Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Brian S Mantilla"'
Autor:
Brian S. Mantilla, Jack S. White, William R. T. Mosedale, Andrew Gomm, Adam Nelson, Terry K. Smith, Megan H. Wright
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Sets of electrophilic probes are generally prepared using a narrow toolkit of robust reactions, which tends to limit both their structural and functional diversity. A unified synthesis of skeletally-diverse sulfonyl fluorides was developed t
Externí odkaz:
https://doaj.org/article/6ec208982da44492ac48af9d71880026
Autor:
Brian S Mantilla, Letícia Marchese, Aitor Casas-Sánchez, Naomi A Dyer, Nicholas Ejeh, Marc Biran, Frédéric Bringaud, Michael J Lehane, Alvaro Acosta-Serrano, Ariel M Silber
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006158 (2017)
Adaptation to different nutritional environments is essential for life cycle completion by all Trypanosoma brucei sub-species. In the tsetse fly vector, L-proline is among the most abundant amino acids and is mainly used by the fly for lactation and
Externí odkaz:
https://doaj.org/article/b3c6cd45955e4fbeb69fe74e831ff464
Autor:
Núria W. Negrão, Logan P. Crowe, Brian S. Mantilla, Rodrigo P. Baptista, Sharon King-Keller, Guozhong Huang, Roberto Docampo
Publikováno v:
Pathogens, Vol 12, Iss 3, p 386 (2023)
Trypanosoma brucei is the causative agent of African trypanosomiasis, a deadly disease that affects humans and cattle. There are very few drugs to treat it, and there is evidence of mounting resistance, raising the need for new drug development. Here
Externí odkaz:
https://doaj.org/article/13c4227fd6514268b0f34a0eebb76833
Autor:
Dorothea Fiedler, Brian S. Mantilla, Nathaniel W. Brown, Karunakaran A. Kalesh, Roberto Docampo
Publikováno v:
Molecular Microbiology. 115:986-1004
Diphosphoinositol-5-pentakisphosphate (5-PP-IP5 ), also known as inositol heptakisphosphate (5-IP7 ), has been described as a high-energy phosphate metabolite that participates in the regulation of multiple cellular processes through protein binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::485159bdb3b583b9f4cdfb0bf1c59a95
https://doi.org/10.1111/mmi.14672
https://doi.org/10.1111/mmi.14672
Publikováno v:
ACS Chemical Biology. 16:283-292
Inositol phosphates (IPs) are phosphorylated derivatives of myo-inositol involved in the regulation of several cellular processes through their interaction with specific proteins. Their synthesis relies on the activity of specific kinases that use AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bafad55d7ad47685fa27f644e6589b5
https://doi.org/10.1021/acschembio.0c00759
https://doi.org/10.1021/acschembio.0c00759
Autor:
Karunakaran Kalesh, Wenbin Wei, Brian S. Mantilla, Theodoros I. Roumeliotis, Jyoti Choudhary, Paul W. Denny
Publikováno v:
Microbiology Spectrum, 2022, Vol.10(1), pp.e02422-21 [Peer Reviewed Journal]
Proteomic profiling of RNA-binding proteins in Leishmania is currently limited to polyadenylated mRNA-binding proteins, leaving proteins that interact with nonadenylated RNAs, including noncoding RNAs and pre-mRNAs, unidentified. Using a combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c0bfb107f349ac33641007f9d9a523
http://dro.dur.ac.uk/36375/
http://dro.dur.ac.uk/36375/
Publikováno v:
mBio
mBio, Vol 12, Iss 6 (2021)
mBio, 2021, Vol.12(6) [Peer Reviewed Journal]
mBio, Vol 12, Iss 6 (2021)
mBio, 2021, Vol.12(6) [Peer Reviewed Journal]
Trypanosoma cruzi, the agent of Chagas disease, accumulates polyphosphate (polyP) and Ca2+ inside acidocalcisomes. The alkalinization of this organelle stimulates polyP hydrolysis and Ca2+ release. Here, we report that histidine ammonia lyase (HAL),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb293ffc20daa68de10ecc25f44d9462
http://europepmc.org/articles/PMC8561398
http://europepmc.org/articles/PMC8561398
Autor:
Simone Guedes Calderano, Ariel Mariano Silber, Felipe A. Dias, Lisvane Paes-Vieira, Pedro L. Oliveira, Brian S. Mantilla, José Roberto Meyer-Fernandes, Daniela Cosentino-Gomes, Maria Carolina Elias
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
The pathogenic protist Trypanosoma cruzi uses kissing bugs as invertebrate hosts that vectorize the infection among mammals. This parasite oxidizes proline to glutamate through two enzymatic steps and one nonenzymatic step. In insect vectors, T. cruz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9bb7e6cc613fa73d0434e6492478f2
https://pubmed.ncbi.nlm.nih.gov/34661234
https://pubmed.ncbi.nlm.nih.gov/34661234
Publikováno v:
ACS chemical biology. 16(2)
Inositol phosphates (IPs) are phosphorylated derivatives of myo-inositol involved in the regulation of several cellular processes through their interaction with specific proteins. Their synthesis relies on the activity of specific kinases that use AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::999b65b1c3fec99807d74f64375ef2a9
https://pubmed.ncbi.nlm.nih.gov/33411501
https://pubmed.ncbi.nlm.nih.gov/33411501
Autor:
Brian S, Mantilla, Karunakaran, Kalesh, Nathaniel W, Brown, Dorothea, Fiedler, Roberto, Docampo
Publikováno v:
Molecular microbiologyREFERENCES. 115(5)
Diphosphoinositol-5-pentakisphosphate (5-PP-IP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53c3bf5b0efa7f5793297cfa071b9d1b
https://pubmed.ncbi.nlm.nih.gov/33354791
https://pubmed.ncbi.nlm.nih.gov/33354791