Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Brian W, Jarecki"'
Autor:
Leili Zhang, Qiang Cui, Baron Chanda, Xin Zhou, Xiaoxun Li, Suqing Zheng, Weiping Tang, Brian W. Jarecki
Publikováno v:
Biophysical Journal. 105(12):2724-2732
Measurements of inter- and intramolecular distances are important for monitoring structural changes and understanding protein interaction networks. Fluorescence resonance energy transfer and functionalized chemical spacers are the two predominantly u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cf2a40298627b8ab3270fe1452d087
Publikováno v:
Biophysical Journal. 110(3)
The molecular correlates of the large energy barriers, underlying the strong temperature dependent modulation of activation kinetics of thermp-TRP channels, are virtually unknown. Recent evidence, based on de novo design of a temperature-modulated ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db973d51a89adb8ff41c72a4f5e36641
Publikováno v:
Proceedings of the National Academy of Sciences. 109:2648-2653
Voltage-dependent ion channels are crucial for generation and propagation of electrical activity in biological systems. The primary mechanism for voltage transduction in these proteins involves the movement of a voltage-sensing domain (D), which open
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b145a1c020c28f5e455392c017606de2
https://doi.org/10.1073/pnas.1115575109
https://doi.org/10.1073/pnas.1115575109
Publikováno v:
The Journal of Physiology. 589:597-608
Abnormal pain sensitivity associated with inherited and acquired pain disorders occurs through increased excitability of peripheral sensory neurons in part due to changes in the properties of voltage-gated sodium channels (Navs). Resurgent sodium cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b66118eaf61445e89ca2fbee66d42f6
https://doi.org/10.1113/jphysiol.2010.200915
https://doi.org/10.1113/jphysiol.2010.200915
Publikováno v:
Journal of Clinical Investigation. 120:369-378
Inherited mutations in voltage-gated sodium channels (VGSCs; or Nav) cause many disorders of excitability, including epilepsy, chronic pain, myotonia, and cardiac arrhythmias. Understanding the functional consequences of the disease-causing mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f222e15c2c1f7ad5321e04d623ea2858
https://doi.org/10.1172/jci40801
https://doi.org/10.1172/jci40801
Alternative splicing of NaV1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T
Publikováno v:
Channels. 3:261-269
Alternative splicing is known to alter pharmacological sensitivities, kinetics, channel distribution under pathological conditions, and developmental regulation of VGSCs. Mutations that alter channel properties in Na(V)1.7 have been genetically impli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2227126cf593a2f6fecd0a0c252f9f9f
https://doi.org/10.4161/chan.3.4.9341
https://doi.org/10.4161/chan.3.4.9341
Publikováno v:
Biophysical Journal. 108(2)
Physiological sensation of heat or cold in higher organisms is mediated by specialized ion channels whose opening and closing is exquisitely regulated by ambient temperatures. Members of TRP channel family, a branch of the much larger voltage-gated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf23baf639f0f5d6201e6e246308cd7c
Publikováno v:
Cell. 158(5)
SummaryPerception of heat or cold in higher organisms is mediated by specialized ion channels whose gating is exquisitely sensitive to temperature. The physicochemical underpinnings of this temperature-sensitive gating have proven difficult to parse.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7aefb110634e6c5dae25cefe1afa98b
https://pubmed.ncbi.nlm.nih.gov/25171401
https://pubmed.ncbi.nlm.nih.gov/25171401
Publikováno v:
Scientific Reports
Voltage-gated ion channels are a class of membrane proteins that temporally orchestrate the ion flux critical for chemical and electrical signaling in excitable cells. Current methods to investigate the function of these channels rely on heterologous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3db6aa6a79260fe4c66c76a7d8e3e0
Publikováno v:
Biophysical Journal. 102(3)
Voltage-gated ion channels are crucial for the generation of action potentials in excitable tissues throughout the human body. In response to membrane depolarization, the movement of the voltage-sensors opens a pore gate on the intracellular side of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2123ca739d2b94922b290d98016a80