Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Brian Storrie"'
Autor:
Sagar S. Matharu, Cassidy S. Nordmann, Kurtis R. Ottman, Rahul Akkem, Douglas Palumbo, Denzel R. D. Cruz, Kenneth Campbell, Gail Sievert, Jamie Sturgill, James Z. Porterfield, Smita Joshi, Hammodah R. Alfar, Chi Peng, Irina D. Pokrovskaya, Jeffrey A. Kamykowski, Jeremy P. Wood, Beth Garvy, Maria A. Aronova, Sidney W. Whiteheart, Richard D. Leapman, Brian Storrie
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
AbstractPlatelets contribute to COVID-19 clinical manifestations, of which microclotting in the pulmonary vasculature has been a prominent symptom. To investigate the potential diagnostic contributions of overall platelet morphology and their α-gran
Externí odkaz:
https://doaj.org/article/568668bf99a4473e9c0e48d15d0ffc3d
Autor:
Milena Dimori, Irina D. Pokrovskaya, Shijie Liu, John T. Sherrill, Horacio Gomez-Acevedo, Qiang Fu, Brian Storrie, Vladimir V. Lupashin, Roy Morello
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Smith McCort (SMC) dysplasia is a rare, autosomal recessive, osteochondrodysplasia that can be caused by pathogenic variants in either RAB33B or DYM genes. These genes codes for proteins that are located at the Golgi apparatus and have a role in intr
Externí odkaz:
https://doaj.org/article/d94a2c4c6eae415fa7aff58c2e50c49b
Autor:
Sung W. Rhee, Irina D. Pokrovskaya, Kelly K. Ball, Kenny Ling, Yajnesh Vedanaparti, Joshua Cohen, Denzel R. D. Cruz, Oliver S. Zhao, Maria A. Aronova, Guofeng Zhang, Jeffrey A. Kamykowski, Richard D. Leapman, Brian Storrie
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Rhee, Pokrovskaya et al. utilize 3D electron microscopy of mouse jugular vein puncture wounds to reveal thrombi structured around localized, nucleated platelet aggregates that produced a vaulted thrombus capped by extravascular platelet adherence. As
Externí odkaz:
https://doaj.org/article/576b9d87891e479cb420267b55d5590f
Autor:
Irina Pokrovskaya, Michael Tobin, Rohan Desai, Maria A. Aronova, Jeffrey A. Kamykowski, Guofeng Zhang, Smita Joshi, Sidney W. Whiteheart, Richard D. Leapman, Brian Storrie
Publikováno v:
Platelets, Vol 32, Iss 5, Pp 608-617 (2021)
Mice and mouse platelets are major experimental models for hemostasis and thrombosis; however, important physiological data from this model has received little to no quantitative, 3D ultrastructural analysis. We used state-of-the-art, serial block im
Externí odkaz:
https://doaj.org/article/5302f5be21d74dcea59923f8eb663d65
Autor:
Irina D. Pokrovskaya, Michael Tobin, Rohan Desai, Smita Joshi, Jeffrey A. Kamykowski, Guofeng Zhang, Maria A. Aronova, Sidney W. Whiteheart, Richard D. Leapman, Brian Storrie
Publikováno v:
Platelets, Vol 32, Iss 1, Pp 97-104 (2021)
The canalicular system (CS) has been defined as: 1) an inward, invaginated membrane connector that supports entry into and exit from the platelet; 2) a static structure stable during platelet isolation; and 3) the major source of plasma membrane (PM)
Externí odkaz:
https://doaj.org/article/ac206aa68a0840e4befb528bf6f5fa0a
Autor:
Matthew D. Guay, Zeyad A. S. Emam, Adam B. Anderson, Maria A. Aronova, Irina D. Pokrovskaya, Brian Storrie, Richard D. Leapman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Biologists who use electron microscopy (EM) images to build nanoscale 3D models of whole cells and their organelles have historically been limited to small numbers of cells and cellular features due to constraints in imaging and analysis. Th
Externí odkaz:
https://doaj.org/article/41216f2c37bc4441ab20307a221baaf2
Autor:
Irina D. Pokrovskaya, Shilpi Yadav, Amith Rao, Emma McBride, Jeffrey A. Kamykowski, Guofeng Zhang, Maria A. Aronova, Richard D. Leapman, Brian Storrie
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 1, Pp 72-85 (2020)
Abstract Background State‐of‐the‐art 3‐dimensional (3D) electron microscopy approaches provide a new standard for the visualization of human platelet ultrastructure. Application of these approaches to platelets rapidly fixed prior to purifica
Externí odkaz:
https://doaj.org/article/9e2820b32b544c35b0587580e299144e
Autor:
Dawid Krokowski, Bo-Jhih Guan, Jing Wu, Yuke Zheng, Padmanabhan P. Pattabiraman, Raul Jobava, Xing-Huang Gao, Xiao-Jing Di, Martin D. Snider, Ting-Wei Mu, Shijie Liu, Brian Storrie, Eric Pearlman, Anna Blumental-Perry, Maria Hatzoglou
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2895-2910 (2017)
Summary: GADD34, a stress-induced regulatory subunit of the phosphatase PP1, is known to function in hyperosmotic stress through its well-known role in the integrated stress response (ISR) pathway. Adaptation to hyperosmotic stress is important for t
Externí odkaz:
https://doaj.org/article/d251b901866045d39c6dbea94d5add74
Autor:
Shilpi Yadav, Jonathan K. Williamson, Maria A. Aronova, Andrew A. Prince, Irina D. Pokrovskaya, Richard D. Leapman, Brian Storrie
Publikováno v:
Platelets, Vol 28, Iss 4, Pp 400-408 (2017)
Platelets are small, anucleate cell fragments that are central to hemostasis, thrombosis, and inflammation. They are derived from megakaryocytes from which they inherit their organelles. As platelets can synthesize proteins and contain many of the en
Externí odkaz:
https://doaj.org/article/03c2ea18fd6043d69dcbaafa16e0eab3
Autor:
Shilpi Yadav, Brian Storrie
Publikováno v:
Platelets, Vol 28, Iss 2, Pp 108-118 (2017)
Platelet activation has long been known to be accompanied by secretion from at least three types of compartments. These include dense granules, the major source of small molecules; α-granules, the major protein storage organelle; and lysosomes, the
Externí odkaz:
https://doaj.org/article/72b891a721ff4d6c885f9b44ab876e9d