Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Brian W Guzik"'
Autor:
Francesca Barone, Paul P Tak, Sean Lawler, James A Lederer, Marilin S Koch, Mykola Zdioruk, Michal O Nowicki, Alec M Griffith, Estuardo Aguilar, Laura K Aguilar, Brian W Guzik, E Antonio Chiocca
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/06519b4a8e9e4394bfe536ab62aa59b5
Autor:
Marilin S. Koch, Mykola Zdioruk, Michal O. Nowicki, Alec M. Griffith, Estuardo Aguilar-Cordova, Laura K. Aguilar, Brian W. Guzik, Francesca Barone, Paul Peter Tak, Katharina Schregel, Michael S. Hoetker, James A. Lederer, E. Antonio Chiocca, Ghazaleh Tabatabai, Sean E. Lawler
Publikováno v:
Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 275-288 (2022)
CAN-2409 is a replication-deficient adenovirus encoding herpes simplex virus (HSV) thymidine kinase (tk) currently in clinical trials for treatment of glioblastoma. The expression of tk in transduced cancer cells results in conversion of the pro-drug
Externí odkaz:
https://doaj.org/article/d1ff12c2b9db4d9895906f9830d6592e
Autor:
Mitchell G. Bryski, Jason Stadanlick, Brian W. Guzik, Patrick Woodruff, Lydia G. Frenzel-Sulyok, Edmund K. Moon, Laura K. Aguilar, Charuhas Deshpande, Estuardo Aguilar-Cordova, Steven M. Albelda, Evgeniy Eruslanov, Andrea G. Manzanera, Corey J. Langer, Jarrod D. Predina, Sunil Singhal, Marina Martinez, Andrew R. Haas, Christopher Corbett, Shaun O'Brien
Publikováno v:
Molecular Therapy
Gene-mediated cytotoxic immunotherapy (GMCI) is an immuno-oncology approach involving local delivery of a replication-deficient adenovirus expressing herpes simplex thymidine kinase (AdV-tk) followed by anti-herpetic prodrug activation that promotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a9e6c798bf28eac1e5e6c327b25bfd
http://europepmc.org/articles/PMC7854297
http://europepmc.org/articles/PMC7854297
Autor:
Marilin S Koch, Mykola Zdioruk, Michal O Nowicki, Alec M Griffith, Estuardo Aguilar, Laura K Aguilar, Brian W Guzik, Francesca Barone, Paul P Tak, Ghazaleh Tabatabai, James A Lederer, E Antonio Chiocca, Sean Lawler
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
BackgroundIntratumoral viral oncolytic immunotherapy is a promising new approach for the treatment of a variety of solid cancers. CAN-2409 is a replication-deficient adenovirus that delivers herpes simplex virus thymidine kinase to cancer cells, resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b8be09b80beec58beda1af9d511f57
https://pubmed.ncbi.nlm.nih.gov/35017150
https://pubmed.ncbi.nlm.nih.gov/35017150
Autor:
Laura K. Aguilar, Ghazaleh Tabatabai, Marilin Koch, Brian W. Guzik, Michał Nowicki, Estuardo Aguilar-Cordova, Sean E. Lawler, E. Antonio Chiocca, Mikolay Zdioruk
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Gene-mediated cytotoxic immunotherapy (GMCI) is a local tumor immunotherapy that uses aglatimagene besadenovec (a non-replicating serotype 5 adenovirus, expressing HSV1 thymidine kinase) with the prodrug ganciclovir to induce DNA double st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df794863829b5af32bedde886ad58c49
https://doi.org/10.1136/jitc-2020-sitc2020.0468
https://doi.org/10.1136/jitc-2020-sitc2020.0468
Autor:
Estuardo Aguilar-Cordova, Serena Desideri, Pierpaolo Peruzzi, Patrick Y. Wen, Wenya Linda Bi, Frank S. Lieberman, Ian Lee, James Snyder, Steven Brem, Paul Peter Tak, Sean E. Lawler, Susan Bell, Stephen J Bagley, Nirav J. Patel, Andrea G. Manzanera, E. Antonio Chiocca, Francesca Barone, Nduka Amankulor, Lenika Lopez, L. Burt Nabors, Megan Mantica, Neeraja Danda, Brian W. Guzik, Stephen B. Tatter, Stuart A. Grossman, Tobias Walbert, Laura K. Aguilar, Roy E. Strowd, Lixian Jin, Arati Desai, William Timmer, Xiaobu Ye, David A. Reardon
