Dudhedia, Sudharsan Dwaraknath, Anita L. Freed, Paul Gerst, Michael Hawley, Evan M. Hetrick, Cherokee S. Hoaglund Hyzer, Gordon Hutton, Madhuri Jerfy, Satish Kamath, Ammar Khawam, Todd Lewis, Hanlin Li, Julie Lippke, Bruce C. MacDonald, Llurellyn Malcolm, Keith Masse, Tony Mazzeo, Andrew P. Monahan, Ewa Nauka, Rachel Orr, Brian W. Pack, Jeegna Patel-Jones, Jackson D. Pellett, William R. Porter, Fenghe Qiu, Jeffrey C. Roberts, Samantha Rusk, Kevin O. Ryan, Kevin Ryan, Robert Schwabe, Garry Scrivens, Ashish Soman, Jon T. Swanson, Zhixin Jessica Tan, Martyn Ticehurst, Robert J. Timpano, Bryan S. Wicks, Zeena Williams, Chad N. Wolfe, Gavin Wood, Zufan Steven Wu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddf3d76a1a8cc8978d2bef65c0f977b9
https://doi.org/10.1016/b978-0-12-802786-8.09988-5
https://doi.org/10.1016/b978-0-12-802786-8.09988-5
Autor:
Patrick J. Jansen, Mark A. Strege, Allison L. Dill, Linda M. Osborne, Tim A. Smitka, Jerry R. Draper, Evan M. Hetrick, Brian W. Pack, Jonas Y. Buser, Robert M. Montgomery, Steven W. Baertschi
Publikováno v:
Organic Process Research & Development. 19:1458-1464
Galunisertib is a kinase inhibitor designed to selectively inhibit TGF-β signaling. Drug substance stress degradation studies performed during clinical development demonstrated two degradation products via oxidation of the nitrogen(s) of the pyridin
Publikováno v:
TrAC Trends in Analytical Chemistry. 49:126-136
Mass balance is an important concept in pharmaceutical development, but it often proves challenging to assess accurately. This article explores the various methods by which mass balance can and should be measured, expressed, and evaluated in conjunct
Publikováno v:
Journal of Pharmaceutical Sciences. 102:2608-2621
The color of pharmaceutical dosage forms can be an important aspect of product branding and patient compliance with a dosing regimen. During the development of drug products, it is important to understand the stability of not only the active pharmace
Autor:
Francesca E. Wright, Brian W. Pack, Lara D. Penn, Gregory S. Gorman, Teresa R. Henry, Jason R. Conerty
Publikováno v:
The AAPS journal. 18(6)
Non-clinical dose formulations (also known as pre-clinical or GLP formulations) play a key role in early drug development. These formulations are used to introduce active pharmaceutical ingredients (APIs) into test organisms for both pharmacokinetic
Autor:
Ellen A, Cannady, Aktham, Aburub, Chris, Ward, Chris, Hinds, Boris, Czeskis, Kenneth, Ruterbories, Jeffrey G, Suico, Jane, Royalty, Demetrio, Ortega, Brian W, Pack, Syeda L, Begum, William F, Annes, Qun, Lin, David S, Small
Publikováno v:
Journal of Labelled Compounds & Radiopharmaceuticals
This open-label, single-period study in healthy subjects estimated evacetrapib absolute bioavailability following simultaneous administration of a 130-mg evacetrapib oral dose and 4-h intravenous (IV) infusion of 175 µg [(13) C8 ]-evacetrapib as a t