A Neurofunctional Domains Approach to Evaluate D1/D5 Dopamine Receptor Partial Agonism on Cognition and Motivation in Healthy Volunteers With Low Working Memory Capacity

Autor: Gabriel H Braley, Rita Balice-Gordon, Zhiyong Xie, Melissa Naylor, Brian T. Harel, Wenlei Liu, Rouba Kozak, Lovingly Park, Estibaliz Arce, Garry D. Honey, David Gray, Sridhar Duvvuri, Christopher H. Chatham, Nicholas DeMartinis

Publikováno v: International Journal of Neuropsychopharmacology

BackgroundDopamine D1 receptor signaling plays key roles in core domains of neural function, including cognition and reward processing; however, many questions remain about the functions of circuits modulated by dopamine D1 receptor, largely because

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf55c7a013c49047909a42b3c0e5eb4c
http://europepmc.org/articles/PMC7251631

The development of associate learning in school age children.

Autor: Brian T Harel, Robert H Pietrzak, Peter J Snyder, Elizabeth Thomas, Linda C Mayes, Paul Maruff

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e101750 (2014)

Associate learning is fundamental to the acquisition of knowledge and plays a critical role in the everyday functioning of the developing child, though the developmental course is still unclear. This study investigated the development of visual assoc

Externí odkaz: https://doaj.org/article/25b211c5b22f4bb881deb9b402cd51ce

A novel approach to evaluate the pharmacodynamics of a selective dopamine D1/D5 receptor partial agonist (PF-06412562) in patients with stable schizophrenia

Autor: Estibaliz Arce, Sridhar Duvvuri, Nicholas DeMartinis, David Gray, Brian T. Harel, Zhiyong Xie, Rouba Kozak, Rita Balice-Gordon, Melissa Naylor

Publikováno v: Journal of psychopharmacology (Oxford, England). 33(10)

Background: PF-06412562 is an orally bioavailable, selective dopamine D1/D5 receptor partial agonist with a non-catechol structure under evaluation for treatment of cognitive impairment in schizophrenia. Aims: This randomized, double-blind, placebo-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f2c872ec7442f14ce94a9f84a24871
https://pubmed.ncbi.nlm.nih.gov/31264510

Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry

Autor: Shannon Finley, Diana Truran, David Bickford, Philip S. Insel, Derek Flenniken, R. Scott Mackin, Aaron Ulbright, Rachel L. Nosheny, Monica Comacho, Paul Maruff, Brian T. Harel, Michael W. Weiner

Publikováno v: Alzheimer's & dementia (Amsterdam, Netherlands), vol 10, iss 1
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 573-582 (2018)
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

IntroductionThe purpose of this study is to compare online neuropsychological test performance of older adults across self-reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer's disease and to deter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50c93a6957f8349b18032aca29c2bc8
https://escholarship.org/uc/item/4hn4m6k8

A Review of Childhood and Adolescent Craniopharyngiomas With Particular Attention to Hypothalamic Obesity

Autor: Jeffrey W. Miller, Michael Etzl, Micah L. Olson, Allen M. Kaplan, Brian T. Harel, Adrian Schembri, Daniel Arrington, Amy Rosenfeld, Annie Gieseking

Publikováno v: Pediatric Neurology. 50:4-10

BACKGROUND: Although craniopharyngiomas are considered “benign” neoplasms by the World Health Organization classification, these tumors may create significant morbidity and mortality in patients. Hypothalamic obesity is a frequent complication of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9964c50a859bdad74c7a17072cae1200
https://doi.org/10.1016/j.pediatrneurol.2013.09.003