Genomic and Ecogenomic Characterization of Proteus mirabilis Bacteriophages

Autor: Diana R. Alves, Jonathan Nzakizwanayo, Cinzia Dedi, Chara Olympiou, Aurélie Hanin, Witold Kot, Lars Hansen, Rene Lametsch, Cormac G. M. Gahan, Pascale Schellenberger, Lesley A. Ogilvie, Brian V. Jones

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

Proteus mirabilis often complicates the care of catheterized patients through the formation of crystalline biofilms which block urine flow. Bacteriophage therapy has been highlighted as a promising approach to control this problem, but relatively few

Externí odkaz: https://doaj.org/article/0bf84fc9551d4977a5e00c8dc07a96e4

Development of a High-Throughput ex-Vivo Burn Wound Model Using Porcine Skin, and Its Application to Evaluate New Approaches to Control Wound Infection

Autor: Diana R. Alves, Simon P. Booth, Paola Scavone, Pascale Schellenberger, Jonathan Salvage, Cinzia Dedi, Naing-Tun Thet, A. Toby A. Jenkins, Ryan Waters, Keng W. Ng, Andrew D. J. Overall, Anthony D. Metcalfe, Jonathan Nzakizwanayo, Brian V. Jones

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

Biofilm formation in wounds is considered a major barrier to successful treatment, and has been associated with the transition of wounds to a chronic non-healing state. Here, we present a novel laboratory model of wound biofilm formation using ex-viv

Externí odkaz: https://doaj.org/article/1b2e1f23d5744734befce429e5f8a637

Antibiotic therapy and the gut microbiome: investigating the effect of delivery route on gut pathogens

Autor: Rebecca J. Ingram, Brendan Gilmore, Ryan F. Donnelly, Li Zhao, Brian V. Jones, Ismaiel Tekko, Stephen Kelly, Helen O. McCarthy, Rebecca Weiser, Jonathan Nzakizwanayo, Aoife M. Rodgers

Publikováno v: Kelly, S A, Nzakizwanayo, J, Rodgers, A M, Zhao, L, Weiser, R, Tekko, I A, McCarthy, H O, Ingram, R J, Jones, B V, Donnelly, R F & Gilmore, B F 2021, ' Antibiotic Therapy and the Gut Microbiome : Investigating the Effect of Delivery Route on Gut Pathogens ', ACS infectious diseases, vol. 7, no. 5, pp. 1283–1296 . https://doi.org/10.1021/acsinfecdis.1c00081
Kelly, S A, Nzakizwanayo, J, Rodgers, A M, Zhao, L, Weiser, R, Tekko, I A, McCarthy, H O, Ingram, R J, Jones, B V, Donnelly, R F & Gilmore, B F 2021, ' Antibiotic Therapy and the Gut Microbiome: Investigating the Effect of Delivery Route on Gut Pathogens ', ACS Infectious Diseases, vol. 7, no. 5, pp. 1283-1296 . https://doi.org/10.1021/acsinfecdis.1c00081

The contribution of the gut microbiome to human health has long been established, with normal gut microbiota conferring protection against invasive pathogens. Antibiotics can disrupt the microbial balance of the gut, resulting in disease and the deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb352f56a701111016283c86d389f5a5
https://orca.cardiff.ac.uk/id/eprint/141902/1/Antibiotic+Therapy+and+the+Gut+Microbiome.pdf

A Novel Inducible Prophage from Burkholderia Vietnamiensis G4 is Widely Distributed across the Species and Has Lytic Activity against Pathogenic Burkholderia

Autor: Ashley Otter, Rebecca Weiser, Jonathan P. Salvage, Brian V. Jones, Eshwar Mahenthiralingam, Julian Parkhill, Zhong Ling Yap

Publikováno v: Viruses, Vol 12, Iss 601, p 601 (2020)
Viruses
Volume 12
Issue 6

Burkholderia species have environmental, industrial and medical significance, and are important opportunistic pathogens in individuals with cystic fibrosis (CF). Using a combination of existing and newly determined genome sequences, this study invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e919230e3eb61b9647d0d07e754e53f4
https://www.repository.cam.ac.uk/handle/1810/306947

Derepression of the smvA Efflux System Arises in Clinical Isolates of Proteus mirabilis and Reduces Susceptibility to Chlorhexidine and Other Biocides

Autor: Emma L. Denham, Lucy J. Bock, H. Pelling, Matthew E. Wand, Wendy M. Macfarlane, J.M. Sutton, Brian V. Jones, Jonathan Nzakizwanayo

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

Proteus mirabilis is a common pathogen of the catheterised urinary tract and often described as intrinsically resistant to the biocide chlorhexidine (CHD). Here we demonstrate that de-repression of the smvA efflux system has occurred in clinical isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3770f3c6d2561beb7129f3e952b4e9d9
https://doi.org/10.1128/aac.01535-19