Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Brian T. Farrer"'
Autor:
Bei Zhang, Jiayi Xu, Robert W. Myers, Roman Kats-Kagan, Qinghong Fu, Sunita Malkani, Hsuan-shen Chen, Rui Zhang, Maria E. Trujillo, Michael Kavana, Daniel R. McMasters, Brian T. Campbell, George H. Addona, George J. Eiermann, Zhesheng Chen, Michele Pachanski, Fengqi Zhang, Brian T. Farrer, Kaushik Mitra, Libo Xu, Nadine Elowe, Joel P. Berger, Emma R. Parmee, Songnian Lin, Wen Feng, Xinchun Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2069-2073
Glucokinase (GK, hexokinase IV) is a unique hexokinase that plays a central role in mammalian glucose homeostasis. Glucose phosphorylation by GK in the pancreatic β-cell is the rate-limiting step that controls glucose-stimulated insulin secretion. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f297c94aef86ac210547893541fab565
https://doi.org/10.1016/j.bmcl.2016.10.085
https://doi.org/10.1016/j.bmcl.2016.10.085
Autor:
Wen Feng, Bei Zhang, Songnian Lin, Sunita Malkani, Hsuan-shen Chen, Libo Xu, Jiayi Xu, Rui Zhang, Nadine Elowe, Qinghong Fu, Maria E. Trujillo, Zhesheng Chen, Brian T. Farrer, Robert W. Myers, Michele Pachanski, Michael Kavana, George H. Addona, Daniel R. McMasters, George J. Eiermann, Xinchun Tong, Roman Kats-Kagan, Joel P. Berger, Emma R. Parmee, Brian T. Campbell, Fengqi Zhang, Kaushik Mitra
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(9)
Systemically acting glucokinase activators (GKA) have been demonstrated in clinical trials to effectively lower blood glucose in patients with type II diabetes. However, mechanism-based hypoglycemia is a major adverse effect that limits the therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7740f05d44a9ebea4c672e3b5380708
https://pubmed.ncbi.nlm.nih.gov/28284809
https://pubmed.ncbi.nlm.nih.gov/28284809
Publikováno v:
Journal of Pharmaceutical Sciences. 99:4973-4981
(1S,5R)-2-{[(4S)-azepan-4-ylamino]carbonyl}-7-oxo-2,6-diazabicyclo[3.2.0] heptane-6-sulfonic acid (Compound 1) is a β-lactamase inhibitor for intravenous administration. The objective of this preformulation study was to determine the most appropriat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cddc19a077622781e6f518d88024974
https://doi.org/10.1002/jps.22225
https://doi.org/10.1002/jps.22225
Autor:
Brian T. Farrer, Tsu Chien Weng, Manolis Matzapetakis, Lars Hemmingsen, Vincent L. Pecoraro, James E. Penner-Hahn
Publikováno v:
Journal of the American Chemical Society. 124:8042-8054
Designed alpha-helical peptides of the TRI family with a general sequence Ac-G(LKALEEK)(4)G-CONH(2) were used as model systems for the study of metal-protein interactions. Variants containing cysteine residues in positions 12 (TRI L12C) and 16 (TRI L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3e62fe263ec584179f117a10ec754a
https://doi.org/10.1021/ja017520u
https://doi.org/10.1021/ja017520u
Publikováno v:
Biochemistry. 40:14696-14705
A thermodynamic model is presented that describes the binding of Hg(II) to de novo designed peptides, Tri L9C and Baby L9C, which were derived from the Tri family. The Tri peptides are based on the parent sequence Ac-NH-G(LKALEEK)(x)()G-CONH(2) and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dcadf9b7dc48ef63f795f6f8fd4c6c2
https://doi.org/10.1021/bi015649a
https://doi.org/10.1021/bi015649a
Publikováno v:
Journal of the American Chemical Society. 122:549-553
The effect of polar 2‘-substituents on the oxidation of nucleic acids at the 1‘-C−H bond was investigated. Oligonucleotides with the sequence 5‘-ATI CCC2‘-X TTI CIT AT-3‘ (I = inosine, −X = −H, −NH2, − OCH3, −F) were synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d49026fe98a5f8c0c0123b92c8476a38
https://doi.org/10.1021/ja991967+
https://doi.org/10.1021/ja991967+
Autor:
Brian T. Farrer, H. Holden Thorp
Publikováno v:
Inorganic Chemistry. 38:2497-2502
The kinetics of the comproportionation reaction of Ru(tpy)(bpy)O2+ and Ru(tpy)(bpy)OH22+ to produce Ru(tpy)(bpy)OH2+ were evaluated in a series of complexes that were substituted on the 4‘ position...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6efdfc98f29209796f0df6bc0786a6c
https://doi.org/10.1021/ic9902323
https://doi.org/10.1021/ic9902323
Publikováno v:
Journal of pharmaceutical sciences. 96(2)
A method to detect and quantify a small amount crystalline material within a liquid solution of solubilized material is described. 19 F CP-MAS ssNMR was investigated as a technique to detect low levels (0.2 mg /g) of crystalline sodium (2R)-7-{3-[2-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce30b71fdec0549cca20556fd4eed6e
https://pubmed.ncbi.nlm.nih.gov/17051585
https://pubmed.ncbi.nlm.nih.gov/17051585
Autor:
Brian T, Farrer, Vincent L, Pecoraro
Publikováno v:
Current opinion in drug discoverydevelopment. 5(6)
From poisoning caused by lead-based paint on domestic buildings to groundwater contamination by naturally occurring arsenic deposits in India, heavy-metal toxicity is a global health problem. Contaminated ground water and acute cases of heavy-metal p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4d9a40fed5d169926dbf7e134fd9c6f
https://pubmed.ncbi.nlm.nih.gov/12478724
https://pubmed.ncbi.nlm.nih.gov/12478724