Differences in Circulating Extracellular Vesicle and Soluble Cytokines in Older Versus Younger Breast Cancer Patients With Distinct Symptom Profiles

Autor: Dilorom Sass, Wendy Fitzgerald, Brian S. Wolff, Isaias Torres, Glorivee Pagan-Mercado, Terri S. Armstrong, Christine Miaskowski, Leonid Margolis, Leorey Saligan, Kord M. Kober

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Because extracellular vesicle (EV)-associated cytokines, both encapsulated and surface bound, have been associated with symptom severity, and may vary over the lifespan, they may be potential biomarkers to uncover underlying mechanisms of various con

Externí odkaz: https://doaj.org/article/0b49c32da57b484ba10a528800cddfc6

Inflammation plays a causal role in fatigue-like behavior induced by pelvic irradiation in mice

Autor: Brian S. Wolff, Sarah A. Alshawi, Li Rebekah Feng, Paul L. Juneau, Leorey N. Saligan

Publikováno v: Brain, Behavior, & Immunity - Health, Vol 15, Iss , Pp 100264- (2021)

Fatigue is a persistent and debilitating symptom following radiation therapy for prostate cancer. However, it is not well-understood how radiation targeted to a small region of the body can lead to broad changes in behavior. In this study, we used ta

Externí odkaz: https://doaj.org/article/819af7d51df246e7b52597bcdf5ae4f0

Induction of fatigue-like behavior by pelvic irradiation of male mice alters cognitive behaviors and BDNF expression

Autor: Li Rebekah Feng, Brian S. Wolff, Sarah Alshawi, Sumiyya Raheem, Jeniece Regan, Leorey N. Saligan

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0235566 (2020)

Fatigue and cognitive deficits are often co-occurring symptoms reported by patients after radiation therapy for prostate cancer. In this study, we induced fatigue-like behavior in mice using targeted pelvic irradiation to mimic the clinical treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acb4c79072b750e7e6bd6e1b636e9be
http://europepmc.org/articles/PMC7332074

mGluR5 mediates post-radiotherapy fatigue development in cancer patients

Autor: Enrique J. deAndrés-Galiana, Brian S. Wolff, Leorey N. Saligan, Kristien J. M. Zaal, Li Rebekah Feng, Juan Luis Fernández-Martínez

Publikováno v: Translational Psychiatry, Vol 8, Iss 1, Pp 1-11 (2018)
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Translational Psychiatry

Cancer-related fatigue (CRF) is a common burden in cancer patients and little is known about its underlying mechanism. The primary aim of this study was to identify gene signatures predictive of post-radiotherapy fatigue in prostate cancer patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f980ed80cc57751181a9ee3414f3cce9
http://link.springer.com/article/10.1038/s41398-018-0161-3

4323 Inflammation partially mediates fatigue-like behavior in mice

Autor: Sarah Alshawi, Leorey N. Saligan, Brian S. Wolff

Publikováno v: Journal of Clinical and Translational Science. 4:8-9

OBJECTIVES/GOALS: Fatigue is a distressing side effect of cancer and its treatment. It is a subjective symptom that can include mental, physical, emotional, and motivational components. We sought to determine whether preventing inflammation affects f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b97c67a0c3d4812caadd886f0844d8e
https://doi.org/10.1017/cts.2020.71