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of 48
pro vyhledávání: '"Brian Tjaden"'
Autor:
Brian Tjaden
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Small regulatory RNAs pervade prokaryotes, with the best-studied family of these non-coding genes corresponding to trans-acting regulators that bind via base pairing to their message targets. Given the increasing frequency with which these g
Externí odkaz:
https://doaj.org/article/571c3187925a47619e7f248b58817e98
Autor:
Brian Tjaden
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 77-84 (2023)
Owing to the complexities of bacterial RNA biology, the transcriptomes of even the best studied bacteria are not fully understood. To help elucidate the transcriptional landscape of E. coli, we compiled a compendium of 3,376 RNA-seq data sets compose
Externí odkaz:
https://doaj.org/article/506a90e05f004aedb230fee821b675bd
Autor:
Jacob Tjaden, Brian Tjaden
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294924 (2023)
The democratization of machine learning is a popular and growing movement. In a world with a wealth of publicly available data, it is important that algorithms for analysis of data are accessible and usable by everyone. We present MLpronto, a system
Externí odkaz:
https://doaj.org/article/038dbf0d90f44b7ba96f8ae992feab2d
Autor:
Kathleen Nudel, Ryan McClure, Matthew Moreau, Emma Briars, A. Jeanine Abrams, Brian Tjaden, Xiao-Hong Su, David Trees, Peter A. Rice, Paola Massari, Caroline A. Genco
Publikováno v:
mSphere, Vol 3, Iss 3 (2018)
ABSTRACT Neisseria gonorrhoeae is a bacterial pathogen responsible for the sexually transmitted infection gonorrhea. Emergence of antimicrobial resistance (AMR) of N. gonorrhoeae worldwide has resulted in limited therapeutic choices for this infectio
Externí odkaz:
https://doaj.org/article/355c292415414e6387a0346fd195fb2b
Autor:
Ryan McClure, Kathleen Nudel, Paola Massari, Brian Tjaden, Xiaohong Su, Peter A Rice, Caroline A Genco
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133982 (2015)
Gonorrhea is a highly prevalent disease resulting in significant morbidity worldwide, with an estimated 106 cases reported annually. Neisseria gonorrhoeae, the causative agent of gonorrhea, colonizes and infects the human genital tract and often evad
Externí odkaz:
https://doaj.org/article/93c8f9c0db0b449d8ddc3f6136f4207b
Publikováno v:
Nucleic acids research.
Ligand-binding RNAs (RNA aptamers) are widespread in the three domains of life, serving as sensors of metabolites and other small molecules. When aptamers are embedded within RNA transcripts as components of riboswitches, they can regulate gene expre
Autor:
Brian Tjaden
Publikováno v:
Methods
An operon is a set of neighboring genes in a genome that is transcribed as a single polycistronic message. Genes that are part of the same operon often have related functional roles or participate in the same metabolic pathways. The majority of all b
Autor:
Michael R. Chase, Rushdy Ahmad, Vincent H Lin, Thibault Barbier, Jonathan Livny, Matthew J. Szucs, Brian Tjaden, Sarah M. Fortune, Raylin Xu, Jeremy M. Rock, Josie François, Elias R. Gerrick
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This work describes the most extensive discovery and functional characterization of small regulatory RNAs (sRNAs) in Mycobacterium tuberculosis to date. We comprehensively define the sRNAs expressed in M. tuberculosis under five host-lik
Publikováno v:
Molecular Microbiology. 106:919-937
Summary During environmental adaptation bacteria use small regulatory RNAs (sRNAs) to repress or activate expression of a large fraction of their proteome. We extended the use of the in vivo RNA proximity ligation method towards probing global sRNA i
Autor:
Caroline A. Genco, Matthew R. Moreau, Kathleen Nudel, Xiao-Hong Su, Ryan McClure, David L. Trees, A. Jeanine Abrams, Brian Tjaden, Emma Briars, Paola Massari, Peter A. Rice
Publikováno v:
mSphere, Vol 3, Iss 3 (2018)
mSphere
mSphere, Vol 3, Iss 3, p e00312-18 (2018)
mSphere
mSphere, Vol 3, Iss 3, p e00312-18 (2018)
Recent emergence of antimicrobial resistance of Neisseria gonorrhoeae worldwide has resulted in limited therapeutic choices for treatment of infections caused by this organism. We performed global transcriptomic analysis of N. gonorrhoeae in subjects