Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Brian T D, Tobe"'
Autor:
Wen-Ning Zhao, Brian T. D. Tobe, Namrata D. Udeshi, Lucius L. Xuan, Cameron D. Pernia, Daniel P. Zolg, Amanda J. Roberts, Deepak Mani, Sarah R. Blumenthal, Iren Kurtser, Debasis Patnaik, Irina Gaisina, Joshua Bishop, Steven D. Sheridan, Jasmin Lalonde, Steven A. Carr, Evan Y. Snyder, Stephen J. Haggarty
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract The effective treatment of bipolar disorder (BD) represents a significant unmet medical need. Although lithium remains a mainstay of treatment for BD, limited knowledge regarding how it modulates affective behavior has proven an obstacle to
Externí odkaz:
https://doaj.org/article/3adcd41d1c9642cb98771f72e34b370f
Autor:
Evan Y. Snyder, Angela R. Ozburn, Colleen A. McClung, Mariah A. Hildebrand, George C. Tseng, Jeffrey Oliver-Smith, Matthew B Jarpe, Alicia M. Winquist, Hui Zhang, Wei Zong, Puja K. Parekh, Darius Becker-Krail, Zhiguang Huo, Ethan Fitzgerald, Rachel N. Arey, Xiyu Zhu, Lauren M. DePoy, Andrew Crain, Kyle D. Ketchesin, Brian T. D. Tobe, Xiangning Xue, Ryan W. Logan
Publikováno v:
Molecular psychiatry
Valproate (VPA) has been used in the treatment of bipolar disorder since the 1990s. However, the therapeutic targets of VPA have remained elusive. Here we employ a preclinical model to identify the therapeutic targets of VPA. We find compounds that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3c998801c8fc52a7971dd952089690
http://europepmc.org/articles/PMC8141541
http://europepmc.org/articles/PMC8141541
Autor:
Joseph T. Coyle, Richard L. Sidman, Brian T. D. Tobe, Aoi Jitsuki-Takahashi, Hiroko Makihara, Fumio Nakamura, Haruko Nakamura, Yoshio Hirayasu, Keisuke Watanabe, Naoya Yamashita, Glenn T. Konopaske, Evan Y. Snyder, Cameron D Pernia, Yoshio Goshima, Munetaka Nomoto, Reina Aoki, Yusuke Saigusa, Toshihiko Baba, Francine M. Benes, Mari Saito
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance There are no biomarkers for schizophrenia (SCZ), a disorder of dysfunctional neural networks. We demonstrate that a master regulator of cytoskeleton (“CRMP2”) and, hence, neural circuitry, may form the basis for such a biomarker beca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a9bb79a052ee84bd9c78fb40d942ed
http://europepmc.org/articles/PMC8346854
http://europepmc.org/articles/PMC8346854
Autor:
Deepak Mani, Cameron D. Pernia, Steven D. Sheridan, Jasmin Lalonde, Joshua A. Bishop, Brian T. D. Tobe, Debasis Patnaik, Namrata D. Udeshi, Stephen J. Haggarty, Steven A. Carr, Lucius L Xuan, Irina N. Gaisina, Evan Y. Snyder, Sarah R. Blumenthal, Daniel P Zolg, Wen-Ning Zhao, Amanda J. Roberts, Iren Kurtser
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-18 (2020)
Translational Psychiatry
Translational Psychiatry
The effective treatment of bipolar disorder (BD) represents a significant unmet medical need. Although lithium remains a mainstay of treatment for BD, limited knowledge regarding how it modulates affective behavior has proven an obstacle to discoveri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d09891b9b55d8c4fe273563331e97d
https://doi.org/10.1038/s41398-020-0753-6
https://doi.org/10.1038/s41398-020-0753-6
Autor:
Stephen J. Haggarty, Brian T. D. Tobe, Yoshio Goshima, Cameron D. Pernia, Evan Y. Snyder, Neal H. Nathan, Richard L. Sidman
Throughout much of human and medical history the brain has been a black box opaque to scientific investigation for a myriad of reasons ranging from societal to logistical barriers. Compounding this opacity, the biological effects of ecologically sour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92c4a24ffc6d2a90fffe7b9b7f544f05
https://doi.org/10.1016/b978-0-12-812034-7.00017-0
https://doi.org/10.1016/b978-0-12-812034-7.00017-0
Autor:
