Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Brian Scharf"'
Autor:
Chiara Melis, Esperanza Arias, Victor Chatterjee, Kateryna Morozova, Jason E. Gestwicki, Erik R. P. Zuiderweg, Susmita Kaushik, Atta Ahmad, Brian Scharf, Ana Maria Cuervo, Jennifer N. Rauch, Barbara Stiller, Cristina C. Clement, Laura Santambrogio
Publikováno v:
The Journal of biological chemistry, vol 291, iss 35
hsc-70 (HSPA8) is a cytosolic molecular chaperone, which plays a central role in cellular proteostasis, including quality control during protein refolding and regulation of protein degradation. hsc-70 is pivotal to the process of macroautophagy, chap
Autor:
Sanjay Khandelwal, Laura Santambrogio, Paul A. Roche, Erica L. Heipertz, Brian Scharf, Adam C. Berger, Berta Bosch
Publikováno v:
Journal of Biological Chemistry. 288:24286-24292
The antigen processing compartments in antigen-presenting cells (APCs) have well known characteristics of multivesicular bodies (MVBs). However, the importance of MVB integrity to APC function remains unknown. In this study, we have altered the ultra
Autor:
Brian Scharf, Giovanna M. Crisi, Daniel Paget, Sriram Chitta, Laura Santambrogio, Radhashree Maitra, Cristina C. Clement, P. Edward Purdue, Neil J. Cobelli
Publikováno v:
Molecular Immunology. 47:175-184
Ultra-high molecular weight polyethylene is widely used as a bearing surface in prosthetic arthroplasty. Over time the generation of implant-derived wear particles can initiate an inflammatory reaction characterized by periprosthetic inflammation and
Autor:
Louis D. Trombetta, Brian Scharf
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 71:1300-1306
This study examined the toxicity and accumulation of copper in the livers and kidneys of Long-Evans rats after a subacute exposure to copper dimethyldithiocarbamate (CDCC) wood preservative. CDDC was recently introduced as an alternative to chromated
Autor:
Laura Santambrogio, Cristina C. Clement, Sunandini Sridhar, Katherine A. Hajjar, Ana Maria Cuervo, Kateryna Morozova, Zoe Verzani, Valerio Zolla, Jorge N. Larocca, Brian Scharf, Antonio Diaz
Publikováno v:
Nature Communications. 6
Corrigendum: Annexin A2 promotes phagophore assembly by enhancing Atg16 + vesicle biogenesis and homotypic fusion
Annexin A2 promotes phagophore assembly by enhancing Atg16L+ vesicle biogenesis and homotypic fusion
Autor:
Jorge N. Larocca, Antonio Diaz, Zoe Verzani, Kateryna Morozova, Sunandini Sidhar, Brian Scharf, Valerio Zolla, Ana Maria Cuervo, Cristina C. Clement, Laura Santambrogio, Katherine A. Hajjar
Publikováno v:
Nature Communications
Plasma membrane budding of Atg-16L-positive vesicles represents a very early event in the generation of the phagophore and in the process of macroautophagy. Here we show that the membrane curvature-inducing protein annexin A2 contributes to the forma
Autor:
Anatoliy A. Gashev, John S. Condeelis, Jean-Christophe Leroux, Cristina C. Clement, William R. Jacobs, Daisuke Maejima, Sangeeta Tiwari, Irina Tsoy Nizamutdinova, Takashi Nagai, David C. Zawieja, Paola Luciani, Tony J. Akl, Sabriya Stukes, Valerio Zolla, Cornelia Halin, David Entenberg, Laura Santambrogio, David R. Fooksman, Arturo Casadevall, Brian Scharf
Publikováno v:
Aging Cell
Aging Cell, 14 (4)
Aging Cell, 14 (4)
The role of lymphatic vessels is to transport fluid, soluble molecules, and immune cells to the draining lymph nodes. Here, we analyze how the aging process affects the functionality of the lymphatic collectors and the dynamics of lymph flow. Ultrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d061a0ce49b20f59b9543bf76bb17b02
Autor:
Frank P. Macaluso, Valerio Zolla, Bo Yan, Neil J. Cobelli, Brian Scharf, Giorgio Perino, Steven R. Goldring, Cristina C. Clement, Laura Santambrogio, E. Purdue, S. Gokhan Elci, Richard W. Vachet
Publikováno v:
Scientific Reports
Occupational and environmental exposure to Co and Cr has been previously linked to a wide array of inflammatory and degenerative conditions and cancer. Recently, significant health concerns have been raised by the high levels of Cr and Co ions and co
Autor:
Neil J. Cobelli, John A. Hardin, Aleksandra M. Urbanska, David Aphkhazava, Brian Scharf, Cristina C. Clement, Sylvia O. Suadicani, Supansa Yodmuang, Mia M. Thi, Gordana Vunjak-Novakovic, Laura Santambrogio, Giorgio Perino
SummaryAging-related oxidative stress has been linked to degenerative modifications in different organs and tissues. Using redox proteomic analysis and illustrative tandem mass spectrometry mapping, we demonstrate oxidative posttranslational modifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda78875663ac47d05ddfd93b01ff80e
https://europepmc.org/articles/PMC3758909/
https://europepmc.org/articles/PMC3758909/
Publikováno v:
Nature reviews. Rheumatology. 7(10)
Joint replacement surgery is one of the success stories of modern medicine, restoring mobility, diminishing pain and improving the overall quality of life for millions of people. Unfortunately, wear of these prostheses over time generates debris, whi