Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Brian Tenner"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 10, p e1012564 (2024)
The nanoscale organization of enzymes associated with the dynamics of second messengers is critical for ensuring compartmentation and localization of signaling molecules in cells. Specifically, the spatiotemporal orchestration of cAMP and Ca2+ oscill
Externí odkaz:
https://doaj.org/article/69d096dbe0704104bf2b103765b04b54
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100693- (2021)
Summary: Fluorescence-based sensors are powerful molecular tools for studying the spatiotemporal regulation of cell signaling, which is often organized into discrete microdomains. Here, we present a protocol for using fluorescent sensors targeted to
Externí odkaz:
https://doaj.org/article/278d7d338b494a568d791c09cdb02527
Autor:
Brian Tenner, Michael Getz, Brian Ross, Donya Ohadi, Christopher H Bohrer, Eric Greenwald, Sohum Mehta, Jie Xiao, Padmini Rangamani, Jin Zhang
Publikováno v:
eLife, Vol 9 (2020)
Signaling networks are spatiotemporally organized to sense diverse inputs, process information, and carry out specific cellular tasks. In β cells, Ca2+, cyclic adenosine monophosphate (cAMP), and Protein Kinase A (PKA) exist in an oscillatory circui
Externí odkaz:
https://doaj.org/article/08e44b5ad3c04a598dfea6414b917d7e
Autor:
Brian L Ross, Brian Tenner, Michele L Markwardt, Adam Zviman, Guoli Shi, Jaclyn P Kerr, Nicole E Snell, Jennifer J McFarland, Joseph R Mauban, Christopher W Ward, Megan A Rizzo, Jin Zhang
Publikováno v:
eLife, Vol 7 (2018)
Genetically encoded fluorescent biosensors have revolutionized the study of signal transduction by enabling the real-time tracking of signaling activities in live cells. Investigating the interaction between signaling networks has become increasingly
Externí odkaz:
https://doaj.org/article/daf2e8e4686046bbbaeec9259aa19b87
Autor:
Iryna Kishko, Balasubramanian Harish, Vasilina Zayats, David Reha, Brian Tenner, Dhananjay Beri, Tobias Gustavsson, Rüdiger Ettrich, Jannette Carey
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43902 (2012)
The E. coli protein WrbA is an FMN-dependent NAD(P)H:quinone oxidoreductase that has been implicated in oxidative defense. Three subunits of the tetrameric enzyme contribute to each of four identical, cavernous active sites that appear to accommodate
Externí odkaz:
https://doaj.org/article/b795f4ab548c4ee6a7e0d85388b29fd6
Autor:
Xin Chen, Jin Zhang, Christopher H. Bohrer, Jie Xiao, Matthew Wooten, Brian Tenner, Elijah Roberts, Brian Ross, Xiaoli Weng, Shreyasi Thakur, Xinxing Yang, Melike Lakadamyali, Ryan McQuillen
Publikováno v:
Nat Methods
Single-molecule localization microscopy (SMLM) relies on the blinking behavior of a fluorophore, which is the stochastic switching between fluorescent and dark states. Blinking creates multiple localizations belonging to the same fluorophore, confoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84eaf1e2c14e778519684b66c62cbc67
https://doi.org/10.1038/s41592-021-01154-y
https://doi.org/10.1038/s41592-021-01154-y
Autor:
Bian Liu, Jin‐Fan Zhang, Ingie Hong, Albert Mo, Richard Roth, Brian Tenner, Wei Lin, Jason Zhang, Rosana Molina, Mikhail Drobizhev, Thomas Hughes, Tian Lin, Richard Huganir, Sohum Mehta, Jin Zhang
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a547e0fb1226a2956802ba74c63acc8a
https://doi.org/10.1096/fasebj.2021.35.s1.05431
https://doi.org/10.1096/fasebj.2021.35.s1.05431
Autor:
Brian Tenner, Yonghoon Kwon, Siyu Feng, Jin Zhang, Jason Z. Zhang, Veronica Pessino, Bo Huang, Sohum Mehta
Publikováno v:
Science Advances
Fluorescent sensors targeted to endogenous proteins measure native signaling dynamics within signaling compartments.
Growing evidence suggests that many essential intracellular signaling events are compartmentalized within kinetically distinct m
Growing evidence suggests that many essential intracellular signaling events are compartmentalized within kinetically distinct m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5824799a2cca06c4a71c06f02c9ece1d
http://europepmc.org/articles/PMC8139597
http://europepmc.org/articles/PMC8139597
Author response: Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit
Autor:
Michael Getz, Jin Zhang, Jie Xiao, Donya Ohadi, Brian Tenner, Christopher H. Bohrer, Brian Ross, Padmini Rangamani, Sohum Mehta, Eric Greenwald
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bf3b0722203a9893bc62d2082d6aabe
https://doi.org/10.7554/elife.55013.sa2
https://doi.org/10.7554/elife.55013.sa2
Autor:
Mikhail Drobizhev, Brian Tenner, Bian Liu, Ingie Hong, Rosana S. Molina, Thomas E. Hughes, Lin Tian, Jin Fan Zhang, Albert Mo, Richard L. Huganir, Wei Lin, Jason Z. Zhang, Sohum Mehta, Richard H. Roth, Jin Zhang
Publikováno v:
Nat Chem Biol
Protein kinases control nearly every facet of cellular function. These key signaling nodes integrate diverse pathway inputs to regulate complex physiological processes, and aberrant kinase signaling is linked to numerous pathologies. While fluorescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36eee3647fc9c5624ca3124c16d86734
https://pubmed.ncbi.nlm.nih.gov/32989297
https://pubmed.ncbi.nlm.nih.gov/32989297