Brian T. D. Tobe, Alicia M. Winquist, Laurence M. Brill, Gustavo J. Gutierrez, Andrew Crain, Stuart A. Lipton, Junjie Hou, Jennifer Choy, Kutbuddin S. Doctor, Maria Talantova, Evan Y. Snyder, Esther La Monaca, Dieter A. Wolf, Xiayu Huang, David Horn, Ilyas Singec
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 7, Iss 3, Pp 527-542 (2016)
Stem cell reports, vol 7, iss 3
Stem Cell Reports, Vol 7, Iss 3, Pp 527-542 (2016)
Stem cell reports, vol 7, iss 3
Summary Controlled differentiation of human embryonic stem cells (hESCs) can be utilized for precise analysis of cell type identities during early development. We established a highly efficient neural induction strategy and an improved analytical pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f648220803f9d96faf220f4af68fd67c
http://europepmc.org/articles/PMC5032292
http://europepmc.org/articles/PMC5032292
Autor:
Cameron D, Pernia, Neal H, Nathan, Brian T D, Tobe, Alicia M, Winquist, Richard L, Sidman, Yoshio, Goshima, Evan Y, Snyder
Publikováno v:
Results and problems in cell differentiation. 66
The pathogenesis of bipolar disorder (BPD) is unknown. Using human-induced pluripotent stem cells (hiPSCs) to unravel pathological mechanisms in polygenic diseases is challenging, with few successful studies to date. However, hiPSCs from BPD patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca4f33033e708328d55b2188ef5e237e
https://pubmed.ncbi.nlm.nih.gov/30209664
https://pubmed.ncbi.nlm.nih.gov/30209664
Autor:
Brian T. D. Tobe, Alicia M. Winquist, Neal H. Nathan, Cameron D. Pernia, Evan Y. Snyder, Richard L. Sidman, Yoshio Goshima
Publikováno v:
Results and Problems in Cell Differentiation ISBN: 9783319934846
The pathogenesis of bipolar disorder (BPD) is unknown. Using human-induced pluripotent stem cells (hiPSCs) to unravel pathological mechanisms in polygenic diseases is challenging, with few successful studies to date. However, hiPSCs from BPD patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e366b3627a449da00d24a5ab9a0c22e7
https://doi.org/10.1007/978-3-319-93485-3_12
https://doi.org/10.1007/978-3-319-93485-3_12
Autor:
Fumio Nakamura, Husseini K. Manji, Namrata D. Udeshi, Hagop S. Akiskal, Jeffrey H. Price, Nikolaos Venizelos, Wen-Ning Zhao, Cordulla Duerr, Ryan W. Logan, Jeffrey S. Nye, Jasmin Lalonde, Steven D. Sheridan, Joseph T. Coyle, Toshio Ohshima, Yoshio Goshima, Michael McCarthy, Shelley Halpain, Barbara Calabrese, Joshua G. Hunsberger, Martin Alda, Yuuka Inoue, Gustavo J. Gutierrez, Stephen J. Haggarty, Brian T. D. Tobe, Cameron D. Pernia, Richard L. Sidman, Moyuka Wada, Hiroko Makihara, Laurence M. Brill, Glenn T. Konopaske, Yang Liu, De-Maw M. Chuang, Ranor C. B. Basa, Alicia M. Winquist, Yang D. Teng, Michelle M. Sidor, Steven A. Carr, Colleen A. McClung, Guy A. Rouleau, Katsuhiko Mikoshiba, Evan Y. Snyder, Laurel Dorsett, Lina Mastrangelo, Guang Chen, Jianxue Li, Haruko Nakamura, Andrew Crain, Philipp Mertins, Michael G. Brandel, Dongmei Wu, Naoya Yamashita
Publikováno v:
Publikationer från Örebro universitet.
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af943d65b2b76fb0f4b555e7351a2c67
http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-57888
http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-57888
Autor:
Alicia M. Winquist, Jin Woo Lee, Evan Y. Snyder, Ilyas Singec, Shaochen Chen, Pranav Soman, Kenneth S. Vecchio, Brian T. D. Tobe
Publikováno v:
Biomedical Microdevices. 14:829-838
Access to unlimited numbers of live human neurons derived from stem cells offers unique opportunities for in vitro modeling of neural development, disease-related cellular phenotypes, and drug testing and discovery. However, to develop informative ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d3558c33ee6a83908820108aa7b48f
https://doi.org/10.1007/s10544-012-9662-7
https://doi.org/10.1007/s10544-012-9662-7