Výsledky vyhledávání - "Brian W Grinnell"

Akademický článek

Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study.

Autor: Josée Bouchard, Rakesh Malhotra, Shamik Shah, Yu-Ting Kao, Florin Vaida, Akanksha Gupta, David T Berg, Brian W Grinnell, Brenda Stofan, Ashita J Tolwani, Ravindra L Mehta

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120770 (2015)

Endothelial dysfunction contributes to the development of acute kidney injury (AKI) in animal models of ischemia reperfusion injury and sepsis. There are limited data on markers of endothelial dysfunction in human AKI. We hypothesized that Protein C

Externí odkaz: https://doaj.org/article/2b4eb4f10f4b4875bf54f11fc5e3fd60

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Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic mice

Autor: Martin S. Cramer, Gangaraju Rajashekhar, George E. Sandusky, David P. Basile, David T. Berg, Timothy A. Sutton, Akanksha Gupta, Jessica L. Friedrich, Brian W. Grinnell, Abby Marin, Antje Willuweit, Matthias Clauss

Publikováno v: American Journal of Physiology-Renal Physiology. 302:F703-F712

Chronic kidney disease pathogenesis involves both tubular and vascular injuries. Despite abundant investigations to identify the risk factors, the involvement of chronic endothelial dysfunction in developing nephropathies is insufficiently explored.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea48f2537f70099099904ea46bb8b75b
https://doi.org/10.1152/ajprenal.00558.2011

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Activated Protein C and Acute Kidney Injury: Selective Targeting of PAR-1

Autor: William L. Macias, Bruce A. Molitoris, Mark D. Williams, Akanksha Gupta, Brian W. Grinnell

Publikováno v: Current Drug Targets. 10:1212-1226

Protein C is a plasma serine protease that when activated plays a central role in modulating the function of the vascular endothelium and its interface with the innate immune system. Activated protein C (APC) has a dual mechanism of action via the fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e4e398f98f2f54d22370ee5aedc1b8
https://doi.org/10.2174/138945009789753291

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Soluble Thrombomodulin Protects Ischemic Kidneys

Autor: Bruce A. Molitoris, Silvia B. Campos, Bryan Edward Jones, Grant McDougal, Brian W. Grinnell, Asif Sharfuddin, Carrie L. Phillips, Ruben M. Sandoval, David T. Berg, Akanksha Gupta

Publikováno v: Journal of the American Society of Nephrology. 20:524-534

Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal injury. Thrombomodulin is a necessary factor in the anticoagulant protein C pathway and has inherent anti-inflammatory properties. We studied the effect of soluble

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ddbb93b04826fc3d72bb3b7eb86359
https://doi.org/10.1681/asn.2008060593

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Distinct Functions of Activated Protein C Differentially Attenuate Acute Kidney Injury

Autor: David T. Berg, Brian W. Grinnell, Samreen K. Syed, Bryan Edward Jones, Barbara A. Swanson, Mark Alan Richardson, Bruce Gerlitz, Christopher Y. S. Bull, Akanksha Gupta, Elizabeth Galbreath

Publikováno v: Journal of the American Society of Nephrology. 20:267-277

Administration of activated protein C (APC) protects from renal dysfunction, but the underlying mechanism is unknown. APC exerts both antithrombotic and cytoprotective properties, the latter via modulation of protease-activated receptor-1 (PAR-1) sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ee9fa89a1c031180985e55198ce855
https://doi.org/10.1681/asn.2008030294

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Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

Autor: Ilya A. Vinnikov, Muhammed Kashif, Berend Isermann, Brian W. Grinnell, Hartmut Weiler, Bruce Gerlitz, Angelika Bierhaus, Charles T. Esmon, Thati Madhusudhan, Janusch Blautzik, Erwin Blessing, Jun Oh, S. Herzog, Triantafyllos Chavakis, Marcus A F Corat, Martin Zeier, Peter P. Nawroth, David T. Berg

Publikováno v: Nature Medicine. 13:1349-1358

Data providing direct evidence for a causative link between endothelial dysfunction, microvascular disease and diabetic end-organ damage are scarce. Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9983b9296daa45c791916992a9f84e05
https://doi.org/10.1038/nm1667

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Polymeric coatings that mimic the endothelium: Combining nitric oxide release with surface-bound active thrombomodulin and heparin

Autor: Biyun Wu, Mark E. Meyerhoff, Brian W. Grinnell, Bruce Gerlitz

Publikováno v: Biomaterials. 28:4047-4055

Multi-functional bilayer polymeric coatings are prepared with both controlled nitric oxide (NO) release and surface-bound active thrombomodulin (TM) alone or in combination with immobilized heparin. The outer-layer is made of CarboSil, a commercially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9712163a6e765a753ece07d5d79091
https://doi.org/10.1016/j.biomaterials.2007.06.002

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ACTIVATED PROTEIN C SUPPRESSES ADRENOMEDULLIN AND AMELIORATES LIPOPOLYSACCHARIDE-INDUCED HYPOTENSION

Autor: Stephen F. Lowry, Mark A. Richardson, Avadhesh C. Sharma, David T. Berg, Akanksha Gupta, Samreen K. Syed, Brian W. Grinnell, Bruce Gerlitz, Elizabeth Galbreath

Publikováno v: Shock. 28:468-476

Activated protein C (APC) is an important modulator of vascular function that has antithrombotic and anti-inflammatory properties. Studies in humans have shown modulation of endotoxin-induced hypotension by recombinant human APC, drotrecogin alfa (ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7aca2febd398b6f70482c426c70c83
https://doi.org/10.1097/shk.0b013e3180487f09

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Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2

Autor: George J. Rhodes, Bruce Gerlitz, Akanksha Gupta, Bruce A. Molitoris, David T. Berg, Brian W. Grinnell

Publikováno v: American Journal of Physiology-Renal Physiology. 293:F245-F254

Endothelial dysfunction contributes significantly to acute renal failure (ARF) during inflammatory diseases including septic shock. Previous studies have shown that activated protein C (APC) exhibits anti-inflammatory properties and modulates endothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921844a63e6c0b6887aa565c148c907d
https://doi.org/10.1152/ajprenal.00477.2006

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