Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Brian S. J. Blagg"'
Autor:
David I. Duron, Parthasaradhireddy Tanguturi, Christopher S. Campbell, Kerry Chou, Paul Bejarano, Katherin A. Gabriel, Jessica L. Bowden, Sanket Mishra, Christopher Brackett, Deborah Barlow, Karen L. Houseknecht, Brian S. J. Blagg, John M. Streicher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Opioids are the gold standard for the treatment of chronic pain but are limited by adverse side effects. In our earlier work, we showed that Heat shock protein 90 (Hsp90) has a crucial role in regulating opioid signaling in spinal cord; Hsp9
Externí odkaz:
https://doaj.org/article/224dd647f0154ca4bb4c8f2811b73164
Autor:
Amanda G. Smith, Valentin M. Kliebe, Sanket Mishra, Ryan P. McCall, Megan M. Irvine, Brian S. J. Blagg, Wei Lei
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Heat shock protein 90 (Hsp90) is a family of chaperone proteins that consists of four isoforms: Hsp90α, Hsp90β, glucose-regulated protein 94 (Grp94), and tumor necrosis factor type 1 receptor-associated protein (TRAP1). They are involved in modulat
Externí odkaz:
https://doaj.org/article/086fa855d2da4cde8523b71a382fcb37
Autor:
Ranu Pal, Dongwei Hui, Heather Menchen, Huiping Zhao, Olivier Mozziconacci, Heather Wilkins, Brian S. J. Blagg, Christian Schöneich, Russell H. Swerdlow, Mary L. Michaelis, Elias K. Michaelis
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
A feature of most neurodegenerative diseases is the presence of “mis-folded proteins” that form aggregates, suggesting suboptimal activity of neuronal molecular chaperones. Heat shock protein 90 (Hsp90) is the master regulator of cell responses t
Externí odkaz:
https://doaj.org/article/5aeb2462e3fd4a9d87dd8dfe62c1225c
Autor:
Brian S. J. Blagg
Publikováno v:
Current Topics in Medicinal Chemistry. 9:1335-1336
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Response resistance to the immune checkpoint blockade (ICB) immunotherapy remains a major clinical challenge that may be overcome through the rational combination of ICB and specific targeted therapeutics. One emerging combination strategy is based o
Externí odkaz:
https://doaj.org/article/6beeabc616a9462799decbd31aa4768c
Autor:
Chitra Subramanian, Patrick T. Grogan, Ton Wang, Joseph Bazzill, Ang Zuo, Peter T. White, Avinaash Kalidindi, Dawn Kuszynski, Grace Wang, Brian S. J. Blagg, Mark S. Cohen
Publikováno v:
Molecular Oncology, Vol 14, Iss 9, Pp 2058-2068 (2020)
In patients with triple‐negative breast cancer (TNBC), evidence suggests that tumor‐initiating cells (TIC) have stem cell‐like properties, leading to invasion and metastasis. HSP90 plays a critical role in the conformational maintenance of many
Externí odkaz:
https://doaj.org/article/b903ea765283488cbf81ea52f406e330
Autor:
Margaret J. Hilton, Christopher M. Brackett, Brandon Q. Mercado, Brian S. J. Blagg, Scott J. Miller
Publikováno v:
ACS Central Science, Vol 6, Iss 3, Pp 426-435 (2020)
Externí odkaz:
https://doaj.org/article/986b843fd1014d7e9f8d040931a52f63
Autor:
Bradley M. Keegan, Brian S. J. Blagg
Publikováno v:
ACS Chemical Biology. 18:184-192
Autor:
Sanket J. Mishra, Tyelor S. Reynolds, Taylor Merfeld, Maurie Balch, Shuxia Peng, Junpeng Deng, Robert Matts, Brian S. J. Blagg
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1870-1878
The heat shock protein 90 (Hsp90) family of molecular chaperones mediates the folding and activation of client proteins associated with all 10 hallmarks of cancer. Herein, the design, synthesis, and biological validation of Hsp90α-selective inhibito
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Opioid activation of the mu opioid receptor (MOR) promotes signaling cascades that evoke both analgesic responses to pain and side effects like addiction and dependence. Manipulation of these cascades, such as by biased agonism, has great promise to
Externí odkaz:
https://doaj.org/article/9fc67b842b574c10b83d599bf299a5bc