Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Brian W. Howell"'
Autor:
Yeshwant Kurhe, Mara Caputo, Emmelie Cansby, Ying Xia, Sima Kumari, Sumit Kumar Anand, Brian W. Howell, Hanns-Ulrich Marschall, Margit Mahlapuu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 405-423 (2022)
Background & Aims: Hepatocellular carcinoma (HCC) is one of the most fatal and fastest-growing cancers. Recently, nonalcoholic steatohepatitis (NASH) has been recognized as a major catalyst for HCC. Thus, additional research is critically needed to i
Externí odkaz:
https://doaj.org/article/2aae9a7a51ed423ebe5176502440c120
Autor:
Sanghee Lim, Nicole Hermance, Tenny Mudianto, Hatim M. Mustaly, Ian Paolo Morelos Mauricio, Marc A. Vittoria, Ryan J. Quinton, Brian W. Howell, Hauke Cornils, Amity L. Manning, Neil J. Ganem
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Hippo pathway inactivation plays a role in many cancers, although how tumor cells depress signaling is unclear. Here, Lim et al. identify STK25, which activates LATS in a manner distinct from other upstream kinases and is focally deleted from a range
Externí odkaz:
https://doaj.org/article/fb44cfbe9f3a4df592b8189461124a06
Autor:
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Margit Mahlapuu
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis of DKD; however, the
Externí odkaz:
https://doaj.org/article/76ee7c613d244adda29bbfe316fe4d15
Autor:
Miriam Sartages, Mar García-Colomer, Cristina Iglesias, Brian W. Howell, Manuel Macía, Patricia Peña, Celia M. Pombo, Juan Zalvide
Publikováno v:
Stroke. 53:976-986
Background: Cavernous cerebral malformations can arise because of mutations in the CCM1 , CCM2 , or CCM3 genes, and lack of Cdc42 has also been reported to induce these malformations in mice. However, the role of the CCM3 (cerebral cavernous malforma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665525ec3468e48de1788405d8e5e80f
https://doi.org/10.1161/strokeaha.121.036940
https://doi.org/10.1161/strokeaha.121.036940
Autor:
Ying Xia, Margit Mahlapuu, Hanns-Ulrich Marschall, Yeshwant Kurhe, Sumit Kumar Anand, Brian W. Howell, Mara Caputo, Sima Kumari, Emmelie Cansby
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 405-423 (2022)
Background & Aims Hepatocellular carcinoma (HCC) is one of the most fatal and fastest-growing cancers. Recently, nonalcoholic steatohepatitis (NASH) has been recognized as a major catalyst for HCC. Thus, additional research is critically needed to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8324f69ff2ef3f0831e5fa6bb46cc83a
https://doi.org/10.1016/j.jcmgh.2021.09.018
https://doi.org/10.1016/j.jcmgh.2021.09.018
Autor:
Leigh Dairaghi, Ellen Flannery, Paolo Giacobini, Aybike Saglam, Hassan Saadi, Stephanie Constantin, Filippo Casoni, Brian W. Howell, Susan Wray
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
One key signaling pathway known to influence neuronal migration involves the extracellular matrix protein Reelin. Typically, signaling of Reelin occurs via apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor (VLDLR), and th
Externí odkaz:
https://doaj.org/article/0b0358c3a2c148baab286a89ae2019b9
Publikováno v:
J Neurosci
Precise control of neuronal migration is required for the laminar organization of the neocortex and critical for brain function. We previously reported that the acute disruption of theStk25gene (Stk25conditional knock-out; cKO) during mouse embryogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c885ac3f7eed53571b78b2b02cb7fb1
https://doi.org/10.1523/jneurosci.0523-21.2021
https://doi.org/10.1523/jneurosci.0523-21.2021
Publikováno v:
Molecular Neurobiology
Fetal alcohol syndrome (FAS) is characterized by disrupted fetal brain development and postnatal cognitive impairment. The targets of alcohol are diverse, and it is not clear whether there are common underlying molecular mechanisms producing these di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a805d813a434a6da4093d057661be272
https://doi.org/10.1007/s12035-021-02467-x
https://doi.org/10.1007/s12035-021-02467-x
Autor:
Matthew Bracher-Smith, Ganna Leonenko, Emily Baker, Karen Crawford, Andrew C. Graham, Dervis A. Salih, Brian W. Howell, John Hardy, Valentina Escott-Price
The APOE-ε4 allele is known to predispose to amyloid deposition and consequently is strongly associated with Alzheimer's disease (AD) risk. There is debate as to whether the APOE gene accounts for all genetic variation of the APOE locus. Another que
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6222afaffb3af24f0462cc0d0b863ff4
https://orca.cardiff.ac.uk/id/eprint/151606/4/1-s2.0-S0197458022001634-main.pdf
https://orca.cardiff.ac.uk/id/eprint/151606/4/1-s2.0-S0197458022001634-main.pdf
Autor:
Dawn B. Lammert, Brian W Howell
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
RELN encodes a large, secreted glycoprotein integral to proper neuronal positioning during development and regulation of synaptic function postnatally. Rare, homozygous, null mutations lead to lissencephaly with cerebellar hypoplasia, accompanied by
Externí odkaz:
https://doaj.org/article/adf9313b7bba4c66b067668fdd293132