Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Brian S. Meldrum"'
Publikováno v:
Epilepsy & Behavior. 71:165-173
This review summarizes the current knowledge about DBA/2 mice and genetically epilepsy-prone rats (GEPRs) and discusses the contribution of such animal models on the investigation of possible new therapeutic targets and new anticonvulsant compounds f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd8560c6f1952205acddf40c4471090
https://doi.org/10.1016/j.yebeh.2015.06.030
https://doi.org/10.1016/j.yebeh.2015.06.030
Publikováno v:
Journal of Neurochemistry. 62:1458-1467
The effect of the non-N-methyl-D-aspartate (non-NMDA) receptor antagonist 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride (GYKI 52466) on ischaemia-induced changes in the microdialysate and tissue concentrations of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b307fca7d9efdbbe9071f126ace1133e
https://doi.org/10.1046/j.1471-4159.1994.62041458.x
https://doi.org/10.1046/j.1471-4159.1994.62041458.x
Autor:
Michael A. Rogawski, Brian S. Meldrum
Publikováno v:
Neurotherapeutics. 4:18-61
This review considers how recent advances in the physiology of ion channels and other potential molecular targets, in conjunction with new information on the genetics of idiopathic epilepsies, can be applied to the search for improved antiepileptic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7243122d83cba75bc2407aead99411
https://doi.org/10.1016/j.nurt.2006.11.010
https://doi.org/10.1016/j.nurt.2006.11.010
Publikováno v:
European Journal of Pharmacology. 476:3-16
Metabotropic glutamate (mGlu) receptors have multiple actions on neuronal excitability through G-protein-linked modifications of enzymes and ion channels. They act presynaptically to modify glutamatergic and gamma-aminobutyric acid (GABA)-ergic trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1292ba1973fdc45afef83cd9749694e
https://doi.org/10.1016/s0014-2999(03)02149-6
https://doi.org/10.1016/s0014-2999(03)02149-6
Autor:
Vasso Episkopou, Benjamin J. Whalley, Antigoni Ekonomou, Heather Wood, Brian S. Meldrum, S Malas, Andrew Constanti, S Nishiguchi, M. Postlethwaite
Publikováno v:
Neuroscience. 119:421-432
Mutations in several classes of embryonically-expressed transcription factor genes are associated with behavioral disorders and epilepsies. However, there is little known about how such genetic and neurodevelopmental defects lead to brain dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45695cbe67e12671555e89a5893ce17b
https://doi.org/10.1016/s0306-4522(03)00158-1
https://doi.org/10.1016/s0306-4522(03)00158-1
Autor:
Nicoletta V Baloyianni, Michael S. Perkinton, Brian S. Meldrum, Marcus Rattray, Robert J. Williams, Sachin K. Suchak
Publikováno v:
Journal of Neurochemistry. 84:522-532
The excitatory amino acid transporters (EAAT) removes neurotransmitters glutamate and aspartate from the synaptic cleft. Most CNS glutamate uptake is mediated by EAAT2 into glia, though nerve terminals show evidence for uptake, through an unknown tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ae024a6b81cfde7831bed339ba6c0e1
https://doi.org/10.1046/j.1471-4159.2003.01553.x
https://doi.org/10.1046/j.1471-4159.2003.01553.x
Autor:
Brian S. Meldrum, Pierre Lestage, Hashim Al-Badri, Anita Roger, Astrid G. Chapman, Alex Cordi, Elisabeth Ruano, Claude Fugier, Patrice Desos, Jean-Yves Thomas
Publikováno v:
Il Farmaco. 57:787-802
We reported previously the synthesis and structure-activity relationships (SAR) in a series of 2-(1H)-oxoquinolines bearing different acidic functions in the 3-position. Exploiting these SAR, we were able to identify 6,7-dichloro-2-(1H)-oxoquinoline-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b001408976ceab4cd3d26243af071547
https://doi.org/10.1016/s0014-827x(02)01281-8
https://doi.org/10.1016/s0014-827x(02)01281-8
Autor:
Brian S. Meldrum
Publikováno v:
Epilepsy Research. 50:33-40
Classical screening tests (maximal electroshock, MES, and threshold pentylenetetrazol, PTZ) employ non-epileptic rodents and identify antiepileptic drugs (AEDs) with mechanisms of action associated with significant CNS side effects. Thus MES identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a218e614fb35e92112ab0bc672a7bac2
https://doi.org/10.1016/s0920-1211(02)00066-9
https://doi.org/10.1016/s0920-1211(02)00066-9
Publikováno v:
Journal of Neurochemistry. 78:13-23
The selective group-III metabotropic glutamate receptor agonist, L-serine-O-phosphate (L-SOP), when injected bilaterally into the inferior colliculus of the sound sensitive genetically epilepsy-prone (GEP) rats produces a short proconvulsant excitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4662a43525486493d9091e410fa5fec5
https://doi.org/10.1046/j.1471-4159.2001.00418.x
https://doi.org/10.1046/j.1471-4159.2001.00418.x
Autor:
Maria Jeffrey, Brian S. Meldrum, Philip M Beart, Ali Talebi, Astrid G. Chapman, Randal X. Moldrich
Publikováno v:
Neuropharmacology. 41:8-18
The selective group II metabotropic glutamate receptor (mGlu(2/3)) agonists (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (-)-2-thia-4-aminobicyclo[3.1.0]hexane-4 (LY389795) have been evaluated as anti-epileptic drugs in dilu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6cc0c3d52771097b09bfdc35606458
https://doi.org/10.1016/s0028-3908(01)00044-2
https://doi.org/10.1016/s0028-3908(01)00044-2