Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Brian S. Finlin"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Lipoprotein lipase (LPL) hydrolyzes the triglyceride core of lipoproteins and also functions as a bridge, allowing for lipoprotein and cholesterol uptake. Transgenic mice expressing LPL in adipose tissue under the control of the adiponectin
Externí odkaz:
https://doaj.org/article/7319c772f3da445b8eaa53bc8251b45b
Macrophages expressing uncoupling protein 1 increase in adipose tissue in response to cold in humans
Autor:
Brian S. Finlin, Hasiyet Memetimin, Amy L. Confides, Beibei Zhu, Philip M. Westgate, Esther E. Dupont-Versteegden, Philip A. Kern
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Acute cold induces beige adipocyte protein marker expression in human subcutaneous white adipose tissue (SC WAT) from both the cold treated and contralateral leg, and the immune system regulates SC WAT beiging in mice. Cold treatment signifi
Externí odkaz:
https://doaj.org/article/6c5044d732df4d2eb6330566329c9ef6
Autor:
Brian S. Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L. Confides, Hemendra J. Vekaria, Riham H. El Khouli, Zachary R. Johnson, Philip M. Westgate, Jianzhong Chen, Andrew J. Morris, Patrick G. Sullivan, Esther E. Dupont-Versteegden, Philip A. Kern
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
BACKGROUND Beige and brown adipose tissue (BAT) are associated with improved metabolic homeostasis. We recently reported that the β3-adrenergic receptor agonist mirabegron induced beige adipose tissue in obese insulin-resistant subjects, and this wa
Externí odkaz:
https://doaj.org/article/4492e0bd5623473ca8f914b2b47f39c5
Autor:
Brian S. Finlin, Beibei Zhu, Bernard P. Kok, Cristina Godio, Philip M. Westgate, Neile Grayson, Robert Sims, Jeffrey S. Bland, Enrique Saez, Philip A. Kern
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
ObjectiveIn a phase II clinical trial in nine obese, insulin-resistant humans, we observed that treatment with KDT501, a novel isohumulone drug, increased total and high-molecular weight (HMW) adiponectin in plasma. The objective was to determine whe
Externí odkaz:
https://doaj.org/article/5761a5a060794efcac5c040af2039d0f
Autor:
Devi Thiagarajan, Nosirudeen Quadri, Shabnam Jawahar, Hylde Zirpoli, Carmen Hurtado del Pozo, Raquel López‐Díez, Syed Nurul Hasan, Gautham Yepuri, Paul F. Gugger, Brian S. Finlin, Philip A. Kern, Kenneth Gabbay, Ann Marie Schmidt, Ravichandran Ramasamy
Publikováno v:
Obesity. 30:1647-1658
Aldose reductase (AKR1B1 in humans; Akr1b3 in mice), a key enzyme of the polyol pathway, mediates lipid accumulation in the murine heart and liver. The study objective was to explore potential roles for AKR1B1/Akr1b3 in the pathogenesis of obesity an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904d5d3d26df57e3d54d4f48cbddddd3
https://doi.org/10.1002/oby.23496
https://doi.org/10.1002/oby.23496
Autor:
Amy L. Confides, Esther E. Dupont-Versteegden, Hemendra J. Vekaria, Brian S. Finlin, Philip A. Kern, Patrick G. Sullivan, Hasiyet Memetimin, Jianzhong Chen, Riham H. El Khouli, Philip M. Westgate, Andrew J. Morris, Beibei Zhu, Zachary R. Johnson
Publikováno v:
Journal of Diabetes Investigation
BACKGROUNDBeige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470fffb28d6e3f3c3f80bb7613232b39
https://doi.org/10.1172/jci134892
https://doi.org/10.1172/jci134892
Autor:
Tania Boyechko, Josephine M. Egan, Brian S. Finlin, Philip M. Westgate, Chee W. Chia, Beibei Zhu, Philip A. Kern
Publikováno v:
Journal of the Endocrine Society
Context The gut microbiome is a source of inflammatory factors such as lipopolysaccharide (LPS; endotoxin) that influence metabolic homeostasis. Rifaximin is a well-tolerated antibiotic that may reduce LPS. Objective We sought to develop a method to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef23949bf2e81d9632478d9343b92a52
https://doi.org/10.1210/js.2019-00148
https://doi.org/10.1210/js.2019-00148
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:570-576
Sphingosine kinases phosphorylate sphingosine to sphingosine 1-phosphate (S1P), which functions as a signaling molecule. We have previously shown that sphingosine kinase 2 (Sphk2) is important for insulin secretion. To obtain a better understanding o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12afa4a7b57e04a1e20e18e830928e4c
https://doi.org/10.1016/j.bbadis.2018.12.012
https://doi.org/10.1016/j.bbadis.2018.12.012
Autor:
Kate Kosmac, R. Grace Walton, Beibei Zhu, Brian S. Finlin, Philip A. Kern, Jyothi Mula, Jason S. Groshong, Bailey D. Peck, Charlotte A. Peterson, Christopher S. Fry
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Skeletal muscle macrophages participate in repair and regeneration following injury. However, their role in physiological adaptations to exercise is unexplored. We determined whether endurance exercise training (EET) alters macrophage content and cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04237855fd76982046c1125b34d1c1ca
http://link.springer.com/article/10.1038/s41598-018-37187-1
http://link.springer.com/article/10.1038/s41598-018-37187-1
Autor:
Michael Spencer, Lin Yang, Akosua Adu, Brian S Finlin, Beibei Zhu, Lindsey R Shipp, Neda Rasouli, Charlotte A Peterson, Philip A Kern
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102190 (2014)
Adipose tissue in insulin resistant subjects contains inflammatory cells and extracellular matrix components. This study examined adipose pathology of insulin resistant subjects who were treated with pioglitazone or fish oil.Adipose biopsies were exa
Externí odkaz:
https://doaj.org/article/35a5df92e6c44ed1ac28761a0292dc91