Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Brian T Hopkins"'
Autor:
Eris Bame, Hao Tang, Jeremy C Burns, Million Arefayene, Klaus Michelsen, Bin Ma, Isaac Marx, Robin Prince, Allie M Roach, Urjana Poreci, Douglas Donaldson, Patrick Cullen, Fergal Casey, Jing Zhu, Thomas M Carlile, Dipen Sangurdekar, Baohong Zhang, Patrick Trapa, Joseph Santoro, Param Muragan, Alex Pellerin, Stephen Rubino, Davide Gianni, Bekim Bajrami, Xiaomei Peng, Alex Coppell, Katherine Riester, Shibeshih Belachew, Devangi Mehta, Mike Palte, Brian T Hopkins, Matthew Scaramozza, Nathalie Franchimont, Michael Mingueneau
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract Objectives Bruton's tyrosine kinase (BTK) plays a non‐redundant signaling role downstream of the B‐cell receptor (BCR) in B cells and the receptors for the Fc region of immunoglobulins (FcR) in myeloid cells. Here, we characterise BIIB09
Externí odkaz:
https://doaj.org/article/960649d0c0f948e3add268a6d5cc0401
Autor:
George H. Vandeveer, Robert M. Arduini, Darren P. Baker, Kevin Barry, Tonika Bohnert, Jon K. Bowden-Verhoek, Patrick Conlon, Patrick F. Cullen, Bing Guan, Tracy J. Jenkins, Shu-Yu Liao, Lin Lin, Yu-Ting Liu, Douglas Marcotte, Elisabeth Mertsching, Claire M. Metrick, Ella Negrou, Noel Powell, Daniel Scott, Laura F. Silvian, Brian T. Hopkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 80
For the past two decades, BTK a tyrosine kinase and member of the Tec family has been a drug target of significant interest due to its potential to selectively treat various B cell-mediated diseases such as CLL, MCL, RA, and MS. Owning to the challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d0ad0019514664a9cffc401198edd2
https://pubmed.ncbi.nlm.nih.gov/36538993
https://pubmed.ncbi.nlm.nih.gov/36538993
Autor:
Tricia L. May-Dracka, Fang Gao, Brian T. Hopkins, Xiaoping Hronowski, TeYu Chen, Jayanth V. Chodaparambil, Claire M. Metrick, Mike Cullivan, Istvan Enyedy, Maciej Kaliszczak, Mark W. Kankel, Isaac Marx, Mackenzie A. Michell-Robinson, Param Murugan, P. Rajesh Kumar, Michael Rooney, Eli Schuman, Anindya Sen, Ti Wang, Tao Ye, Emily A. Peterson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. From a therapeutic perspective, PLD has been implicated in human canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe055bd69fb8ef7e48f9498480b28a32
https://europepmc.org/articles/PMC9014516/
https://europepmc.org/articles/PMC9014516/
Autor:
Kevin L. Otipoby, Sarah Sheikh, Douglas Marcotte, George A. Moniz, Michael Humora, Brian T. Hopkins, Judy Bai, Karen Smirnakis, J. Michael Macphee, Tonika Bohnert, Timothy R. Chan, Devangi Mehta, Bin Ma, Million Arefayene, Zheng Fengmei, Lei Zhang, Patricia Schroeder, Annick Prefontaine, Eris Bame, Urjana Poreci, Evelyne Polack, Eric Tien, Claire M. Metrick, Bekim Bajrami
Publikováno v:
Journal of Medicinal Chemistry. 63:12526-12541
Autoreactive B cell-derived antibodies form immune complexes that likely play a pathogenic role in autoimmune diseases. In systemic lupus erythematosus (SLE), these antibodies bind Fc receptors on myeloid cells and induce proinflammatory cytokine pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7847a2561125cd5a06e20ac411c45701
https://doi.org/10.1021/acs.jmedchem.0c00702
https://doi.org/10.1021/acs.jmedchem.0c00702
Autor:
Chaomin Li, Yiqing Lin, John Guzowski, Lloyd Franklin, Brian T. Hopkins, Michael MacPhee, Daniel Patience, Bin Ma, Zheng Fengmei, Michael Humora, Robbie Chen, Erin M. O’Brien, George A. Moniz, William F. Kiesman, Steven Ferguson, Tamera Mack
Publikováno v:
Organic Process Research & Development. 24:1199-1206
Chemical process development efforts leading to multikilogram production of BIIB068 hemiadipate are discussed. Process optimization resulted in (1) removal of transition metal from the process, (2)...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7697bd2139a22f282f464a8ae16c611
