Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Brian V. Harmon"'
Publikováno v:
International Journal of Radiation Biology. 75:973-983
Purpose: To analyse the incidence of radiation-induced apoptosis, expression of two apoptosis-related genes, Bcl-2 and p53, and post-radiation levels of cell proliferation in the neonatal rat (4-5 days old) kidney and testis. Materials and methods: A
Publikováno v:
The Journal of Pathology. 178:176-181
Although insulin-dependent diabetes mellitus (IDDM) results from irreversible loss of beta cells, the mode of cell death responsible for this loss has not previously been categorized. In this study, the multiple low-dose streptozotocin (stz) model (i
Publikováno v:
Cell Proliferation. 27:455-464
The amino acids glutamic acid and tryptophan reportedly reverse the antitumour effect of the cancer chemotherapeutic drug vinblastine. Recent studies have shown that a large part of vinblastine's antitumour effect is due to induction of apoptosis. In
Publikováno v:
Cancer. 73:2013-2026
Apoptosis is a distinct mode of cell death that is responsible for deletion of cells in normal tissues; it also occurs in specific pathologic contexts. Morphologically, it involves rapid condensation and budding of the cell, with the formation of mem
Publikováno v:
Immunology and Cell Biology. 72:35-41
The balance between cell death and cell proliferation is a significant factor in the growth kinetics of normal and neoplastic tissues. Distinction between the two major forms of cell death, necrosis and apoptosis, is now recognized as important in un
Publikováno v:
Pathology. 26:81-89
We counted apoptotic thymic cortical lymphocytes in semi-thin plastic sections of 266 human autopsy thymuses. The decreased patients included in the study were all aged less than 40 yrs and all died within 72 hrs of the onset of symptoms. Based on pu
Publikováno v:
Cell Proliferation. 25:523-536
Although vincristine is widely used clinically in the treatment of some human cancers, its mechanism of action has not been clearly established. In this study, the patterns of cell death induced y vincristine in the intestinal crypts of mice and in a
Publikováno v:
Cell Proliferation. 25:241-250
In this study we examined the possibility that regular or circadian fluctuations occur in the frequency of spontaneous spermatogonial apoptosis. Apoptosis of A2, A3 and A4 type spermatogonia occurring spontaneously in the normal rat testis was studie
Publikováno v:
British Journal of Cancer
A number of reports indicate that protein synthesis is a requirement for the occurrence of apoptosis. In this study, the effect of the protein synthesis inhibitor cycloheximide (CHM) on spontaneous apoptosis of B-chronic lymphocytic leukaemia (B-CLL)
Publikováno v:
International Journal of Radiation Biology. 59:489-501
There is now abundant evidence that apoptosis, the cell death mechanism responsible for physiological deletion of cells, can be triggered by mild hyperthermia. However, the overall importance of this mode of death in heated tumours has not yet been e