Publikováno v:
Neuro-Oncology. 23:vi52-vi52
BACKGROUND CAN-2409 is a replication-deficient adenovirus that delivers HSV thymidine kinase to cancer cells, resulting in local conversion of orally administered valacyclovir into a toxic metabolite. Previously, a phase 1b/2 clinical trial of CAN-24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::878ef996c3d5f0cfe21fd7134a1d39b1
https://doi.org/10.1093/neuonc/noab196.205
https://doi.org/10.1093/neuonc/noab196.205
Autor:
Jared Woods, Hiroshi Nakashima, David A. Reardon, Sean E. Lawler, Sascha Marx, Anita Giobbie-Hurder, Yu Zeng, Patrick Y. Wen, E. Antonio Chiocca, Jessica Dwyer, Daniel Triggs, Mario L. Suvà, Isaac Soloman, Scott J. Rodig, Kai W. Wucherpfennig, Francesca Barone, Simon Gritsch, William Pisano, Eudocia Q. Lee, Nathan Mathewson, Paul Peter Tak, Abigail Tianai Zhang, Estuardo Aguilar-Cordova, Brian W. Guzik, James Grant, Mariano Severgnini, Keith L. Ligon, Laura K. Aguilar, David Krisky
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundRecurrent high-grade glioma (HGG) represents a significant clinical unmet need with expected survival between 6 to 9 months. Oncolytic viruses are a new therapeutic approach for solid tumors that deploy oncolytic activity combined with loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b190074abd8f109e78cb83fbfd6cad
https://doi.org/10.1136/jitc-2021-sitc2021.395
https://doi.org/10.1136/jitc-2021-sitc2021.395
Autor:
Laura K. Aguilar, Mykola Zdioruk, Estuardo Aguilar, Brian W. Guzik, Ennio Antonio Chiocca, M. Oskar Nowicki, Marilin Koch, Sean E. Lawler
Publikováno v:
Neuro Oncol
RATIONALE Dexamethasone is frequently used in symptomatic treatment of glioma patients, although it is known to cause immune suppression. Checkpoint inhibitor immunotherapies have not yet been successful in glioma treatments. Gene-mediated cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c057d00a89eeba5a9a58c937d029712
https://europepmc.org/articles/PMC6847239/
https://europepmc.org/articles/PMC6847239/
Autor:
Andrew R. Haas, Steven M. Albelda, Laura K. Aguilar, Evgeniy Eruslanov, Marina Martinez, Mitchell G. Bryski, Christopher Corbett, Charuhas Deshpande, Brian W. Guzik, Andrea G. Manzanera, Shaun O'Brien, Edmund K. Moon, Jarrod D. Predina, Estuardo Aguilar-Cordova, Sunil Singhal, Lydia Frenzel Sulyok
Publikováno v:
Journal of Clinical Oncology. 38:9050-9050
9050 Background: GMCI is a tumor-specific immuno-oncology approach implemented through local delivery of aglatimagene besadenovec(AdV-tk) followed by anti-herpetic prodrug. This leads to immunogenic tumor cell death, antigen presenting cell activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2506dba56665b912cc0c0b6329dda97
https://doi.org/10.1200/jco.2020.38.15_suppl.9050
https://doi.org/10.1200/jco.2020.38.15_suppl.9050
Autor:
Hiroshi Nakashima, Patrick Y. Wen, David A. Reardon, Michał Nowicki, Brian W. Guzik, Maria Carmela Speranza, Laura K. Aguilar, Gordon J. Freeman, Johanna K. Kaufmann, Franz Ricklefs, Xandra O. Breakefield, Ralph Weissleder, Agnieszka Bronisz, Sarah R. Klein, Carmela Passaro, Prisca Obi, Kazue Kasai, Sean E. Lawler, Abdul-Kareem Ahmed, E. Antonio Chiocca, Estuardo Aguilar-Cordova
Background Combined immunotherapy approaches are promising cancer treatments. We evaluated anti-programmed cell death protein 1 (PD-1) treatment combined with gene-mediated cytotoxic immunotherapy (GMCI) performed by intratumoral injection of a prodr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b872b4788715e55b0f00814efef9d6
https://europepmc.org/articles/PMC5777502/
https://europepmc.org/articles/PMC5777502/