https://doi.org/10.1021/acs.oprd.0c00087
https://doi.org/10.1021/acs.oprd.0c00087
Autor:
Rui Li, Hao Tang, Jeremy C. Burns, Brian T. Hopkins, Carole Le Coz, Bo Zhang, Isabella Peixoto de Barcelos, Neil Romberg, Amy C. Goldstein, Brenda L. Banwell, Eline T. Luning Prak, Michael Mingueneau, Amit Bar-Or
Publikováno v:
Acta neuropathologica. 143(4)
Inhibition of Bruton’s Tyrosine Kinase (BTKi) is now viewed as a promising next-generation B-cell-targeting therapy for autoimmune diseases including multiple sclerosis (MS). Surprisingly little is known; however, about how BTKi influences MS disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886814103a6a1741aa0acfc4070d4674
https://pubmed.ncbi.nlm.nih.gov/35379952
https://pubmed.ncbi.nlm.nih.gov/35379952
Autor:
Bin Ma, Urjana Poreci, Luisette Delva, Fengmei Zhang, Hao Tang, Tonika Bohnert, Patricia Schroeder, Richard Grater, Sudarshan Kapadnis, Kris King, Michael Mingueneau, Marc Hoemberger, Evelyne Polack, Brian T. Hopkins, Prince Robin, Chris Rowbottom, Robert Meissner, Eris Bame, Joseph C Santoro, Paramasivam Murugan, Allie M Roach, Claire M. Metrick, Kevin L. Otipoby, Eric Tien, Josh Johnson, Douglas Donaldson, Joseph P. Lyssikatos, Doug Burdette, Tom Magee, Carrie Boiselle, Chungang Gu, Mukesh Lulla, Bekim Bajrami, Jeremy C. Burns, Cheryl Black, Marx Isaac
Publikováno v:
Journal of medicinal chemistry. 65(2)
Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder of the central nervous system (CNS) that is characterized by inflammation, demyelination, and axonal injury leading to permeant disability. In the early stage of MS, inflammation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73da50c6f550d3e41002d416b5cebb6
https://pubmed.ncbi.nlm.nih.gov/34734694
https://pubmed.ncbi.nlm.nih.gov/34734694
Autor:
Bin Ma, Claire M. Metrick, Chungang Gu, Marc Hoemberger, Bekim Bajrami, Eris Bame, Jiansheng Huang, Michael Mingueneau, Paramasivam Murugan, Joseph C. Santoro, Hao Tang, Ti Wang, Brian T. Hopkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 60
BTK is a tyrosine kinase playing an important role in B cell and myeloid cell functions through B cell receptor (BCR) signaling and Fc receptor (FcR) signaling. Selective inhibition of BTK has the potential to provide therapeutical benefits to patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bd32b8fdba50b6f9d163e6c24a3190
https://pubmed.ncbi.nlm.nih.gov/35728998
https://pubmed.ncbi.nlm.nih.gov/35728998
Autor:
Bin Ma, Claire M. Metrick, Chungang Gu, Marc Hoemberger, Bekim Bajrami, Eris Bame, Jiansheng Huang, Michael Mingueneau, Paramasivam Murugan, Marta Nevalainen, Joseph C. Santoro, Hao Tang, Ti Wang, Brian T. Hopkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128856
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2269328ef74fb6f1cdf55f7c5dd90de
https://doi.org/10.1016/j.bmcl.2022.128856
https://doi.org/10.1016/j.bmcl.2022.128856
Autor:
Tonika Bohnert, Brian T. Hopkins, Stig Hansen, Laura Silvian, Patrick Cullen, Min Zhong, Stacey A. Heumann, Junfa Fan, Noah Bell, Elisabeth Mertsching, Tracy J. Jenkins, Ella Negrou, Eris Bame, Douglas Marcotte, Kevin L. Otipoby, Michael J. Romanowski, Bob McDowell, Wenjin Yang, Daniel A. Erlanson, Patrick Conlon, Mark T. Cancilla, Minna Bui, Urjana Poreci, Daniel Scott, Tarra Fuchs-Knotts, Jon K. Bowden-Verhoek
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2905-2913
Since the approval of ibrutinib for the treatment of B-cell malignancies in 2012, numerous clinical trials have been reported using covalent inhibitors to target Bruton's tyrosine kinase (BTK) for oncology indications. However, a formidable challenge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f47fdcd71f2c89e2f54cba793dfbcb
https://doi.org/10.1016/j.bmc.2019.05.021
https://doi.org/10.1016/j.bmc.2019.05.021