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Signal transduction pathways that contribute to increased protein synthesis during T-cell activation

Autor: Brian Safer, Scot R. Kimball, Suzanne Miyamoto

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1494:28-42

Protein synthesis rates were maximally stimulated in human lymphocytes by ionomycin and the phorbol ester PMA (I+P), which promotes proliferation, whereas PMA alone, which does not promote proliferation, stimulated protein synthesis to a lesser degre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188482ec4e621f18b8a9138b66e706a9
https://doi.org/10.1016/s0167-4781(00)00208-6

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Manometric changes during retrograde biliary infusion in mice

Autor: Myrna Mandel, Robert J. Lutz, Jennie W. Owens, Brian Safer, Randall R. Clevenger, John R. Deleonardis, Kunio Nagashima, Stephen M. Wiener, Michael Eckhaus, Robert F. Hoyt, Kenneth R. Jeffries

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 279:G49-G66

The manometric, ultrastructural, radiographic, and physiological consequences of retrograde biliary infusion were determined in normostatic and cholestatic mice. Intraluminal biliary pressure changed as a function of infusion volume, rate, and viscos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b06156b014454689663897904f5893
https://doi.org/10.1152/ajpgi.2000.279.1.g49

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Genomic Cloning and Characterization of the Human Eukaryotic Initiation Factor-2β Promoter

Autor: Suzanne Miyamoto, Brian Safer, John A. Chiorini, Stephanie J. Harkin

Publikováno v: Journal of Biological Chemistry. 274:4195-4201

The translation initiation factor eIF2 consists of three subunits that are present in equal molar amounts. The genomic DNA containing the gene for eIF2beta and its promoter were cloned and sequenced to characterize further the mechanism of their regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4946cfdca756e6966bae3da9d227ffd
https://doi.org/10.1074/jbc.274.7.4195

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Regulation of gene expression for translation initiation factor eIF-2α: importance of the 3′ untranslated region

Autor: John A. Chiorini, Suzanne Miyamoto, Elena Urcelay, Brian Safer

Publikováno v: Europe PubMed Central

Gene expression of the alpha-subunit of eukaryotic initiation factor-2 (eIF-2 alpha), involves transcriptional and post-transcriptional mechanisms. eIF-2 alpha is a single-copy gene expressing two mRNAs, 1.6 and 4.2 kb in size. Cloning and sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02b98fda7606439805206702873aa70
https://doi.org/10.1042/bj3150791

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Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats

Autor: S. R. M. Kyostio, Brian Safer, Roland A. Owens, S. M. Wiener, Robert M. Kotin, John A. Chiorini

Publikováno v: Journal of Virology. 68:7448-7457

Replication of the palindromic inverted terminal repeats (ITRs) of adeno-associated virus type 2 requires several functions of the viral nonstructural Rep proteins. These include binding to the ITR, nicking of the double-stranded replication intermed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0305588d71a4f3a6645c14f2c9690b
https://doi.org/10.1128/jvi.68.11.7448-7457.1994

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Characterization of an antisense Inr element in the eIF-2 alpha gene

Autor: Masayuki Noguchi, Brian Safer, Suzanne Miyamoto, Toby A. Silverman

Publikováno v: Journal of Biological Chemistry. 269:29161-29167

We recently discovered an opposing initiator promoter (Inr) downstream of the sense promoter region of the eIF-2 alpha gene (Silverman, T., Noguchi, M., and Safer, B. (1992) J. Biol. Chem. 267, 9738-9742). By reverse transcriptase/polymerase chain re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7693cd3365f752456b4e77e26af643
https://doi.org/10.1016/s0021-9258(19)62025-9

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The regulatory element 3' to the A gamma-globin gene binds to the nuclear matrix and interacts with special A-T-rich binding protein 1 (SATB1), an SAR/MAR-associating region DNA binding protein

Autor: Arthur W. Nienhuis, Elio F. Vanin, Paul A. Ney, Stephen M. Jane, Brian Safer, CH Lowrey, Mary Purucker, John M. Cunningham

Publikováno v: Blood. 84:1298-1308

A cis-acting DNA regulatory element 3′ to the A gamma-globin gene contains eight distinct regions of DNA-protein interaction distributed over 750 bp of DNA. The sequences of two foot-printed regions (sites I and IV) are A-T rich and generate a high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3760c98b0853eb464b57deac18289e8
https://doi.org/10.1182/blood.v84.4.1298.1298

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A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development

Autor: John A. Chiorini, Bassey J.S. Efiok, Brian Safer

Publikováno v: Journal of Biological Chemistry. 269:18921-18930

In response to growth, metabolic, and other signals, eukaryotic cells regulate protein biosynthesis through post-translational mechanisms which target the alpha subunit of eukaryotic initiation factor-2 (eIF-2 alpha). Previous efforts to study transc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5120a2494410adf066d63c181ad48a93
https://doi.org/10.1016/s0021-9258(17)32255-x

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