Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Brian W. Fox"'
Autor:
Brian W. Fox, M. Fox
The study of tumour resistance to anticancer drugs has been the subject of many publications since the initial discovery of the phenomenon by J. H. Burchenal and colleagues in 1950. Many papers have been published since then reporting development of
Autor:
Brian W Fox
Publikováno v:
Clinical Oncology. 10:115-124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a50e6cd85ae15684cb730501aea1ef6
https://doi.org/10.1016/s0936-6555(05)80492-3
https://doi.org/10.1016/s0936-6555(05)80492-3
Publikováno v:
Synthetic Communications. 26:49-62
Several anthraquinones, which occur in plants used to treat cancer in traditional Chinese Medicine, have been synthesised and tested for cytotoxicity in two mammalian cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f9d7a0b6318344fd6df24d8da868d23
https://doi.org/10.1080/00397919608003861
https://doi.org/10.1080/00397919608003861
Publikováno v:
British Journal of Cancer
A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd84a4a4c95cd9f3a635ad6a3747dc71
http://europepmc.org/articles/PMC2033763
http://europepmc.org/articles/PMC2033763
Autor:
Brian W Fox, Alan T McGown, John A. Hadfield, Philip J Perry, C Whitworth, Vasilios H Pavlidis
Publikováno v:
Anti-Cancer Drugs. 5:533-538
Eight benzoxazin-4-ones related in structure to NSC 341964 (1) have been tested for cytotoxicity in two different cell systems. Two of the benzoxazin-4-ones (3 and 10) showed good cytotoxicity (ID50 = 9.9 and 8.9 microM) in P388 cells. The nitrobenzo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca9b871ad10b4e92959e70757932c18
https://doi.org/10.1097/00001813-199410000-00004
https://doi.org/10.1097/00001813-199410000-00004
Autor:
Brian W Fox, Gordon C Jayson, Derek Crowther, George R. Pettit, Peter L. Stern, Joseph A Prendiville, Christof Scheid
Publikováno v:
Cancer Immunology Immunotherapy. 39:223-230
Bryostatin 1 is a protein kinase C activator that inhibits growth of tumour cells and activates lymphocytes in vitro, properties that have encouraged its use in phase 1 clinical studies as an anticancer agent. We investigated interleukin-2(IL-2)-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec4851f47c1f317da653b5267fd66fc
https://doi.org/10.1007/bf01525985
https://doi.org/10.1007/bf01525985
Publikováno v:
International Journal of Gynecological Cancer. 4:241-249
This work compares glutathione levels, glutathione S-transferase activities and isoenzyme expression, metallothionein levels and P-glycoprotein expression in normal ovaries, and in epithelial ovarian tumor biopsies from patients prior to chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a526e20999adb3e7c3b590ed244b4e3c
https://doi.org/10.1046/j.1525-1438.1994.04040241.x
https://doi.org/10.1046/j.1525-1438.1994.04040241.x
Autor:
Derek Crowther, D Murphy, Brian W Fox, John D. Norton, Bartrum W. Baker, J Renninson, Alan T McGown
Publikováno v:
British Journal of Cancer
Approximately 30-50% of cases of ovarian adenocarcinoma harbour mutations in the p53 tumour-suppressor gene associated with elevated levels of the protein detected by immunohistochemical staining. To investigate any relation between the presence of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f802974850684c665a1756dbd57e2c
http://europepmc.org/articles/PMC1968836
http://europepmc.org/articles/PMC1968836
Publikováno v:
Journal of Obstetrics and Gynaecology. 13:126-129
SummaryGlutathione levels were measured in human malignant ovarian tumours obtained either at initial debulking surgery, before cytotoxic chemotherapy, or at second look laparotomy following chemotherapy. The response rates of these two groups to che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc7219675a6f3dc562b12b19f0d207db
https://doi.org/10.3109/01443619309151800
https://doi.org/10.3109/01443619309151800
Publikováno v:
Biochemical Pharmacology. 45:253-256
The glutathione contents, glutathione S -transferase activities and metallothionein contents have been measured in a series of L1210 cell lines which show decreased sensitivities to platinum drugs. Resistance to cisplatinum cisDDP, cis -diamminedichl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd3b6effaec9bc025ee4521029ad885
https://doi.org/10.1016/0006-2952(93)90399-h
https://doi.org/10.1016/0006-2952(93)90399-h