Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Brian T. Layden"'
Autor:
Arron T. L. Correia, Philippa E. Forshaw, Laura C. Roden, Gosia Lipinska, H. G. Laurie Rauch, Estelle V. Lambert, Brian T. Layden, Sirimon Reutrakul, Stephanie J. Crowley, Amy Luke, Lara R. Dugas, Dale E. Rae
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract South Africans living in low socioeconomic areas have self-reported unusually long sleep durations (approximately 9–10 h). One hypothesis is that these long durations may be a compensatory response to poor sleep quality as a result of stre
Externí odkaz:
https://doaj.org/article/97c71ae3b4154fccbdf287c6045933ba
Autor:
Gertrude Ecklu-Mensah, Candice Choo-Kang, Maria Gjerstad Maseng, Sonya Donato, Pascal Bovet, Bharathi Viswanathan, Kweku Bedu-Addo, Jacob Plange-Rhule, Prince Oti Boateng, Terrence E. Forrester, Marie Williams, Estelle V. Lambert, Dale Rae, Nandipha Sinyanya, Amy Luke, Brian T. Layden, Stephen O’Keefe, Jack A. Gilbert, Lara R. Dugas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The relationship between microbiota, short chain fatty acids (SCFAs), and obesity remains enigmatic. We employ amplicon sequencing and targeted metabolomics in a large (n = 1904) African origin cohort from Ghana, South Africa, Jamaica, Seych
Externí odkaz:
https://doaj.org/article/9f2902999c364d3f91963cc158c00b6a
Autor:
Ayis Pyrros, Stephen M. Borstelmann, Ramana Mantravadi, Zachary Zaiman, Kaesha Thomas, Brandon Price, Eugene Greenstein, Nasir Siddiqui, Melinda Willis, Ihar Shulhan, John Hines-Shah, Jeanne M. Horowitz, Paul Nikolaidis, Matthew P. Lungren, Jorge Mario Rodríguez-Fernández, Judy Wawira Gichoya, Sanmi Koyejo, Adam E Flanders, Nishith Khandwala, Amit Gupta, John W. Garrett, Joseph Paul Cohen, Brian T. Layden, Perry J. Pickhardt, William Galanter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e2d1fcc1da9a4a75bc20a627cd3c3ba8
Autor:
Ayis Pyrros, Stephen M. Borstelmann, Ramana Mantravadi, Zachary Zaiman, Kaesha Thomas, Brandon Price, Eugene Greenstein, Nasir Siddiqui, Melinda Willis, Ihar Shulhan, John Hines-Shah, Jeanne M. Horowitz, Paul Nikolaidis, Matthew P. Lungren, Jorge Mario Rodríguez-Fernández, Judy Wawira Gichoya, Sanmi Koyejo, Adam E Flanders, Nishith Khandwala, Amit Gupta, John W. Garrett, Joseph Paul Cohen, Brian T. Layden, Perry J. Pickhardt, William Galanter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Deep learning (DL) models can harness electronic health records (EHRs) to predict diseases and extract radiologic findings for diagnosis. With ambulatory chest radiographs (CXRs) frequently ordered, we investigated detecting type 2 diabetes
Externí odkaz:
https://doaj.org/article/7a733957020f47618b736360b6cd8f9b
Autor:
Dhavamani Sugasini, Jason C. Park, J. Jason McAnany, Tae-Hoon Kim, Guangying Ma, Xincheng Yao, Babu Antharavally, Anil Oroskar, Asha A. Oroskar, Brian T. Layden, Papasani V. Subbaiah
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Alzheimer disease (AD) is the most prevalent cause of dementia in the elderly. Although impaired cognition and memory are the most prominent features of AD, abnormalities in visual functions often precede them, and are increasingly being use
Externí odkaz:
https://doaj.org/article/b0f8746686a34e1289bf3e014810371d
Autor:
Carolina M. Pusec, Vladimir Ilievski, Adam De Jesus, Zeenat Farooq, Joseph L. Zapater, Nadia Sweis, Hagar Ismail, Md Wasim Khan, Hossein Ardehali, Jose Cordoba-Chacon, Brian T. Layden
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract A primary role of the liver is to regulate whole body glucose homeostasis. Glucokinase (GCK) is the main hexokinase (HK) expressed in hepatocytes and functions to phosphorylate the glucose that enters via GLUT transporters to become glucose-
Externí odkaz:
https://doaj.org/article/071b50d72cdc40519a71ce57d0f855c6
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Cognitive function in humans depends on the complex and interplay between multiple body systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which vastly outnumbers human cells and has a genetic potential that exceeds
Externí odkaz:
https://doaj.org/article/6559bf4bd8de4ed0a9d337641d21e800
Autor:
Md. Wasim Khan, Alexander R. Terry, Medha Priyadarshini, Vladimir Ilievski, Zeenat Farooq, Grace Guzman, Jose Cordoba-Chacon, Issam Ben-Sahra, Barton Wicksteed, Brian T. Layden
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-17 (2022)
Mitochondrial interaction of HKDC1 is essential for its pro-proliferative role in LC. When HKDC1 is ablated in liver cancer cells, mitochondrial dysfunction occurs which results in decrease ATP in the cells. The cancer cells react to decreased cellul
Externí odkaz:
https://doaj.org/article/7091df137c6f4bf0aaa04fb1d39d604d
Autor:
Raghavendra G. Mirmira, Rohit N. Kulkarni, Pingwen Xu, Tina Drossos, Krista Varady, Kristen L. Knutson, Sirimon Reutrakul, Pamela Martyn-Nemeth, Robert M. Sargis, Amisha Wallia, Arleen M. Tuchman, Jill Weissberg-Benchell, Kirstie K. Danielson, Scott A. Oakes, Celeste C. Thomas, Brian T. Layden, Sarah C. May, Michelle Burbea Hoffmann, Eleonora Gatta, Julian Solway, Louis H. Philipson
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Stress and diabetes coexist in a vicious cycle. Different types of stress lead to diabetes, while diabetes itself is a major life stressor. This was the focus of the Chicago Biomedical Consortium’s 19th annual symposium, “Stress and Human Health:
Externí odkaz:
https://doaj.org/article/229e064d51b9496b995463d9593c8865
Autor:
Raza Ali Naqvi, Afsar Raza Naqvi, Amar Singh, Medha Priyadarshini, Appakalai N. Balamurugan, Brian T. Layden
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
Replacement of β cells is only a curative approach for type 1 diabetes (T1D) patients to avoid the threat of iatrogenic hypoglycemia. In this pursuit, islet allotransplantation under Edmonton’s protocol emerged as a medical miracle to attain hypog
Externí odkaz:
https://doaj.org/article/f987d924f3f24e58a87a52c072e8185e