Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Brian T. Wipke"'
Autor:
Seymour de Picciotto, Nicholas DeVita, Chiaowen Joyce Hsiao, Christopher Honan, Sze-Wah Tse, Mychael Nguyen, Joseph D. Ferrari, Wei Zheng, Brian T. Wipke, Eric Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
IL-2 has been used to expand regulatory T (Treg) cells for treating inflammatory disorders. Here the authors test an engineered IL-2 mutein, delivered subcutaneously as mRNA, to show its increased specificity for activating and expanding Treg cells i
Externí odkaz:
https://doaj.org/article/970f3a986644427281a56650bf34012f
Autor:
Kerri Somebang, Joshua Rudolph, Isabella Imhof, Luyi Li, Erene C. Niemi, Judy Shigenaga, Huy Tran, T. Michael Gill, Iris Lo, Brian A. Zabel, Gabriela Schmajuk, Brian T. Wipke, Stefka Gyoneva, Luke Jandreski, Michael Craft, Gina Benedetto, Edward D. Plowey, Israel Charo, James Campbell, Chun Jimmie Ye, S. Scott Panter, Mary C. Nakamura, Walter Eckalbar, Christine L. Hsieh
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109727- (2021)
Summary: In traumatic brain injury (TBI), a diversity of brain resident and peripherally derived myeloid cells have the potential to worsen damage and/or to assist in healing. We define the heterogeneity of microglia and macrophage phenotypes during
Externí odkaz:
https://doaj.org/article/011455846f9d403785ab73e8519ead87
Autor:
Seymour de Picciotto, Nicholas DeVita, Chiaowen Joyce Hsiao, Christopher Honan, Sze-Wah Tse, Mychael Nguyen, Joseph D. Ferrari, Wei Zheng, Brian T. Wipke, Eric Huang
Publikováno v:
Nature communications. 13(1)
Interleukin-2 (IL-2) is critical for regulatory T cell (Treg) function and homeostasis. At low doses, IL-2 can suppress immune pathologies by expanding Tregs that constitutively express the high affinity IL-2Rα subunit. However, even low dose IL-2,
Autor:
Yaman Lu, Krista L. Namminga, Howard E. Gendelman, Brian T. Wipke, Katherine E. Olson, Eric Huang, Clayton Small, Sze-Wah Tse, Jared Iacovelli, William Walker, Seymour De Picciotto, R. Lee Mosley, Mackenzie J. Thurston, Aaron D. Schwab
Publikováno v:
Biomaterials
Restoring numbers and function of regulatory T cells (Tregs) is a novel therapeutic strategy for neurodegenerative disorders. Whether Treg function is boosted by adoptive cell transfer, pharmaceuticals, or immune modulators, the final result is a rob
Autor:
Gina Benedetto, Isabella Imhof, Brian T. Wipke, Mary C. Nakamura, Huy Tran, Luyi Li, Walter L. Eckalbar, Israel F. Charo, Chun Jimmie Ye, James Campbell, Michael Craft, Eréne C. Niemi, Christine L. Hsieh, Gabriela Schmajuk, Stefka Gyoneva, Kerri Somebang, Luke Jandreski, Iris Lo, Judy K. Shigenaga, T. Michael Gill, Brian A. Zabel, Joshua Rudolph, S. Scott Panter, Edward D. Plowey
Publikováno v:
Cell reports
Cell Reports, Vol 36, Iss 12, Pp 109727-(2021)
Cell reports, vol 36, iss 12
Cell Reports, Vol 36, Iss 12, Pp 109727-(2021)
Cell reports, vol 36, iss 12
SUMMARY In traumatic brain injury (TBI), a diversity of brain resident and peripherally derived myeloid cells have the potential to worsen damage and/or to assist in healing. We define the heterogeneity of microglia and macrophage phenotypes during T
Autor:
Suzanne Szak, Robert H. Scannevin, Ralf Gold, Robert Hoepner, Katrin Strassburger-Krogias, Maximilian Pistor, Melanie S. Brennan, Andrew T. Chan, Davide Gianni, Brian T. Wipke, Ankur M. Thomas
Publikováno v:
Wipke, Brian T; Hoepner, Robert; Strassburger-Krogias, Katrin; Thomas, Ankur M; Gianni, Davide; Szak, Suzanne; Brennan, Melanie S; Pistor, Maximilian; Gold, Ralf; Chan, Andrew; Scannevin, Robert H (2021). Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses. Neurology: Neuroimmunology and Neuroinflammation, 8(2) Wolters Kluwer Health 10.1212/NXI.0000000000000950
Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3
Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3
ObjectiveTo test the hypothesis that dimethyl fumarate (DMF, Tecfidera) elicits different biological changes from DMF combined with monoethyl fumarate (MEF) (Fumaderm, a psoriasis therapy), we investigated DMF and MEF in rodents and cynomolgus monkey
Autor:
Alex Pellerin, Brian Collette, Abhishek Datta, Jason D. Fontenot, Liaomin Peng, Brian T. Wipke, David J. Huss, Arun K. Kannan
Publikováno v:
Immunology. 148:276-286
Interleukin-2 (IL-2) is a critical regulator of immune homeostasis through its non-redundant role in regulatory T (Treg) cell biology. There is major interest in therapeutic modulation of the IL-2 pathway to promote immune activation in the context o
Autor:
Bin Wang, Marion Wittmann, Elena Morozova, Brian D. Harvey, Diego Cadavid, Brian T. Wipke, Brandon J. Farley, Jessica Dion, Davide Gianni, Mihály Hajós
Publikováno v:
Molecular and Cellular Neuroscience. 99:103393
Enhancing remyelination is a key therapeutic strategy for demyelinating diseases such as multiple sclerosis. To achieve this goal, a central challenge is being able to quantitatively and longitudinally track functional remyelination, especially with
Autor:
Raymond A. Sobel, Collin M. Spencer, Brian T. Wipke, Ulf Schulze-Topphoff, Bruce A.C. Cree, Michel Varrin-Doyer, Lawrence Steinman, Robert H. Scannevin, Scott S. Zamvil, Aparna Shetty, Sharon A. Sagan, Kara Pekarek
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 17
Dimethyl fumarate (DMF) (BG-12, Tecfidera) is a fumaric acid ester (FAE) that was advanced as a multiple sclerosis (MS) therapy largely for potential neuroprotection as it was recognized that FAEs are capable of activating the antioxidative transcrip
Autor:
Robert H. Scannevin, Silvia Rossi, Sara Morando, Benedetta Parodi, Antonio Uccelli, Brian T. Wipke, Caterina Motta, Nicole Kerlero de Rosbo, Giovanni Luigi Mancardi, Cesare Usai, Alberto Bragoni, Diego Centonze, Christian Cordano
Publikováno v:
Acta Neuropathologica
Acta neuropathologica 130 (2015): 279–295. doi:10.1007/s00401-015-1422-3
info:cnr-pdr/source/autori:Parodi B.; Rossi S.; Morando S.; Cordano C.; Bragoni A.; Motta C.; Usai C.; Wipke B.T.; Scannevin R.H.; Mancardi G.L.; Centonze D.; Kerlero de Rosbo N.; Uccelli A./titolo:Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS/doi:10.1007%2Fs00401-015-1422-3/rivista:Acta neuropathologica/anno:2015/pagina_da:279/pagina_a:295/intervallo_pagine:279–295/volume:130
Acta neuropathologica 130 (2015): 279–295. doi:10.1007/s00401-015-1422-3
info:cnr-pdr/source/autori:Parodi B.; Rossi S.; Morando S.; Cordano C.; Bragoni A.; Motta C.; Usai C.; Wipke B.T.; Scannevin R.H.; Mancardi G.L.; Centonze D.; Kerlero de Rosbo N.; Uccelli A./titolo:Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS/doi:10.1007%2Fs00401-015-1422-3/rivista:Acta neuropathologica/anno:2015/pagina_da:279/pagina_a:295/intervallo_pagine:279–295/volume:130
Dimethyl fumarate (DMF), recently approved as an oral immunomodulatory treatment for relapsing-remitting multiple sclerosis (MS), metabolizes to monomethyl fumarate (MMF) which crosses the blood–brain barrier and has demonstrated neuroprotective ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b7cd4f7fd444a5c9904fd90ef84858
http://hdl.handle.net/11567/809538
http://hdl.handle.net/11567/809538