Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Brian T Emmer"'
Autor:
Vi T Tang, Joseph McCormick, Bolin Xu, Yawei Wang, Huan Fang, Xiao Wang, David Siemieniak, Rami Khoriaty, Brian T Emmer, Xiao-Wei Chen, David Ginsburg
Publikováno v:
eLife, Vol 11 (2022)
PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4 as a cargo receptor t
Externí odkaz:
https://doaj.org/article/a6d70a225b594945be13e85a8f5d5bed
Autor:
Emily J Sherman, Carmen Mirabelli, Vi T Tang, Taslima G Khan, Kyle Leix, Andrew A Kennedy, Sarah E Graham, Cristen J Willer, Andrew W Tai, Jonathan Z Sexton, Christiane E Wobus, Brian T Emmer
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010377 (2022)
SARS-CoV-2 infection is initiated by binding of the viral spike protein to its receptor, ACE2, on the surface of host cells. ACE2 expression is heterogeneous both in vivo and in immortalized cell lines, but the molecular pathways that govern ACE2 exp
Externí odkaz:
https://doaj.org/article/acccdef33b934d528edc14fc2c53eec4
Autor:
Brian T Emmer, Emily J Sherman, Paul J Lascuna, Sarah E Graham, Cristen J Willer, David Ginsburg
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009285 (2021)
Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease. A critical pathway regulating cholesterol homeostasis involves the receptor-mediated endocytosis of low-density lipoproteins into hepatocytes, med
Externí odkaz:
https://doaj.org/article/b69d1bece3cb4a27a991ea55effe4e85
Autor:
Brian T Emmer, Paul J Lascuna, Vi T Tang, Emilee N Kotnik, Thomas L Saunders, Rami Khoriaty, David Ginsburg
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227450 (2020)
Newly synthesized proteins co-translationally inserted into the endoplasmic reticulum (ER) lumen may be recruited into anterograde transport vesicles by their association with specific cargo receptors. We recently identified a role for the cargo rece
Externí odkaz:
https://doaj.org/article/727d58a836d841bb96970c37a76b1129
Autor:
Brian T Emmer, Geoffrey G Hesketh, Emilee Kotnik, Vi T Tang, Paul J Lascuna, Jie Xiang, Anne-Claude Gingras, Xiao-Wei Chen, David Ginsburg
Publikováno v:
eLife, Vol 7 (2018)
PCSK9 is a secreted protein that regulates plasma cholesterol levels and cardiovascular disease risk. Prior studies suggested the presence of an ER cargo receptor that recruits PCSK9 into the secretory pathway, but its identity has remained elusive.
Externí odkaz:
https://doaj.org/article/4d0ae922f1f64db9a2cd6c2f5d6ed374
Autor:
Emily J. Sherman, Brian T. Emmer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The membrane protein angiotensin-converting enzyme 2 (ACE2) is a physiologic regulator of the renin-angiotensin system and the cellular receptor for the SARS-CoV-2 virus. Prior studies of ACE2 expression have primarily focused on mRNA abunda
Externí odkaz:
https://doaj.org/article/7145808995e74ee79c0e061525cf7b93
Autor:
Qianyi Ma, Paula M. Jacobi, Brian T. Emmer, Colin A. Kretz, Ayse Bilge Ozel, Beth McGee, Chava Kimchi-Sarfaty, David Ginsburg, Jun Z. Li, Karl C. Desch
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1037-1046 (2017)
Abstract: The metalloprotease ADAMTS13 cleaves von Willebrand factor (VWF) in circulating blood, limiting the size of VWF multimers and regulating VWF activity. Abnormal regulation of VWF contributes to bleeding and to thrombotic disorders. ADAMTS13
Externí odkaz:
https://doaj.org/article/34d445472d274fd4b9422c0423282360
Autor:
Juliana Bragazzi Cunha, Kyle Leix, Emily J. Sherman, Carmen Mirabelli, Andrew A. Kennedy, Adam S. Lauring, Andrew W. Tai, Christiane E. Wobus, Brian T. Emmer
Disease progression during SARS-CoV-2 infection is tightly linked to the fate of lung epithelial cells, with severe cases of COVID-19 characterized by direct injury of the alveolar epithelium and an impairment in its regeneration from progenitor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d9bc51020fb224f2bd7b3a68f43a6c0
https://doi.org/10.1101/2023.02.28.530557
https://doi.org/10.1101/2023.02.28.530557
Autor:
Conrad L. Epting, Brian T. Emmer, Nga Y. Du, Joann M. Taylor, Ming Y. Makanji, Cheryl L. Olson, David M. Engman
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT African trypanosomiasis is caused by infection with the protozoan parasite Trypanosoma brucei. During infection, this pathogen divides rapidly to high density in the bloodstream of its mammalian host in a manner similar to that of leukemia.
Externí odkaz:
https://doaj.org/article/31d7a561c496421a96c0f83003ea87a1
Autor:
Vi T Tang, Joseph McCormick, Bolin Xu, Yawei Wang, Huan Fang, Xiao Wang, David Siemieniak, Rami Khoriaty, Brian T Emmer, Xiao-Wei Chen, David Ginsburg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3503f89a118f5c2b1197f9a8510dc8c3
https://doi.org/10.7554/elife.82269.sa2
https://doi.org/10.7554/elife.82269.sa2