Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Brian S. Comer"'
Autor:
Andrew P. Ferretti, Majed Matar, Jeff Sparks, Sabrina Ramelli, William T. Gerthoffer, Lydia L. Sandy, Jason G. Fewell, Jared M. McLendon, Brian S. Comer, Robert A. Barrington
Publikováno v:
Molecular Therapy. Nucleic Acids
To address the problem of poor asthma control due to drug resistance, an antisense oligonucleotide complementary to mmu-miR-145a-5p (antimiR-145) was tested in a house dust mite mouse model of mild/moderate asthma. miR-145 was targeted to reduce infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3feb1be03da00edc400312f91605d346
http://europepmc.org/articles/PMC7013130
http://europepmc.org/articles/PMC7013130
Autor:
Brian S. Comer, April W. Armstrong, Orin Goldblum, William N Malatestinic, Shonda A. Foster, Russel Burge, Chen-Yen Lin
Publikováno v:
BMC Dermatology, Vol 18, Iss 1, Pp 1-10 (2018)
BMC Dermatology
BMC Dermatology
Background Little is known regarding real-world health outcomes data among US psoriasis patients, but electronic health records (EHR) that collect structured data at point-of-care may provide opportunities to investigate real-world health outcomes am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdd2d1494de3311e719c484c69a3fbd
http://link.springer.com/article/10.1186/s12895-018-0072-2
http://link.springer.com/article/10.1186/s12895-018-0072-2
Autor:
Julian Solway, Andrew J. Halayko, Blanca Camoretti-Mercado, Brian S. Comer, Paul Kogut, William T. Gerthoffer
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 52:438-447
Cyclooxygenase-2 (COX-2) expression and PGE2 secretion from human airway smooth muscle cells (hASMCs) may contribute to β2-adrenoceptor hyporesponsiveness, a clinical feature observed in some patients with asthma. hASMCs from patients with asthma ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84844865ecc0a0b86dd2763fbe87542
https://doi.org/10.1165/rcmb.2014-0129oc
https://doi.org/10.1165/rcmb.2014-0129oc
Autor:
Brian S. Comer
Publikováno v:
Drug Development Research. 76:354-356
Preclinical Research MicroRNA (miR)-155 and cyclooxygenase (COX)-2 are both elevated in numerous cancers including colorectal cancer. MiR-155 enhances COX-2 expression and is an established regulator of epithelial-mesenchymal transition and inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e71e00d8ad05c8b36cf3b30527d2325e
https://doi.org/10.1002/ddr.21276
https://doi.org/10.1002/ddr.21276
Autor:
John P. Adelman, Mark S. Taylor, Mary I. Townsley, Mike T Lin, Brian S. Comer, Fui Chi Yap, David S. Weber, James Maylie
Activation of vascular endothelial small- (KCa2.3, SK3) or intermediate- (KCa3.1, IK1) conductance Ca2+-activated potassium channels induces vasorelaxation via an endothelium-derived hyperpolarization (EDH) pathway. Although the activation of SK3 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409e59a327528677335385e81118f707
https://europepmc.org/articles/PMC4867388/
https://europepmc.org/articles/PMC4867388/
Publikováno v:
Pulmonary Circulation
During normal lung development and in lung diseases structural cells in the lungs adapt to permit changes in lung function. Fibroblasts, myofibroblasts, smooth muscle, epithelial cells, and various progenitor cells can all undergo phenotypic modulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a5e5f8bb0877d41ac66f746ccf0c9f
https://doi.org/10.4103/2045-8932.87301
https://doi.org/10.4103/2045-8932.87301
Autor:
Brian S, Comer
Publikováno v:
Drug development research. 76(7)
Preclinical Research MicroRNA (miR)-155 and cyclooxygenase (COX)-2 are both elevated in numerous cancers including colorectal cancer. MiR-155 enhances COX-2 expression and is an established regulator of epithelial-mesenchymal transition and inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fb433bf1df142b2f8c31cef3943007f
https://pubmed.ncbi.nlm.nih.gov/26303353
https://pubmed.ncbi.nlm.nih.gov/26303353
Publikováno v:
Pharmacologytherapeutics. 147
In spite of substantial advances in defining the immunobiology and function of structural cells in lung diseases there is still insufficient knowledge to develop fundamentally new classes of drugs to treat many lung diseases. For example, there is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d5c4c53dff30e6e433f87b7da8ce5b
https://pubmed.ncbi.nlm.nih.gov/25448041
https://pubmed.ncbi.nlm.nih.gov/25448041
Autor:
Julian Solway, Andrew J. Halayko, William T. Gerthoffer, Blanca Camoretti-Mercado, Brian S. Comer
Publikováno v:
C71. MAJOR IMPACT OF MICRO-RNA FUNCTION.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c37537101e3e87eff2490ccfacaa18fc
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4992
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4992
Publikováno v:
B69. NOVEL INSIGHTS INTO AIRWAY INFLAMMATION AND REMODELING IN ASTHMA AND COPD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd8dd5ec5cfd578b79295d744d61c48
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3630
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3630