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pro vyhledávání: '"Brian S. Koss"'
Publikováno v:
Cancer Research. 82:6131-6131
The introduction of immunotherapy has drastically improved outcomes in cancer therapy, particularly in melanoma, the deadliest form of skin cancer. However, around half of melanoma tumors are initially resistant to treatment and a significant proport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2d28b3a627c72e2f3980f9196d93d1e
https://doi.org/10.1158/1538-7445.am2022-6131
https://doi.org/10.1158/1538-7445.am2022-6131
Publikováno v:
Cancer Research. 81:1577-1577
Immune checkpoint inhibitors (ICIs) have revolutionized melanoma therapy. Still, the 5-year survival for advanced melanoma is only 50%. This leads to two questions: what makes some tumors less responsive to ICIs, and what can be done to increase resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::092dbc736a180be8fc0e21ff2432fdcf
https://doi.org/10.1158/1538-7445.am2021-1577
https://doi.org/10.1158/1538-7445.am2021-1577
Autor:
L. Joseph Su, Stephanie D. Byrum, Tung-Chin Chiang, Charity Washam, Alan J. Koss, Aaron J. Storey, Brian Koss
Publikováno v:
Cancer Research. 80:B26-B26
UV exposure-induced oxidative stress is implicated as the driving mechanism of melanoma development. Increased oxidative stress results in imbalanced reactive oxygen species (ROS) that damage DNA and dysregulated epigenetic modifications and leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812518858f6432d3fd54505df25d13ee
https://doi.org/10.1158/1538-7445.mel2019-b26
https://doi.org/10.1158/1538-7445.mel2019-b26